The Design of a Patient Transportation Robot's Lifting Arms Considering Comfort and Safety without the Presence of a Sheet

A transportation robot's lifting arms have an effect on the comfort and safety of patients. Improved arms have been designed through dynamic and static analyses to increase safety if a sheet not present on the lifting arms. To design the lifting arms, experimentation is very helpful, however, it is difficult and dangerous to experiment on patients; therefore, a simple human model was made and used for the dynamic analysis. Through the dynamic analysis results, a safe width and comfortable location for the lifting arms were determined. The thickness was then determined by static analysis and optimum design. In addition, tests have been conducted to confirm comfort and safety by deploying the designed lifting arms onto a transportation robot

Continuous Facial Motion Deblurring

We introduce a novel framework for continuous facial motion deblurring that restores the continuous sharp moment latent in a single motion-blurred face image via a moment control factor. Although a motion-blurred image is the accumulated signal of continuous sharp moments during the exposure time, most existing single image deblurring approaches aim to restore a fixed number of frames using multiple networks and training stages. To address this problem, we propose a continuous facial motion deblurring network based on GAN (CFMD-GAN), which is a novel framework for restoring the continuous moment latent in a single motion-blurred face image with a single network and a single training stage. To stabilize the network training, we train the generator to restore continuous moments in the order determined by our facial motion-based reordering process (FMR) utilizing domain-specific knowledge of the face. Moreover, we propose an auxiliary regressor that helps our generator produce more accurate images by estimating continuous sharp moments. Furthermore, we introduce a control-adaptive (ContAda) block that performs spatially deformable convolution and channel-wise attention as a function of the control factor. Extensive experiments on the 300VW datasets demonstrate that the proposed framework generates a various number of continuous output frames by varying the moment control factor. Compared with the recent single-to-single image deblurring networks trained with the same 300VW training set, the proposed method show the superior performance in restoring the central sharp frame in terms of perceptual metrics, including LPIPS, FID and Arcface identity distance. The proposed method outperforms the existing single-to-video deblurring method for both qualitative and quantitative comparisons

AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS

While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials. To explore the possibility that concurrent blockade of free radicals and PGE2-mediated inflammation might constitute a safe and effective therapeutic approach to certain neurodegenerative diseases, we have developed 2-hydroxy-5-[2-(4-trifluoromethylphenyl)-ethylaminobezoic acid (AAD-2004) as a derivative of aspirin. AAD-2004 completely removed free radicals at 50 nM as a potent spin trapping molecule and inhibited microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 230 nM. Oral administration of AAD-2004 blocked free radical formation, PGE2 formation, and microglial activation in the spinal motor neurons of SOD1G93A mice. As a consequence, AAD-2004 reduced autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span. In these assays, AAD-2004 was superior to ibuprofen or riluzole. Gastric bleeding was not induced by AAD-2004 even at a dose 400-fold higher than that required to obtain maximal therapeutic efficacy in SOD1G93A mice. Targeting both mPGES-1 and free radicals may be a promising approach to reduce neurodegeneration in ALS and possibly other neurodegenerative diseases

Direction of Arrival Estimation Algorithm: Direction Lock Loop

In this paper, a new direction of arrival (DOA) estimation algorithm, direction lock loop (DiLL), is proposed. It has a similar concept to the delay lock loop (DLL) that is used for synchronization. It estimates the DOA of a signal by iterations, and can track the DOA of a moving source. The DiLL scheme is found to track better than the DOA estimation scheme based on the PASTd, and its performance is less sensitive to the DOA of a signal than that of the DOA estimation scheme based on the PASTd. The DOA estimation accuracy and the tracking capability are demonstrated by analysis and computer simulations

Clinical characteristics of 2009 pandemic influenza A (H1N1) infection in children and the performance of rapid antigen test

PurposeIn autumn 2009, the swine-origin influenza A (H1N1) virus spread throughout South Korea. The aims of this study were to determine the clinical characteristics of children infected by the 2009 H1N1 influenza A virus, and to compare the rapid antigen and real-time polymerase chain reaction (PCR) tests.MethodsWe conducted a retrospective review of patients ≥18 years of age who presented to Soonchunhyang University Hospital in Seoul with respiratory symptoms, including fever, between September 2009 and January 2010. A real-time PCR test was used to definitively diagnose 2009 H1N1 influenza A infection. Medical records of confirmed cases were reviewed for sex, age, and the time of infection. The decision to perform rapid antigen testing was not influenced by clinical conditions, but by individual factors such as economic conditions. Its sensitivity and specificity were evaluated compared to real-time PCR test results.ResultsIn total, 934 patients tested positive for H1N1 by real-time PCR. The highest number of patients (48.9%) was diagnosed in November. Most patients (48.2%) were aged between 6 and 10 years. Compared with the H1N1 real-time PCR test results, the rapid antigen test showed 22% sensitivity and 83% specificity. Seventy-eight patients were hospitalized for H1N1 influenza A virus infection, and fever was the most common symptom (97.4%).ConclusionFor diagnosis of 2009 H1N1 influenza A virus infection, the rapid antigen test was inferior to the real-time PCR test in both sensitivity and specificity. This outcome suggests that the rapid antigen test is inappropriate for screening

Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery

This study attempted to prepare polyethylene-glycol modified (PEGylated) and folate-PEGylated liposomes containing paclitaxel (Ptx) in order to reduce the toxicity and improve the bioavailability and biocompatibility by targeting drugs to the lymphatics using cancer cell specific ligand folate to prevent metastasis via the lymphatic system. Liposomes were prepared by lipid film hydration method using PEG and folate-PEG as surface modifiers. The mean particle size and encapsulation efficiency of liposomes were 114±6.81 nm and 81±2.3% for PEGylated liposome and 122±4.87 nm and 88±2.0% for folate-PEGylated liposome, respectively. According to stability test, it could be confirmed that PEGylated and folate-PEGylated liposomes were stable for at least 5 days. After intravenous administration of the PEGylated and folate-PEGylated liposomes to rats, the CLt (total clearance) and t1/2 (half-life) were significantly different (P<0.05) compared with those of PADEXOL Inj. In targeting efficiency, calculated as the concentration ratio of Ptx in lymph nodes and plasma, there was significant increase in targeting efficiency at lymph nodes (P<0.05). From these results, we could conclude that the prepared Ptx-containing PEGylated and folate-PEGylated liposomes are good candidates for the targeted delivery of the drug to lymphatic system

The Influence of Tibial Positioning on the Diagnostic Accuracy of Combined Posterior Cruciate Ligament and Posterolateral Rotatory Instability of the Knee

Background: To determine if tibial positioning affects the external rotation of the tibia in a dial test for posterolateral rotatory instability combined with posterior cruciate ligament (PCL) injuries. Methods: Between April 2007 and October 2007, 16 patients with a PCL tear and posterolateral rotatory instability were diagnosed using a dial test. The thigh-foot angle was measured at both 30 ° and 90 ° of knee fl exion with an external rotation stress applied to the tibia in 2 different positions (reduction and posterior subluxation). The measurements were performed twice by 2 orthopedic surgeons. Results: In posterior subluxation, the mean side-to-side difference in the thigh-foot angle was 11.56 ± 3.01 ° at 30 ° of knee fl exion and 11.88 ± 4.03 ° at 90 ° of knee flexion. In the sequential dial test performed with the tibia reduced, the mean side-to-side difference was 15.94 ± 4.17 ° (p &lt; 0.05) at 30 ° of knee fl exion and 16.88 ± 4.42 ° (p = 0.001) at 90 ° of knee fl exion. The mean tibial external rotation was 5.31 ± 2.86 ° and 6.87 ± 3.59 ° higher in the reduced position than in the posterior subluxation at both 30° and 90 ° of knee fl exion. Conclusions: In the dial test, reducing the tibia with an anterior force increases the ability of an examiner to detect posterolateral rotary instability of the knee combined with PCL injuries

Direction-of-Arrival Tracking Scheme for DS/CDMA Systems: Direction Lock Loop

In this paper, a new direction-of-arrival (DOA) tracking algorithm, direction lock loop (DiLL), is proposed for wireless direct-sequence code-division multiple-access systems. It has a similar concept to the delay lock loop that is used for timing synchronization. It may track the DOA of sources by iterations. Its computational requirements are + O( ) for coherent DiLL and 2 + O( ) for noncoherent DiLL, where is the number of antenna elements and is the number of signal sources, which is less than that of the projection approximation subspace tracking with deflation algorithm [5]. The DOA tracking accuracy is demonstrated by analysis and computer simulations