Additional file 1: of CT characteristics of non-small cell lung cancer with epidermal growth factor receptor mutation: a systematic review and meta-analysis

PRISMA-checklist. (DOC 67 kb

A 74 year old male patient with H7N9 pneumonia from mortality group.

<p>Chest radiograph with score of 28 shows bilateral patchy consolidations and ground glass opacities.</p

ROC analysis of the CT score for prediction of mortality.

<p>N = 22; AUC = 0.833.</p

Demorgraphics, comorbidities, and clinical presentations in mortality and survival groups.

<p>**<i>P</i><0.01 versus survival group.</p><p>Percentages are in parentheses, unless indicated as IQR (interquartile range).</p

Chest radiographic features in mortality and survival groups.

<p>*<i>P</i><0.05 versus survival group.</p><p>Percentages are in parentheses, unless indicated as IQR (interquartile range).</p><p>GGO: ground grass opacity.</p

Initial and follow-up CT features of 12 patients in survival group.

<p>*<i>P</i><0.05 versus survival group.</p><p>Percentages are in parentheses, unless indicated as IQR (interquartile range).</p><p>GGO: ground grass opacity.</p

ROC analysis of the chest radiographic score for prediction of mortality.

<p>N = 22; AUC  = 0.738.</p

The schematic of CT scoring system.

<p>Schematic coronal representations of zones, extent of ground-glass opacity and consolidation on an axial image, and a sample scoring on an axial CT image. Schematic coronal representation of zones (A) evaluated in the lungs of patients with H7N9 infection shows upper zones which are above the carina, middle zones between the carina and the inferior pulmonary vein, and lower zones which are below the inferior pulmonary vein. Schematic representation of the extent of ground-glass opacity (GGO) and consolidation (CO) on an axial image (B) which were determined using the modified Grieser system. Points from all zones were added for a cumulative score, with value ranging from 0 to 72. A sample scoring on an axial CT image (C) of a 52-year-old woman from mortality group demonstrates a total score of 18, calculated as 3 (consolidation, solid arrow) ×4 (>75% distribution in middle zone of the right lung) +2 (ground-glass opacity, open arrow) ×1 (<25% distribution in middle zone of the right lung) +2 (ground-glass opacity, open arrow) ×2 (25–50% distribution in middle zone of the left lung).</p

A 53 year old male patient with H7N9 pneumonia from survival group.

<p>CT images with CT score of 18 show ground glass opacity mostly in the upper zones (A) and consolidation in the lower zones (B).</p

CT features in mortality and survival groups.

<p>*<i>P</i><0.05 versus survival group.</p><p>Percentages are in parentheses, unless indicated as IQR (interquartile range).</p><p>GGO: ground grass opacity.</p