Associations Between Mindful Eating Techniques And Gestational Weight Gain

Abstract Objective: To investigate the extent to which the use of mindful eating techniques is associated with gestational weight gain among a clinic-based sample of pregnant women. Methods: Four hundred and forty-eight pregnant women in their second trimester of pregnancy participated in the Expect With Me group care study and were selected for this secondary analysis. Sociodemographic and general health data was collected at baseline. Mindfulness practice was measured based on frequency of performing mindful thinking and mindful eating techniques in the third trimester. The main outcome was excessive average weekly gestational weight gain, which was determined using the guidelines published by Institute of Medicine in 2009. Results: Among control variables, compared to White women, women in other race had 0.29 times the odds (95%CI: 0.14-0.64) to gain excessive weight. Controlling for sociodemographic and behavioral factors, women who entered pregnancy overweight or obese had 3.48 times the odds (95%CI 2.05-1.09) and 2.30 times the odds (95%CI 1.44-3.06) of gaining excessive gestational weight compared to who were normal weight, respectively. Participants paying attention to physical hunger and fullness had 1.66 times the odds (95%CI: 1.09-2.53) of excessive gestational weight gain. Conclusion: Mindful eating practices were observed more commonly among women who gained weight in excess of gestational weight gain guidelines. Further research is needed to understand the temporality of this association, specifically whether mindful eating practices were, in fact, adopted as a strategy for managing excess weight gain rather than as a preventative measure

Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus

Nearly all motile cilia contain a central apparatus (CA) composed of two connected singlet microtubules with attached projections that play crucial roles in regulating ciliary motility. Defects in CA assembly usually result in motility-impaired or paralyzed cilia, which in humans causes disease. Despite their importance, the protein composition and functions of the CA projections are largely unknown. Here, we integrated biochemical and genetic approaches with cryo-electron tomography to compare the CA of wild-type Chlamydomonas with CA mutants. We identified a large ( \u3e 2 MD) complex, the C1a-e-c supercomplex, that requires the PF16 protein for assembly and contains the CA components FAP76, FAP81, FAP92, and FAP216. We localized these subunits within the supercomplex using nanogold labeling and show that loss of any one of them results in impaired ciliary motility. These data provide insight into the subunit organization and 3D structure of the CA, which is a prerequisite for understanding the molecular mechanisms by which the CA regulates ciliary beating

Effect of shallow cumulus convection on the eastern Pacific climate in a coupled model

Shallow cumulus convection evaporates stratocumulus clouds in the atmospheric boundary layer. The effect of shallow convection on the large-scale climate of the eastern tropical Pacific is investigated with a coupled ocean-atmosphere model by disabling the shallow convection parameterization (noSC). Without shallow convection, the stratiform cloud fraction increases and surface solar radiation decreases. The sea surface temperature (SST) cools on average by 2°C. The cooling in noSC is larger under the low cloud deck south of the equator than north of the equator, resulting in an increase in the climatic meridional asymmetry. In the control run an ITCZ forms south of the equator in March-April. In noSC the SST is at most 24°C south of the equator and an ITCZ does not form. The perennial northern-hemisphere ITCZ in noSC is accompanied by year-round southerlies of at least ~3 m s⁻¹ on the equator, considerably reducing the seasonal cycle of equatorial SST

Identification of DNA-binding protein based multiple kernel model

DNA-binding proteins (DBPs) play a critical role in the development of drugs for treating genetic diseases and in DNA biology research. It is essential for predicting DNA-binding proteins more accurately and efficiently. In this paper, a Laplacian Local Kernel Alignment-based Restricted Kernel Machine (LapLKA-RKM) is proposed to predict DBPs. In detail, we first extract features from the protein sequence using six methods. Second, the Radial Basis Function (RBF) kernel function is utilized to construct pre-defined kernel metrics. Then, these metrics are combined linearly by weights calculated by LapLKA. Finally, the fused kernel is input to RKM for training and prediction. Independent tests and leave-one-out cross-validation were used to validate the performance of our method on a small dataset and two large datasets. Importantly, we built an online platform to represent our model, which is now freely accessible via http://8.130.69.121:8082/

Numerical Simulation of Boundary Layer Structure and Cross-Equatorial Flow in the Eastern Pacific

Recent observations from spaceborne microwave sensors have revealed detailed structure of the surface flow over the equatorial eastern Pacific in the boreal fall season. A marked acceleration of surface wind across the northern sea surface temperature (SST) front of the cold tongue is a prominent feature of the regional climate. Previous studies have attributed the acceleration to the effect of enhanced momentum mixing over the warmer waters. A high-resolution numerical model is used to examine the cross-frontal flow adjustment. In a comprehensive comparison, the model agrees well with many observed features of crossequatorial flow and boundary layer structure from satellite, Tropical Atmosphere Ocean (TAO) moorings, and the recent Eastern Pacific Investigation of Climate Processes (EPIC) campaign. In particular, the model simulates the acceleration across the SST front, and the change from a stable to unstable boundary layer. Analysis of the model momentum budget indicates that the hydrostatic pressure gradient, set up in response to the SST gradient, drives the surface northward acceleration. Because of thermal advection by the mean southerly flow, the pressure gradient is located downstream of the SST gradient and consequently, divergence occurs over the SST front, as observed by satellite. Pressure gradients also act to change the vertical shear of the wind as the front is crossed. However, the model underpredicts the changes in vertical wind shear across the front, relative to the EPIC observations. It is suggested that the vertical transfer of momentum by mixing, a mechanism described by Wallace et al. may also act to enhance the change in shear in the observations, but the model does not simulate this effect. Reasons for this are discussed

Optical and Near-Infrared Observations of the Highly Reddened, Rapidly Expanding Type Ia Supernova 2006X in M100

We present extensive optical (UBVRI), near-infrared (JK) light curves and optical spectroscopy of the Type Ia supernova (SN) 2006X in the nearby galaxy NGC 4321 (M100). Our observations suggest that either SN 2006X has an intrinsically peculiar color evolution, or it is highly reddened [E(B - V)_{host} = 1.42+/-0.04 mag] with R_V = 1.48+/-0.06, much lower than the canonical value of 3.1 for the average Galactic dust. SN 2006X also has one of the highest expansion velocities ever published for a SN Ia. Compared with the other SNe Ia we analyzed, SN 2006X has a broader light curve in the U band, a more prominent bump/shoulder feature in the V and R bands, a more pronounced secondary maximum in the I and near-infrared bands, and a remarkably smaller late-time decline rate in the B band. The B - V color evolution shows an obvious deviation from the Lira-Phillips relation at 1 to 3 months after maximum brightness. At early times, optical spectra of SN 2006X displayed strong, high-velocity features of both intermediate-mass elements (Si, Ca, and S) and iron-peak elements, while at late times they showed a relatively blue continuum, consistent with the blue U-B and B-V colors at similar epochs. A light echo and/or the interaction of the SN ejecta and its circumstellar material may provide a plausible explanation for its late-time photometric and spectroscopic behavior. Using the Cepheid distance of M100, we derive a Hubble constant of 72.7+/-8.2 km s^{-1} Mpc^{-1}(statistical) from the normalized dereddened luminosity of SN 2006X. We briefly discuss whether abnormal dust is a universal signature for all SNe Ia, and whether the most rapidly expanding objects form a subclass with distinct photometric and spectroscopic properties.Comment: 48 pages, 20 figures and 11 tables. Accepted Version (ApJ, 2008, March issue

Rapid detection of porcine circovirus type 4 via multienzyme isothermal rapid amplification

Porcine circovirus type 4 (PCV4) is a newly emerging pathogen that was first detected in 2019 and is associated with diverse clinical signs, including respiratory and gastrointestinal distress, dermatitis and various systemic inflammations. It was necessary to develop a sensitive and specific diagnostic method to detect PCV4 in clinical samples, so in this study, a multienzyme isothermal rapid amplification (MIRA) assay was developed for the rapid detection of PCV4 and evaluated for sensitivity, specificity and applicability. It was used to detect the conserved Cap gene of PCV4, operated at 41°C and completed in 20 min. With the screening of MIRA primer-probe combination, it could detect as low as 101 copies of PCV4 DNA per reaction and was highly specific, with no cross-reaction with other pathogens. Further assessment with clinical samples showed that the developed MIRA assay had good correlation with real-time polymerase chain reaction assay for the detection of PCV4. The developed MIRA assay will be a valuable tool for the detection of the novel PCV4 in clinical samples due to its high sensitivity and specificity, simplicity of operation and short testing time

Gate-Compatible Circuit QED in a Three-Dimensional Cavity Architecture

Semiconductor-based superconducting qubits offer a versatile platform for studying hybrid quantum devices in circuit quantum electrodynamics (cQED) architecture. Most of these cQED experiments utilize coplanar waveguides, where the incorporation of DC gate lines is straightforward. Here, we present a technique for probing gate-tunable hybrid devices using a three-dimensional (3D) microwave cavity. A recess is machined inside the cavity wall for the placement of devices and gate lines. We validate this design using a hybrid device based on an InAs-Al nanowire Josephson junction. The coupling between the device and the cavity is facilitated by a long superconducting strip, the antenna. The Josephson junction and the antenna together form a gatemon qubit. We further demonstrate the gate-tunable cavity shift and two-tone qubit spectroscopy. This technique could be used to probe various quantum devices and materials in a 3D cQED architecture that requires DC gate voltages

Dbh+ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function. Yet the biological and physiological identities and the origin of the specialized cardiomyocyte populations have not been fully comprehended. Here we report a previously unrecognised population of cardiomyocytes expressing Dbhgene encoding dopamine beta-hydroxylase in murine heart. We determined how these myocytes are distributed across the heart by utilising advanced single-cell and spatial transcriptomic analyses, genetic fate mapping and molecular imaging with computational reconstruction. We demonstrated that they form the key functional components of the cardiac conduction system by using optogenetic electrophysiology and conditional cardiomyocyte Dbh gene deletion models. We revealed their close relationship with sympathetic innervation during cardiac conduction system formation. Our study thus provides new insights into the development and heterogeneity of the mammalian cardiac conduction system by revealing a new cardiomyocyte population with potential catecholaminergic endocrine function