The influence of abiotic factors on the presence of European corn borer (Ostrinia nubilalis Hübner)

Istraživanja su provedena tijekom trogodišnjeg razdoblja (2012. – 2014.) u poljskim uvjetima s prirodnom zarazom kukuruznoga moljca, na Poljoprivrednom institutu u Osijeku. Cilj istraživanja bio je utvrditi utjecaj različitih varijanti navodnjavanja i gnojidbe i utjecaj genotipa na pojavu i oštećenost biljki od kukuruznoga moljca te povezanost ishrane gusjenica s koncentracijom dušika, silicija i C/N odnosa u listu kukuruza. Na kraju svake vegetacijske sezone zabilježena je masa klipa (g), dužina oštećenja stabljike (cm), oštećenje drške klipa (cm), broj gusjenica u stabljici kukuruza, broj gusjenica u dršci klipa, te ukupan broj gusjenica po biljci. U 2014. godini kada su bile niže temperature, a veća količina oborina utvrđen je značajno niži napad u odnosu na druge dvije ispitivane godine. Uz pomoć feromonskih mamaca utvrđena je dominantnost Z-tipa kukuruznoga moljca na području istočne Slavonije. Povišenom razinom sadržaja vode u tlu utvrdilo se manje oštećenje biljke, a povećanjem razine gnojidbe utvrđeno je veće oštećenje na biljkama kao posljedica ishrane gusjenica. Utvrđena je različita otpornost hibrida u odnosu na oštećenje od gusjenica te se hibrid C4 izdvojio kao najotporniji, dok je C1 bio najosjetljiviji. Koncentracija dušika i silicija u listu kukuruza u negativnoj su korelaciji kao i koncentracija dušika i C/N odnos. Otpornost kod hibrida nije isključivo ovisila o koncentracijama dušika i silicija iako se pokazalo kod većine hibrida pri povećanoj koncentraciji dušika veće oštećenje, a kod povećane koncentracije silicija utvrđeno je manje oštećenje.Field experiments with natural population of ECB were conducted in three vegetation seasons (2012-2014) at the Agricultural Institute in Osijek. The aim of this study was to determine the effect of different levels of irrigation and nitrogen fertilization and various genotypes on the occurrence and damage of maize plants from European corn borer larvae and relationship with nitrogen and silicon content as well as C/N ratio. At the end of each growing season were determined ear weight (g), tunnel length (stalk) (cm), ear shank damage (cm), the number of larvae in corn stalk, number of larvae in the ear shank, and total number of larvae in plant. In 2014, with lower temperatures and higher amount of precipitate compared to the previous years, a significantly lower ECB attack was determined. Dominance of Z-type European corn borer on pheromone traps in the area of eastern Slavonia was determined. Increasing the level of soil water content damage from larvae was reduced and increasing the level of nitrogen fertilization feeding activity was increased. We have confirmed different hybrid resistance in regards to damage from larvae, so C4 genotype was the most resistant while C1 was the most susceptible. Concentration of nitrogen and silicon in a maize leaf were in negative correlation as well as nitrogen concentration and C/N ratio. Hybrid resistance didn't entirely depend on nitrogen and silicon concentrations, even though there was greater damage at most hybrids with higher concentration of nitrogen, while damage was reduced with higher concentration of silicon

Rate of exposure of a sentinel species, invasive American mink (Neovison vison) in Scotland, to anticoagulant rodenticides

Anticoagulant rodenticides (ARs) are highly toxic compounds that are exclusively used for the control of rodent pests. Despite their defined use, they are nonetheless found in a large number of non-target species indicating widespread penetration of wildlife. Attempts to quantify the scale of problem are complicated by non-random sampling of individuals tested for AR contamination. The American mink (Neovison vison) is a wide ranging, non-native, generalist predator that is subject to wide scale control efforts in the UK. Exposure to eight ARs was determined in 99 mink trapped in NE Scotland, most of which were of known age. A high percentage (79%) of the animals had detectable residues of at least one AR, and more than 50% of the positive animals had two or more ARs. The most frequently detected compound was bromadiolone (75% of all animals tested), followed by difenacoum (53% of all mink), coumatetralyl (22%) and brodifacoum (9%). The probability of mink exposure to ARs increased by 4.5% per month of life, and was 1.7 times higher for mink caught in areas with a high, as opposed to a low, density of farms. The number of AR compounds acquired also increased with age and with farm density. No evidence was found for sexual differences in the concentration and number of ARs. The wide niche and dietary overlap of mink with several native carnivore species, and the fact that American mink are culled for conservation throughout Europe, suggest that this species may act as a sentinel species, and the application of these data to other native carnivores is discussed

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Correction: Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

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The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

A coalescent-based estimator of genetic drift, and acoustic divergence in the Pteronotus parnellii species complex

Dávalos, Liliana M., Lancaster, Winston C., Núñez-Novas, Miguel S., León, Yolanda M., Lei, Bonnie, Flanders, Jon, Russell, Amy L. (2018): A coalescent-based estimator of genetic drift, and acoustic divergence in the Pteronotus parnellii species complex. Heredity 122 (4): 417-427, DOI: 10.1038/s41437-018-0129-3, URL: http://dx.doi.org/10.1038/s41437-018-0129-