Case report: An N-of-1 study using amplitude modulated transcranial alternating current stimulation between Broca's area and the right homotopic area to improve post-stroke aphasia with increased inter-regional synchrony

Over one-third of stroke survivors develop aphasia, and language dysfunction persists for the remainder of their lives. Brain language network changes in patients with aphasia. Recently, it has been reported that phase synchrony within a low beta-band (14–19 Hz) frequency between Broca's area and the homotopic region of the right hemisphere is positively correlated with language function in patients with subacute post-stroke aphasia, suggesting that synchrony is important for language recovery. Here, we employed amplitude-modulated transcranial alternating current stimulation (AM-tACS) to enhance synchrony within the low beta band frequency between Broca's area and the right homotopic area, and to improve language function in a case of chronic post-stroke aphasia. According to an N-of-1 study design, the patient underwent short-term intervention with a one-time intervention of 15 Hz-AM-tACS with Broca's and the right homotopic areas (real condition), sham stimulation (sham condition), and 15 Hz-AM-tACS with Broca's and the left parietal areas (control condition) and long-term intervention with sham and real conditions (10 sessions in total, each). In the short-term intervention, the reaction time and accuracy rate of the naming task improved after real condition, not after sham and control conditions. The synchrony between the stimulated areas evaluated by coherence largely increased after the real condition. In the long-term intervention, naming ability, verbal fluency and overall language function improved, with the increase in the synchrony, and those improvements were sustained for more than a month after real condition. This suggests that AM-tACS on Broca's area and the right homotopic areas may be a promising therapeutic approach for patients with poststroke aphasia

Christopher Simpson The Division-Viol, or, The Art of PLAYING Extempore upon a GROUND. EDITIO SECVNDA Dedication & Recommendation

本訳稿はChristopher Simpson (1605頃－1669) 著 The Division-Viol, or, The Art of PLAYING Ex tempore upon a GROUND. DIVIDED INTO THREE PARTS. EDITIO SECVNDA, London, 1665 の著者による献辞および楽譜出版権所有者による推薦文の全訳である

Recurrence of Atrial Fibrillation within Three Months after Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation : Analysis Using an External Loop Recorder with Auto-trigger Function

Pulmonary vein isolation (PVI) via catheter ablation has been shown to be a highly effective option for patients with symptomatic paroxysmal atrial brillation (AF). The recurrence of AF within 3 months after PVI is not considered a failure of the ablation procedure because early recurrence of AF is not always associated with late recurrence. We examined the usefulness of an external loop recorder with auto-trigger function (ELR-AUTO) to detect AF following PVI to characterize early recurrence and determine the implication of AF within 3 months after PVI. The study included 53 consecutive patients with symptomatic paroxysmal AF (age, 61.6 ± 12.6 years ; 77％ male) who underwent PVI, and were fitted with an ELR-AUTO for 7 ± 2 days within 3 months after PVI. Of the 33 patients(62.2％) who did not have AF within the 3-month period, only 1 patient had AF recurrence at 12 months. Seven of 20 patients (35％) who experienced AF within 3 months had symptomatic AF recurrence at 12 months. The sensitivity, specificity, positive predictive value, and negative predictive value of early AF recurrence for late recurrence was 87.5％, 71.1％, 35.0％, and 96.9％, respectively. Thus, AF recurrence detected by ELR-AUTO within 3 months after PVI can predict late AF recurrence. Freedom from AF in the firrst 3 months following ablation significantly predicts long-term freedom from AF. An ELR-AUTO is useful for detecting symptomatic and asymptomatic AF

A desterritorialização da redação no jornalismo contemporâneo

The displacement of writing emerged in urban centers due to its investment in technology and has been developed in major newspapers around the world. With the advent of the internet and technological development, the writing went from analog to digital. That made it no longer required the presence of the journalist in the physical redaction means modifying the various management structures of a writing routine and professional. This happened to capture, edit and distribute your notes, news and reports in online mode. This monograph aims to understand and define the macro change of virtualization in journalism, considering the stages of production of Le Monde Diplomatique, a newspaper whose writing is in process of deterritorialization, the people involved in this activity and the resources used and contributing to the debate on new forms of organization of an editorial environmentA desterritorialização da redação surgiu nos grandes centros urbanos devido ao seu investimento em tecnologia e vem sendo desenvolvido nos principais jornais do mundo. Com o advento da internet e o desenvolvimento tecnológico, a redação passou de analógica para digital. Isso fez com que não fosse mais obrigatória a presença do jornalista no meio redacional físico, modificando as diversas estruturas de gestão de uma redação e a rotina do profissional. Este passou a captar, editar e difundir suas notas, notícias e reportagens de modo online. Esta monografia objetiva entender e definir a macro mudança da virtualização no jornalismo, considerando as fases da produção do Le Monde Diplomatique, um jornal cuja redação encontra-se em processo de desterritorialização, as pessoas envolvidas nessa atividade e os recursos utilizados para a realização da mesma, e contribuir com o debate para as novas formas de organização de um ambiente redaciona

A desterritorialização da redação no jornalismo contemporâneo

The displacement of writing emerged in urban centers due to its investment in technology and has been developed in major newspapers around the world. With the advent of the internet and technological development, the writing went from analog to digital. That made it no longer required the presence of the journalist in the physical redaction means modifying the various management structures of a writing routine and professional. This happened to capture, edit and distribute your notes, news and reports in online mode. This monograph aims to understand and define the macro change of virtualization in journalism, considering the stages of production of Le Monde Diplomatique, a newspaper whose writing is in process of deterritorialization, the people involved in this activity and the resources used and contributing to the debate on new forms of organization of an editorial environmentA desterritorialização da redação surgiu nos grandes centros urbanos devido ao seu investimento em tecnologia e vem sendo desenvolvido nos principais jornais do mundo. Com o advento da internet e o desenvolvimento tecnológico, a redação passou de analógica para digital. Isso fez com que não fosse mais obrigatória a presença do jornalista no meio redacional físico, modificando as diversas estruturas de gestão de uma redação e a rotina do profissional. Este passou a captar, editar e difundir suas notas, notícias e reportagens de modo online. Esta monografia objetiva entender e definir a macro mudança da virtualização no jornalismo, considerando as fases da produção do Le Monde Diplomatique, um jornal cuja redação encontra-se em processo de desterritorialização, as pessoas envolvidas nessa atividade e os recursos utilizados para a realização da mesma, e contribuir com o debate para as novas formas de organização de um ambiente redaciona

Effectiveness of a Programmed Lecture on Self-Understanding of Emotion and Autonomy in Novice Nurses

Purpose: The purpose of this research was to verify the effectiveness of a lecture, which programmed for the ability promotion of interpersonal relationship and autonomy in novice nurses, in order to prevent early resignation and to establish high-quality nursing. Methods: This intervention program consisted of a lecture and a self-check exercise, and it took for 2 hours. To evaluate their emotional changes after the educational intervention program, the participants were asked to answer self-reporting questionnaires including Emotional intelligence Quotient Scale(EQS)and Nursing Autonomy Scale(NAS). Results: Out of 3 areas of“self-effect”,“human-relations”and “situation-reactions”, a significantly higher increase was observed in “situation-reaction”. Furthermore, out of 5 factors in NAS, each score of 4 factors except“Autonomic decision-making ability”and the total score significantly increased after the intervention. There was a significant correlation between the increases in scores of “Self-effect”of EQS and those in “Practice ability”of NAS after the intervention. Consideration: The lecture and self-check exercise were effective on self-understanding and autonomy in novice nurses