Strategy of mine ventilation control in optimal mode using fuzzy logic controllers

The issues related to improving the efficiency of automatic ventilation control systems of mines that regulate the air supply to the mine in accordance with the need are considered. During the tests of such a system in the 3RU mine of OAO Belaruskali, the shortcomings of its existing, implementation, associated with the incorrect choice of the most difficult-to-ventilate direction, were revealed. The possibilities of implementing a control strategy, in which the system automatically determines the optimal configuration of the operating modes of fans and regulators, are demonstrated. As an alternative to the implemented algorithms, it is proposed to use a fuzzy control device to account for the nonlinearity of the dependence of the input and output parameters of ventilation equipment and to set the conditions for the optimal operating mode of the system in a declarative form. To assess the effectiveness of the proposed approach, the data of simulation modeling of the current ventilation mode and the transition from one ventilation mode to another are analyzed with comparison with the actual data of the system operation. The simulation results show that the use of an upgraded control scheme for the main ventilation fan based on fuzzy logic in the implementation of automatic ventilation control systems makes it possible to eliminate the possibility of a shortage of fresh air in the regulated directions of its movement, as well as excessive power consumption of the main ventilation fan

Repressive Poetics: Genesis and Representativeness

В статье «Репрессивная поэтика: генезис и репрезентативность» рассматривается феномен репрессивной поэтики, его ключевые компоненты и особенности функционирования в современном социуме. Особое внимание уделяется историко-философскому осмыслению поэтики как культурного феномена (в частности, рассматриваются идеи Платона, Аристотеля, Хайдеггера) и, кроме того, анализируется ряд лингвистических и философских концепций феномена образа как имманентного свойства поэтики. Предлагается понятийное определение «репрессивной поэтики» и «репрессивного образа». Репрезентативность репрессивной поэтики в современной культуре иллюстрируется на примере городского мифа

Tumor-Induced T Cell Polarization by Schwann Cells

Nerve-cancer crosstalk resulting in either tumor neurogenesis or intratumoral neurodegeneration is critically controlled by Schwann cells, the principal glial cells of the peripheral nervous system. Though the direct stimulating effect of Schwann cells on malignant cell proliferation, motility, epithelial–mesenchymal transition, and the formation of metastases have been intensively investigated, the ability of Schwann cells to affect the effector and regulatory immune cells in the tumor environment is significantly less studied. Here, we demonstrated that tumor cells could stimulate Schwann cells to produce high levels of prostaglandin E, which could be blocked by COX-2 inhibitors. This effect was mediated by tumor-derived TGF-β as neutralization of this cytokine in the tumor-conditioned medium completely blocked the inducible prostaglandin E production by Schwann cells. Similar protective effects were also induced by the Schwann cell pretreatment with TGF-βR1/ALK4/5/7 and MAPK/ERK kinase inhibitors of the canonical and non-canonical TGF-β signaling pathways, respectively. Furthermore, prostaglandin E derived from tumor-activated Schwann cells blocked the proliferation of CD3/CD28-activated T cells and upregulated the expression of CD73 and PD-1 on both CD4+ and CD8+ T cells, suggesting T cell polarization to the exhausted phenotype. This new pathway of tumor-induced T cell inhibition via the activation of neuroglial cells represents new evidence of the importance of nerve–cancer crosstalk in controlling tumor development and progression. A better understanding of the tumor-neuro-immune axis supports the development of efficient targets for harnessing this axis and improving the efficacy of cancer therapy

Repressive Poetics: Genesis and Representativeness

В статье «Репрессивная поэтика: генезис и репрезентативность» рассматривается феномен репрессивной поэтики, его ключевые компоненты и особенности функционирования в современном социуме. Особое внимание уделяется историко-философскому осмыслению поэтики как культурного феномена (в частности, рассматриваются идеи Платона, Аристотеля, Хайдеггера) и, кроме того, анализируется ряд лингвистических и философских концепций феномена образа как имманентного свойства поэтики. Предлагается понятийное определение «репрессивной поэтики» и «репрессивного образа». Репрезентативность репрессивной поэтики в современной культуре иллюстрируется на примере городского мифа

Slowing of the HIV epidemic in Ukraine: Evidence from case reporting and key population surveys, 2005-2012

Conclusions: This analysis suggests that Ukraine's HIV epidemic has slowed, with decreasing reported cases and older cases predominating among those diagnosed. Recent decreases in cases and in prevalence support decreased incidence among young PWID and wo

Slowing of the HIV epidemic in Ukraine: evidence from case reporting and key population surveys, 2005-2012.

Ukraine developed Europe's most severe HIV epidemic due to widespread transmission among persons who inject drugs (PWID). Since 2004, prevention has focused on key populations; antiretroviral therapy (ART) coverage has increased. Recent data show increases in reported HIV cases through 2011, especially attributed to sexual transmission, but also signs of potential epidemic slowing. We conducted a data triangulation exercise to better analyze available data and inform program implementation.We reviewed data for 2005 to 2012 from multiple sources, primarily national HIV case reporting and integrated biobehavioral surveillance (IBBS) studies among key populations. Annually reported HIV cases increased at a progressively slower rate through 2011 with recent increases only among older, more immunosuppressed individuals; cases decreased 2.7% in 2012. Among women <25 years of age, cases attributed to heterosexual transmission and HIV prevalence in antenatal screening declined after 2008. Reported cases among young PWID declined by three-fourths. In 2011, integrated biobehavioral surveillance demonstrated decreased HIV prevalence among young members of key populations compared with 2009. HIV infection among female sex workers (FSW) remains strongly associated with a personal history of injecting drug use (IDU).This analysis suggests that Ukraine's HIV epidemic has slowed, with decreasing reported cases and older cases predominating among those diagnosed. Recent decreases in cases and in prevalence support decreased incidence among young PWID and women. Trends among heterosexual men and men who have sex with men (MSM) are less clear; further study and enhanced MSM prevention are needed. FSW appear to have stable prevalence with risk strongly associated with IDU. Current trends suggest the Ukrainian epidemic can be contained with enhanced prevention among key populations and increased treatment access

HIV surveillance among IDU<25 years of age, Ukraine.

<p>a. Reported HIV cases by sex, 2005–2012. b. HIV prevalence in IBBS by region: 2008/2009 and 2011.</p

Reported HIV cases among adults and adolescents, Ukraine 1995–2012.

<p>Reported HIV cases among adults and adolescents, Ukraine 1995–2012.</p

HIV prevalence among pregnant women at initial antenatal screening and at delivery, Ukraine 1995–2012.

<p>HIV prevalence among pregnant women at initial antenatal screening and at delivery, Ukraine 1995–2012.</p