Eight Dimensional Noncommutative Instantons and D0-D8 Bound States with B-field

We construct some classes of instanton solutions of eight dimensional noncommutative ADHM equations generalizing the solutions of eight dimensional commutative ADHM equations found by Papadopoulos and Teschendorff, and interpret them as supersymmetric $D0$-$D8$ bound states in a NS $B$-field. Especially, we consider the $D0$-$D8$ system with anti-self-dual $B$-field preserving 3/16 of supercharges. This system and self-duality conditions are related with the group $Sp(2)$ which is a subgroup of the eight dimensional rotation group SO(8).Comment: 13 page

Cadherin activity is required for activity-induced spine remodeling

Neural activity induces the remodeling of pre- and postsynaptic membranes, which maintain their apposition through cell adhesion molecules. Among them, N-cadherin is redistributed, undergoes activity-dependent conformational changes, and is required for synaptic plasticity. Here, we show that depolarization induces the enlargement of the width of spine head, and that cadherin activity is essential for this synaptic rearrangement. Dendritic spines visualized with green fluorescent protein in hippocampal neurons showed an expansion by the activation of AMPA receptor, so that the synaptic apposition zone may be expanded. N-cadherin-venus fusion protein laterally dispersed along the expanding spine head. Overexpression of dominant-negative forms of N-cadherin resulted in the abrogation of the spine expansion. Inhibition of actin polymerization with cytochalasin D abolished the spine expansion. Together, our data suggest that cadherin-based adhesion machinery coupled with the actin-cytoskeleton is critical for the remodeling of synaptic apposition zone

Noncommutative U(1) Instantons in Eight Dimensional Yang-Mills Theory

We study the noncommutative version of the extended ADHM construction in the eight dimensional U(1) Yang-Mills theory. This construction gives rise to the solutions of the BPS equations in the Yang-Mills theory, and these solutions preserve at least 3/16 of supersymmetries. In a wide subspace of the extended ADHM data, we show that the integer $k$ which appears in the extended ADHM construction should be interpreted as the $D4$-brane charge rather than the $D0$-brane charge by explicitly calculating the topological charges in the case that the noncommutativity parameter is anti-self-dual. We also find the relationship with the solution generating technique and show that the integer $k$ can be interpreted as the charge of the $D0$-brane bound to the $D8$-brane with the $B$-field in the case that the noncommutativity parameter is self-dual.Comment: 22 page

Hypofractionated stereotactic radiotherapy for acoustic neuromas: safety and effectiveness over 8 years of experience.

Little information is available about long-term outcomes of hypofractionated stereotactic radiotherapy (hypo-FSRT) for acoustic neuromas. In this study, the safety and effectiveness of hypo-FSRT for unilateral acoustic neuroma were reviewed over 8 years of experience at our institution

CLICK:One-step generation of conditional knockout mice

Abstract Background CRISPR/Cas9 enables the targeting of genes in zygotes; however, efficient approaches to create loxP-flanked (floxed) alleles remain elusive. Results Here, we show that the electroporation of Cas9, two gRNAs, and long single-stranded DNA (lssDNA) into zygotes, termed CLICK (CRISPR with lssDNA inducing conditional knockout alleles), enables the quick generation of floxed alleles in mice and rats. Conclusions The high efficiency of CLICK provides homozygous knock-ins in oocytes carrying tissue-specific Cre, which allows the one-step generation of conditional knockouts in founder (F0) mice