42 research outputs found
Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams
The enantioselective synthesis of nitrogen-containing heterocycles (N-heterocycles) represents a substantial chemical research effort and resonates across numerous disciplines, including the total synthesis of natural products and medicinal chemistry. In this Article, we describe the highly enantioselective palladium-catalysed decarboxylative allylic alkylation of readily available lactams to form 3,3-disubstituted pyrrolidinones, piperidinones, caprolactams and structurally related lactams. Given the prevalence of quaternary N-heterocycles in biologically active alkaloids and pharmaceutical agents, we envisage that our method will provide a synthetic entry into the de novo asymmetric synthesis of such structures. As an entry for these investigations we demonstrate how the described catalysis affords enantiopure quaternary lactams that intercept synthetic intermediates previously used in the synthesis of the Aspidosperma alkaloids quebrachamine and rhazinilam, but that were previously only available by chiral auxiliary approaches or as racemic mixtures
Pre-oxygenation enhances induction with sevoflurane as assessed using bispectral index monitoring
RESPIRATORY CHARACTERISTICS AND HEMODYNAMIC RESPONSE DURING HIGH CONCENTRATION VITAL CAPACITY GASEOUS INDUCTION WITH SEVOFLURANE IN PATIENTS UNDERGOING CABG SURGERY
Silyl Cyanopalladate-Catalyzed Friedel–Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives
A comparison between single- and double-breath vital capacity inhalation induction with 8% sevoflurane in children
High concentration sevoflurane induction of anesthesia accelerates onset of vecuronium neuromuscular blockade
Inhalational induction with isoflurane: The influence of lidocaine pretreatment
10.1007/BF02483348Journal of Anesthesia102125-128JOAN