Sasaki-Einstein Twist of Kerr-AdS Black Holes

We consider Kerr-AdS black holes with equal angular momenta in arbitrary odd spacetime dimensions \ge 5. Twisting the Killing vector fields of the black holes, we reproduce the compact Sasaki-Einstein manifolds constructed by Gauntlett, Martelli, Sparks and Waldram. We also discuss an implication of the twist in string theory and M-theory.Comment: 7 pages; Added the Page limit metric and extra parameter \delta shown to be trivia

New Infinite Series of Einstein Metrics on Sphere Bundles from AdS Black Holes

A new infinite series of Einstein metrics is constructed explicitly on S^2 x S^3, and the non-trivial S^3-bundle over S^2, containing infinite numbers of inhomogeneous ones. They appear as a certain limit of a nearly extreme 5-dimensional AdS Kerr black hole. In the special case, the metrics reduce to the homogeneous Einstein metrics studied by Wang and Ziller. We also construct an inhomogeneous Einstein metric on the non-trivial S^{d-2}-bundle over S^2 from a d-dimensional AdS Kerr black hole. Our construction is a higher dimensional version of the method of Page, which gave an inhomogeneous Einstein metric on CP^2\sharp\bar{CP^2}.Comment: 15 pages, remarks and minor corrections adde

Applications of the Ashtekar gravity to four dimensional hyperk\"ahler geometry and Yang-Mills Instantons

The Ashtekar-Mason-Newman equations are used to construct the hyperk\"ahler metrics on four dimensional manifolds. These equations are closely related to anti self-dual Yang-Mills equations of the infinite dimensional gauge Lie algebras of all volume preserving vector fields. Several examples of hyperk\"ahler metrics are presented through the reductions of anti self-dual connections. For any gauge group anti self-dual connections on hyperk\"ahler manifolds are constructed using the solutions of both Nahm and Laplace equations.Comment: 9pages, Figures are not include

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the nuclear membrane is essential for normal cellular functioning. However, in cancer cells, the altered expression or localization of nuclear transporters as well as the disruption of endogenous nuclear transport inhibitors are some ways in which the Karyopherin proteins are dysregulated. The value of nuclear transporters in the diagnosis, prognosis and treatment of cancer is currently being elucidated with recent studies highlighting their potential as biomarkers and therapeutic targets

The relationship between pitching parameters and release points of different pitch types in major league baseball players

ObjectivesThe purpose of this study was to deepen our understanding of pitches and to obtain basic knowledge about pitches by comparing 4-seam and other pitches in Major League Baseball (MLB).MethodsWe analyzed big data for 1,820 professional baseball pitchers of MLB on release speed, spin rate, release point 3D coordinates (X, Y, and Z axes), amount of change for 4-seam, and seven changing ball types (sinker, slider, changeup, cutter, curve, split finger, and knuckle curve), using PITCHf/x and TrackMan. We also evaluated three relationships: (1) between the release points and the ball types of pitch; (2) between the amount of change in the ball and the release speed; and (3) between the release speed and the spin rate.ResultsThe release speed was significantly slower in seven changing ball types than in the 4-seam (p < 0.01, respectively). The spin rate and the amount of change (ΔX and ΔZ) were significantly different between 4-seam and seven changing ball types (p < 0.01, respectively). Release point 3D coordinates (X, Y, and Z axes) were significantly different between 4-seam and slider, cutter, and curve (p < 0.01, respectively). Based on these findings, the eight pitch types were mainly divided into three groups: 4-seam, curve, and off-speed pitch types.ConclusionSeven changing ball types included specific characteristics for each parameter. The correspondence among the release speed, ΔX, and ΔZ at the 3D coordinates is an arch with 4-seam as the apex. Our results suggest an effective strategy for changing the release point and displacement of a ball's trajectory to improve the performance of baseball pitchers

Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques

Background/Aims: To investigate the utility of a data-driven deep learning approach in patients with inherited retinal disorder (IRD) and to predict the causative genes based on fundus photography and fundus autofluorescence (FAF) imaging. / Methods: Clinical and genetic data from 1302 subjects from 729 genetically confirmed families with IRD registered with the Japan Eye Genetics Consortium were reviewed. Three categories of genetic diagnosis were selected, based on the high prevalence of their causative genes: Stargardt disease (ABCA4), retinitis pigmentosa (EYS) and occult macular dystrophy (RP1L1). Fundus photographs and FAF images were cropped in a standardised manner with a macro algorithm. Images for training/testing were selected using a randomised, fourfold cross-validation method. The application program interface was established to reach the learning accuracy of concordance (target: >80%) between the genetic diagnosis and the machine diagnosis (ABCA4, EYS, RP1L1 and normal). / Results: A total of 417 images from 156 Japanese subjects were examined, including 115 genetically confirmed patients caused by the three prevalent causative genes and 41 normal subjects. The mean overall test accuracy for fundus photographs and FAF images was 88.2% and 81.3%, respectively. The mean overall sensitivity/specificity values for fundus photographs and FAF images were 88.3%/97.4% and 81.8%/95.5%, respectively. / Conclusion: A novel application of deep neural networks in the prediction of the causative IRD genes from fundus photographs and FAF, with a high prediction accuracy of over 80%, was highlighted. These achievements will extensively promote the quality of medical care by facilitating early diagnosis, especially by non-specialists, access to care, reducing the cost of referrals, and preventing unnecessary clinical and genetic testing

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Identification of the sex-determining factor in the liverwort Marchantia polymorpha reveals unique evolution of sex chromosomes in a haploid system

半数体生物の性染色体上の性決定遺伝子を解明 --コケがもつ現生生物最古の起源の性染色体--. 京都大学プレスリリース. 2021-11-08.Sex determination is a central process for sexual reproduction and is often regulated by a sex determinant encoded on a sex chromosome. Rules that govern the evolution of sex chromosomes via specialization and degeneration following the evolution of a sex determinant have been well studied in diploid organisms. However, distinct predictions apply to sex chromosomes in organisms where sex is determined in the haploid phase of the life cycle: both sex chromosomes, female U and male V, are expected to maintain their gene functions, even though both are non-recombining. This is in contrast to the X-Y (or Z-W) asymmetry and Y (W) chromosome degeneration in XY (ZW) systems of diploids. Here, we provide evidence that sex chromosomes diverged early during the evolution of haploid liverworts and identify the sex determinant on the Marchantia polymorpha U chromosome. This gene, Feminizer, encodes a member of the plant-specific BASIC PENTACYSTEINE transcription factor family. It triggers female differentiation via regulation of the autosomal sex-determining locus of FEMALE GAMETOPHYTE MYB and SUPPRESSOR OF FEMINIZATION. Phylogenetic analyses of Feminizer and other sex chromosome genes indicate dimorphic sex chromosomes had already been established 430 mya in the ancestral liverwort. Feminizer also plays a role in reproductive induction that is shared with its gametolog on the V chromosome, suggesting an ancestral function, distinct from sex determination, was retained by the gametologs. This implies ancestral functions can be preserved after the acquisition of a sex determination mechanism during the evolution of a dominant haploid sex chromosome system