Why do supply chain technologies sometimes fail to improve a firm’s performance?

Successful implementation depends on the reason why the technology was adopted in the first place, write Zhongzhi Liu, Daniel Prajogo, and Adegoke Ok

Additional file 1: of Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

Figure S1. The cell numbers of RU cells derived from SupM2 and Karpas 299 upon various doses of H2O2 treatment were counted by trypan blue exclusion assay from day 0 to day 3. (PDF 79 kb

Additional file 5: of Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

Figure S5. The activation levels of ALK and STAT3 were inappreciably changed upon H2O2 re-challenge. The expression levels of pALKY1604, ALK, pSTAT3Y705, and STAT3 in RU and RR cells with or without H2O2 re-challenge. The same cell lysates from Fig. 3a were reused in this experiment, and note that the same β-actin blot as the one in Fig. 3a was recycled for H2O2-stimulation in RU and RR cells derived from Karpas 299 cells. (PDF 102 kb

Additional file 2: of Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

Figure S2. Anti-oxidant reagent NAC blocked the increase of GFP-positive cells induced by H2O2. A-B) Treatment of NAC abrogated the increased GFP-positive cells induced by 0.3 mM H2O2 for 48 h in RU cells derived from SupM2 in a NAC-dose dependent manner, read by GFP expression (A) and luciferase activity (B). (PDF 55 kb

Additional file 6: of Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

Figure S6. RU cells derived from SupM2 were transfected with either Sox2 siRNA or scrambled siRNA which served as a negative control. Cells after siRNA transfection were exposed to 0.3 mM H2O2 re-challenge. At day 4 of the H2O2 re-challenge experiment; cells were subjected to 200 ng/mL doxorubicin for additional 48 h, following by the trypan blue exclusion assay-based cell viability analysis. The Western blots in the right panel demonstrated the Sox2 knockdown efficiency in RU cells from SupM2 24 h post transfection. (PDF 48 kb