The Tale of the Tokugawa Artifacts: Japanese Funerary Lanterns at the Penn Museum

That previously stood at the back of the quiet inner courtyard of the Penn Museum waited many years for its significance to be rediscovered. It is one of the Tokugawa lanterns that long illuminated the shogunate family’s grand mausoleums during the Edo period (1603–1868 CE) in the Zōjōji temple in Tokyo, Japan. Photographs taken around 1930 show the lanterns flanking the Museum entrance in the Stoner Courtyard. The prominent placement of these objects suggests that, in those days, the Museum acknowledged the significance of the lanterns. One of the lanterns was subsequently moved to Museum storage after suffering damage from an act of vandalism in the 1950s or 1960s. Although it is not clear exactly when the lanterns left Japan and arrived in the United States, Stephen Lang, Lyons Keeper in the Asian Section at the Museum, has determined that the lanterns came into the Museum collection as a loan in 1919 from Mrs. Richard Waln Meirs (Anne Walker Weightman Meirs Rush, 1871–1958). They may have been sent from Japan by Mrs. Meirs’ uncle, Robert Jarvis Cochran Walker in the late 1880s to be displayed at Meirs’ Ravenhill Mansion. [excerpt

FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast

免疫抑制剤の新しい作用メカニズムの解明 --FKBP12は真菌のイソロイシン生合成酵素を抑制する--. 京都大学プレスリリース. 2022-12-13.FK506-binding protein with a molecular weight of 12 kDa (FKBP12) is a receptor of the immunosuppressive drugs, FK506 and rapamycin. The physiological functions of FKBP12 remain ambiguous because of its nonessentiality and multifunctionality. Here, we show that FKBP12 promotes the utilization of serine as a nitrogen source and regulates the isoleucine biosynthetic pathway in fission yeast. In screening for small molecules that inhibit serine assimilation, we found that the growth of fission yeast cells in medium supplemented with serine as the sole nitrogen source, but not in glutamate-supplemented medium, was suppressed by FKBP12 inhibitors. Knockout of FKBP12 phenocopied the action of these compounds in serine-supplemented medium. Metabolome analyses and genetic screens identified the threonine deaminase, Tda1, to be regulated downstream of FKBP12. Genetic and biochemical analyses unveiled the negative regulation of Tda1 by FKBP12. Our findings reveal new roles of FKBP12 in amino acid biosynthesis and nitrogen metabolism homeostasis

ヒト白血病K562細胞でクロトリマゾールにより誘発される細胞死に対するマイクロモル濃度の亜鉛の影響

Our recent study showed that the simultaneous application of clotrimazole with CdCI2 or PbCI2 exerted potent cytotoxic action in rat thymocytes although respective agents were ineffective. It was also the case of ZnCl2 and clotrimazole in preliminary study using rat thymocytes. Since clotrimazole is supposed to be a candidate for anticancer drug, we examined the effects of clotrimazole, ZnCI2, and their combination on human leukemia K562 cells. The combination of clotrimazole and ZnCl2 exerted potent cytotoxic effects on the growth and lethality of K562 cells by presumably modifying the process of cell death. The result suggests the possibility that endogenous Zn2+ may modify the action of clotrimazole