69 research outputs found
3,4-Dihydroxy-N′-(2-hydroxybenzylidene)benzohydrazide–methanol–water (2/1/3)
The asymmetric unit of the title compound, C14H12N2O4·0.5CH4O·1.5H2O, consists of two Schiff base molecules, three water molecules and one methanol molecule. The dihedral angle between the two benzene rings is 7.8 (2)° in one of the molecules and 4.0 (2)° in the other. Intramolecular O—H⋯O and O—H⋯N hydrogen bonds are observed. Molecules are linked into a three-dimensional network by O—H⋯O and N—H⋯O intermolecular hydrogen bonds
N′-(4-Methoxybenzylidene)-4-nitrobenzohydrazide methanol solvate
The title compound, C15H13N3O4·CH4O, was synthesized from the reaction of 4-methoxybenzaldehyde with 4-nitrobenzohydrazide in methanol. The benzene rings of the Schiff base molecule are nearly coplanar, making a dihedral angle of 7.0 (3)°. The methanol solvent molecules are linked to the Schiff base molecules by N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, forming chains running parallel to the b axis
3,5-Dihydroxy-N′-[(2-hydroxy-1-naphthyl)methylene]benzohydrazide
In the title compound, C18H14N2O4, the dihedral angle between the benzene ring and the naphthyl ring system is 10.1 (2)°. The molecule is nearly planar, with a mean deviation from the plane of 0.141 (2) Å for 24 non-H atoms. An intramolecular O—H⋯N hydrogen bond forms a pseudo-6-membered ring and the molecules are linked into sheets by intermolecular N—H⋯O and O—H⋯O hydrogen bonds
N′-(2-Hydroxy-5-chlorobenzylidene)-4-nitrobenzohydrazide methanol solvate
The title compound, C14H10ClN3O4·CH4O, was synthesized from the reaction of 5-chlorosalicylaldehyde with 4-nitrobenzohydrazide in methanol. The Schiff base molecule is nearly planar, with a dihedral angle of 9.1 (3)° between the two benzene rings. The methanol solvent molecules are linked to the Schiff base molecules by N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, forming chains running parallel to the a axis
2,4-Dihydroxy-N′-(4-methoxybenzylidene)benzohydrazide
The molecule of the title compound, C15H14N2O4, displays a trans configuration with respect to the hydrazide C=N bond. The dihedral angle between the two benzene rings is 15.0 (2)°. In the crystal structure, molecules are linked through intermolecular O—H⋯N and O—H⋯O hydrogen bonds, forming layers parallel to the ab plane; an intramolecular N—H⋯O hydrogen bond is also present
(E)-4-Bromo-N′-(2-hydroxy-1-naphthylmethylene)benzohydrazide
The title compound, C18H13BrN2O2, was synthesized by the reaction of 2-hydroxy-1-naphthaldehyde with 4-bromobenzohydrazide. This Schiff base molecule has an E configuration about the C=N bond and is almost planar, the dihedral angle between the mean planes through the substituted benzene ring and the naphthyl system being 6.6 (2)°. There is an intramolecular O—H⋯N hydrogen bond involving the naphthyl hydroxy substituent and the N′ atom of the hydrazide group. In the crystal structure, molecules are linked through intermolecular N—-H⋯O hydrogen bonds to form chains extending along the b direction
(E)-N′-(2,5-Dimethoxybenzylidene)-2-(8-quinolyloxy)acetohydrazide methanol solvate
The two molecules in the asymmetric unit of the title compound, C20H19N3O4·CH4O, are paired via O—H⋯(O,N), N—H⋯O, and C—H⋯O hydrogen bonds. The molecular skeleton of the acetohydrazide molecule is close to planar; the benzene and quinoline mean planes form a dihedral angle of 3.9 (3)°. The crystal packing exhibits weak intermolecular C—H⋯O hydrogen bonds and π–π interactions, indicated by short distances of 3.668 (3) Å, between the centroids of N-containing six-membered rings from neighbouring acetohydrazide molecules
SIMULTANEOUS DETERMINATION OF CONTENTS OF THREE ACTIVE COMPONENTS IN JIEJIA TINCTURE BY HPLC METHOD
The objective of the study was to determine the contents of three active components in Jiejia tincture by establishing HPLC method. Test articles were prepared by ultrasonic extraction. Separation was performed using a Kromasil C18 (250 mm × 4.6 mm, 5 μm) chromatographic column, and gradient elution was performed with acetonitrile-0.3% phosphoric acid solution as the mobile phase at a volumetric flow rate of 0.80 mL/min. The contents of catechin, baicalin and berberine in Jiejia tincture were determined at the wavelength of 276 nm and a column temperature of 30 ℃. The results revealed that catechin showed a good linear relationship at the range of 100~800 μg/mL (r=0.9997); baicalin showed a good linear relationship at the range of 15~120 μg/mL (r=0.9996), and berberine at the range of 7~56 μg/mL (r=0.9995). Their average recovery rates were 99.67% (RSD 1.01%, n=6), 98.7% (RSD 1.93%, n=6) and 100.5% (RSD 2.88%, n=6) respectively. The study concluded that the high-performance liquid chromatography established in this study was simple, accurate and reproducible, and can also be used in the determination of catechin, baicalin and berberine contents in Jiejia tincture
(E)-4-Bromo-N′-(2-chlorobenzylidene)benzohydrazide
In the title compound, C14H10BrClN2O, the dihedral angle between the two benzene rings is 11.4 (2)°. In the crystal structure, molecules are connected via intermolecular N—H⋯O hydrogen bonds into one-dimensional chains running parallel to the c axis
(E)-N′-(5-Chloro-2-hydroxybenzylidene)-3,5-dihydroxybenzohydrazide monohydrate
In the title compound, C14H11ClN2O4·H2O, the dihedral angle between the two benzene rings is 8.5 (2)° and an intramolecular O—H⋯N hydrogen bond is observed in the Schiff base molecule. In the crystal structure, the water molecule accepts an N—H⋯O hydrogen bond and makes O—H⋯O hydrogen bonds to two further Schiff base molecules. Further intermolecular O—H⋯O hydrogen bonds lead to the formation of layers parallel to the bc plane
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