1 research outputs found

    Pleurocins A and B: Unusual 11(9 → 7)-<i>abeo</i>-Ergostanes and Eringiacetal B: A 13,14-<i>seco</i>-13,14-Epoxyergostane from Fruiting Bodies of <i>Pleurotus eryngii</i> and Their Inhibitory Effects on Nitric Oxide Production

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    Two novel 11(9 → 7)-<i>abeo</i>-ergostane-type steroids, named pleurocins A (<b>1</b>) and B (<b>2</b>), a 13,14-<i>seco</i>-13,14-epoxy ergostane, named eringiacetal B (<b>3</b>), and an ergostane steroid (<b>4</b>) were isolated from the fruiting bodies of <i>Pleurotus eryngii</i> (Pleurotaceae). Their structures were determined by spectroscopic data and X-ray crystallography. A possible biogenesis pathway for <b>1</b>–<b>3</b> was also described. Compounds <b>1</b>–<b>3</b> exhibited inhibitory activities against NO production with almost no cytotoxicity at concentrations lower than 30 μM
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