475 research outputs found
Structural phase transitions in epitaxial perovskite films
Three different film systems have been systematically investigated to
understand the effects of strain and substrate constraint on the phase
transitions of perovskite films. In SrTiO films, the phase transition
temperature T was determined by monitoring the superlattice peaks
associated with rotations of TiO octahedra. It is found that T depends
on both SrTiO film thickness and SrRuO buffer layer thickness. However,
lattice parameter measurements showed no sign of the phase transitions,
indicating that the tetragonality of the SrTiO unit cells was no longer a
good order parameter. This signals a change in the nature of this phase
transition, the internal degree of freedom is decoupled from the external
degree of freedom. The phase transitions occur even without lattice relaxation
through domain formation. In NdNiO thin films, it is found that the
in-plane lattice parameters were clamped by the substrate, while out-of-plane
lattice constant varied to accommodate the volume change across the phase
transition. This shows that substrate constraint is an important parameter for
epitaxial film systems, and is responsible for the suppression of external
structural change in SrTiO and NdNiO films. However, in SrRuO films
we observed domain formation at elevated temperature through x-ray reciprocal
space mapping. This indicated that internal strain energy within films also
played an important role, and may dominate in some film systems. The final
strain states within epitaxial films were the result of competition between
multiple mechanisms and may not be described by a single parameter.Comment: REVTeX4, 14 figure
Minor Review: An Overview of a Synthetic Nanophase Bone Substitute
Material is reviewed that consists of reconstituted collagen fibril gel mineralized in a manner that produces biomimetically sized nanoapatites intimately associated with the fibrils. This gel is formed into usable shapes with a modulus and strength that allow it to be surgically press fitted into bony defects. The design paradigm for the material is that the nanoapatites will dissolve into soluble Ca2+ as the collagen is degraded into RGD-containing peptide fragments due to osteoclastic action. This is intended to signal to the osteoclasts to continue removing the material in a biomimetic fashion similar to bony remodeling. Preliminary experiments in a subcutaneous rat model show that the material is biocompatible with respect to inflammatory and immunogenic responses, and that it supports cellular invasion. Preliminary experiments in a critical-sized mandibular defect in rats show that the material is resorbable and functions well as a bone morphogenetic 2 (BMP-2) carrier. We have produced a range of mechanical and biological responses by varying mechanical and chemical processing of the material
Absence of correlation between built-in electric dipole moment and quantum Stark effect in InAs/GaAs self-assembled quantum dots
We report significant deviations from the usual quadratic dependence of the
ground state interband transition energy on applied electric fields in
InAs/GaAs self-assembled quantum dots. In particular, we show that conventional
second-order perturbation theory fails to correctly describe the Stark shift
for electric field below kV/cm in high dots. Eight-band calculations demonstrate this effect is predominantly due to
the three-dimensional strain field distribution which for various dot shapes
and stoichiometric compositions drastically affects the hole ground state. Our
conclusions are supported by two independent experiments.Comment: 4 pages, 4 figure
Multiband theory of multi-exciton complexes in self-assembled quantum dots
We report on a multiband microscopic theory of many-exciton complexes in
self-assembled quantum dots. The single particle states are obtained by three
methods: single-band effective-mass approximation, the multiband
method, and the tight-binding method. The electronic structure calculations are
coupled with strain calculations via Bir-Pikus Hamiltonian. The many-body wave
functions of electrons and valence holes are expanded in the basis of
Slater determinants. The Coulomb matrix elements are evaluated using statically
screened interaction for the three different sets of single particle states and
the correlated -exciton states are obtained by the configuration interaction
method. The theory is applied to the excitonic recombination spectrum in
InAs/GaAs self-assembled quantum dots. The results of the single-band
effective-mass approximation are successfully compared with those obtained by
using the of and tight-binding methods.Comment: 10 pages, 8 figure
A Common Genetic Variant (97906C>A) of DAB2IP/AIP1 Is Associated with an Increased Risk and Early Onset of Lung Cancer in Chinese Males
DOC-2/DAB2 interactive protein (DAB2IP) is a novel identified tumor suppressor gene that inhibits cell growth and facilitates cell apoptosis. One genetic variant in DAB2IP gene was reported to be associated with an increased risk of aggressive prostate cancer recently. Since DAB2IP involves in the development of lung cancer and low expression of DAB2IP are observed in lung cancer, we hypothesized that the variations in DAB2IP gene can increase the genetic susceptibility to lung cancer. In a case-control study of 1056 lung cancer cases and 1056 sex and age frequency-matched cancer-free controls, we investigated the association between two common polymorphisms in DAB2IP gene (−1420T>G, rs7042542; 97906C>A, rs1571801) and the risk of lung cancer. We found that compared with the 97906CC genotypes, carriers of variant genotypes (97906AC+AA) had a significant increased risk of lung cancer (adjusted odds ratio [OR] = 1.33, 95%CI = 1.04–1.70, P = 0.023) and the number of variant (risk) allele worked in a dose-response manner (Ptrend = 0.0158). Further stratification analysis showed that the risk association was more pronounced in subjects aged less than 60 years old, males, non-smokers, non-drinkers, overweight groups and in those with family cancer history in first or second-degree relatives, and the 97906A interacted with overweight on lung cancer risk. We further found the number of risk alleles (97906A allele) were negatively correlated with early diagnosis age of lung cancer in male patients (P = 0.003). However, no significant association was observed on the −1420T>G polymorphism. Our data suggested that the 97906A variant genotypes are associated with the increased risk and early onset of lung cancer, particularly in males
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