Surface micromachined electrostatically actuated micro peristaltic pump

An electrostatically actuated micro peristaltic pump is reported. The micro pump is entirely surface micromachined using a multilayer parylene technology. Taking advantage of the multilayer technology, the micro pump design enables the pumped fluid to be isolated from the electric field. Electrostatic actuation of the parylene membrane using both DC and AC voltages was demonstrated and applied to fluid pumping based on a 3-phase peristaltic sequence. A maximum flow rate of 1.7 nL min^–1 and an estimated pumping pressure of 1.6 kPa were achieved at 20 Hz phase frequency. A dynamic analysis was also performed with a lumped-parameter model for the peristaltic pump. The analysis results allow a quantitative understanding of the peristaltic pumping operation, and correctly predict the trends exhibited by the experimental data. The small footprint of the micro pump is well suited for large-scale integration of microfluidics. Moreover, because the same platform technology has also been used to fabricate other devices (e.g. valves, electrospray ionization nozzles, filters and flow sensors), the integration of these different devices can potentially lead to versatile and functional micro total analysis systems (µTAS)

Distributed Bootstrap for Simultaneous Inference Under High Dimensionality

We propose a distributed bootstrap method for simultaneous inference on high-dimensional massive data that are stored and processed with many machines. The method produces a $\ell_\infty$-norm confidence region based on a communication-efficient de-biased lasso, and we propose an efficient cross-validation approach to tune the method at every iteration. We theoretically prove a lower bound on the number of communication rounds $\tau_{\min}$ that warrants the statistical accuracy and efficiency. Furthermore, $\tau_{\min}$ only increases logarithmically with the number of workers and intrinsic dimensionality, while nearly invariant to the nominal dimensionality. We test our theory by extensive simulation studies, and a variable screening task on a semi-synthetic dataset based on the US Airline On-time Performance dataset. The code to reproduce the numerical results is available at GitHub: https://github.com/skchao74/Distributed-bootstrap.Comment: arXiv admin note: text overlap with arXiv:2002.0844

Parylene-strengthened thermal isolation technology for microfluidic system-on-chip applications

Here we reported a novel technology using parylene-cross-linking structure to achieve on-chip air-gap thermal isolation for microfluidic system-on-chip (SOC) applications. Two applications based on this technology, on-chip continuous-flow polymerase chain reaction (PCR) and on-chip temperature gradient liquid chromatography (LC) were successfully demonstrated. Device thermal performance in each example was characterized. Results showed that our technology not only provides excellent on-chip thermal isolation but also its simplicity of integration with other on-chip components makes versatile microfluidic SOC applications feasible