27 research outputs found
Why Are Economics Students More Selfish than the Rest?
A substantial body of research suggests that economists are less generous than other professionals and that economics students are less generous than other students. We address this question using administrative data on donations to social programs by students at the University of Washington. Our data set allows us to track student donations and economics training over time in order to distinguish selection effects from indoctrination effects. We find that economics majors are less likely to donate than other students and that there is an indoctrination effect for non-majors but not for majors. Women majors and non-majors are less likely to contribute than comparable men.altruism, public goods
Tax Shift: How to Help the Economy, Improve the Environment, and Get the Tax Man off Our Backs
In the other Washington, there's always talk of scrapping the federal tax code. It's no mystery why. The Internal Revenue Code runs to 7.5 million words and occupies, with regulations, one and one-half feet of shelf space. But complexity is not the worst fault of taxdom. The biggest and least-discussed problem is this: We tax the wrong things. Mostly, we tax things we want more of, such as paychecks and enterprise, not things we want less of, such as pollution and resource depletion. Naturally, we get less money and more messes. Doing the opposite would yield double dividends: cleaner air and flusher bank accounts. "Tax Shift" is a blueprint for a revolt that would get taxes off our backs and onto our side
An Aggregate Measure for Benefit-Cost Analysis
The Kaldor-Hicks (KH) criterion has long been the standard for benefit-cost analysis, but it has also been widely criticized for ignoring equity and, arguably, moral sentiments in general. We suggest replacing KH with an aggregate measure called KHM, where the M stands for moral sentiments. KHM simply adds to the traditional KH criterion the requirement that any good for which there is a willingness to pay or accept count as an economic good. This suggested expansion of KH, however, must confront objections to counting moral sentiments in general and non-paternalistic altruism in particular. We show that these concerns are unwarranted and suggest that the KHM criterion is superior to KH because it provides better information.
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Economic Impacts Of Climate Change On Forest Resources in Oregon A Preliminary Analysis
14 p.This report offers a preliminary assessment of the economic effects of global climate change on Oregon’s forest resources during the first half of the twenty-first century
Comment on Nordhaus: Carbon Tax Calculations
William Nordhaus confuses the impact of a tax on carbon and a tax on carbon dioxide, according to Yoram Bauman.
Why are economics students more selfish than the rest? 1
1 We thank Susana Angkico of the UW registrar’s office for help with the data set, participants in a seminar at University of California – Davis for helpful comments, and Wolfram Latsch for helpful conversations. A substantial body of research suggests that economists are less generous than other professionals and that economics students are less generous than other students. We address this question using administrative data on donations to social programs by students at the University of Washington. Our data set allows us to track student donations and economics training over time in order to distinguish selection effects from indoctrination effects. We find that economics majors are less likely to donate than other students and that there is an indoctrination effect for non-majors but not for majors. Women majors and non-majors are less likely to contribute than comparable men. 2 I
The cartoon introduction to economics : volume two : macroeconomics
Library also has The Cartoon Introduction to Economics : Volume One : Microeconomics227 p. ; 27 cm