Implication of Climate Change Induced Variation in Wind Extremes on Wind Farm in Mountainous Area of Central China—A Case Study of Hengshan

AbstractWind load is critical to the safety of wind turbines. Wind turbines are designed according to the referrence wind speed of 50-year recurrence interval. The climate change induced variation in extremes of wind could impact safety of wind turbines. Meteorological data from Hengshan weather station in central China is investigated. The wind data of 1973–1992 and 1992–2011 are utilized to estimate the extreme wind of 50-year recurrence interval using method of independent storm and generalized pareto distribution model. It is uncovered that although extreme wind of 50-year recurrence interval escalate a little during the two time spans, it will not affect the safety of wind turbines over there notably

Research on the Reform and Innovation of Financial Management in Higher Universities under the Double-Class Construction Background: A Case from China University of Geosciences (Beijing)

Under the double-class construction background, the financial management has gradually become one of the most important contents of higher universities. It is the basement of all economic activities in colleges and universities, determines the basic direction of financial management, and is also subject to the overall development goal of colleges and universities. With the transition of the economic system of colleges and universities, the reform of the financial system and the continuous change of the financial management environment, the financial management is facing the challenge of informatization, knowledge and networking, which require colleges and universities to reform the original financial management system and innovate the concept, content and mode of financial management to adapt to the changes of colleges and universities in the new stage. Taking China University of Geosciences (Beijing) as an example, this paper analyses the necessity of financial management reform and innovation, and puts forward several suggestions for reform and innovation of financial management, so as to continuously improve the financial management level of higher universities under the double-class construction background

Direct-Write Micro/Nano-Structure For Flexible Electronic Manufacturing

This article focuses on optimizing the electrospinning parameters, and developing a new method of Direct-Write (DW) micro/nano-structure based on Near-Field Electrospinning (NFES) for flexible electronic manufacturing. NFES is a new way to realize controllable electrospinning and precision-positioning of nanofiber, by which nano-structure with diameter from 50nm to 500nm can be fabricated orderly and accurately. A tungsten electrode with tip diameter of 25 mu m is used to DW nano-structure, with the minimum bias voltage 600V, minimum electrode to collector distance 500 mu m. A microstructure DW system is designed, by which micro-structure with diameter of several micrometers can be drawn. In this work a needle tube of 232 mu m inside diameter is used as spinneret, electrode to collector distance is various from 2mm to 10mm, and the collector moving speed ranges from 0.07m/s to 7m/s. The DW process and character of micro-structure such as line width, smoothness and thickness can be controlled by optimizing the electrospinng parameters. The DW micro/nano-structure is continuous and smooth, which can be drawn on expected site and in expected direction with accurate dimension. The new method based on NEFS with the advantage of narrower line width and smoother structure than traditional flexible electronic manufacturing technologies, which is more suitable for the development of flexible electronic manufacturing

Investigations on ElectroHydroDynamical Drop-On-Demand Inkjet Printing

The effects of electrohydrodynamical(EHD) drop-on-demand inkjet variables on the droplet diameter are presented in this paper. The EHD printer uses a high pulsed voltage to generate strong electric field in the vicinity of the apex of the dome-shaped liquid meniscus and thus micro-jetting ejection of droplet comes forth. And the liquid shaping processes are revealed through CCD. The droplets with 50 mu m diameter were formed on the silicon collector. We have evaluated systematically the effects of EHD inkjet printing design variables such as the voltage, the frequency, the solution concentration, the voltage duty cycle and the contact angle on the droplet diameters. The experiment results show the droplet diameters get larger with the voltage, the solution concentration and the voltage duty cycle increasing respectively. And when the frequency, the contact angle increases respectively, the droplet diameters get smaller

Flavonoids from Lycium barbarum leaves attenuate obesity through modulating glycolipid levels, oxidative stress, and gut bacterial composition in high-fat diet-fed mice

Traditional herbal therapy made from Lycium barbarum leaves has been said to be effective in treating metabolic diseases, while its exact processes are yet unknown. Natural flavonoids are considered as a secure and reliable method for treating obesity. We thus made an effort to investigate the processes by which flavonoids from L. barbarum leaves (LBLF) reduce obesity. To assess the effectiveness of the intervention following intragastric injection of various dosages of LBLF (50, 100, and 200 mg/kg⋅bw), obese model mice developed via a high-fat diet were utilized. Treatment for LBLF may decrease body weight gain, Lee’s index, serum lipids levels, oxidative stress levels, and hepatic lipids levels. It may also enhance fecal lipids excretion and improve glucose tolerance. Additionally, LBLF therapy significantly restored gut dysfunction brought on by a high-fat diet by boosting gut bacterial diversities and altering the composition of the gut bacterial community by elevating probiotics and reducing harmful bacteria

Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis

Transforming growth factor β1 (TGF-β1) has a neuroprotective function in traumatic brain injury (TBI) through its anti-inflammatory and immunomodulatory properties. However, the precise mechanisms underlying the neuroprotective actions of TGF-β1 on the cortex require further investigation. In this study, we were aimed to investigate the regulatory function of TGF-β1 on neuronal autophagy and apoptosis using an in vitro primary cortical neuron trauma-injury model. LDH activity was assayed to measure cell viability, and intracellular [Ca2+] was measured using Fluo-4-AM in an in vitro primary cortical neuron trauma-injury model. RNA-sequencing (RNAseq), immunofluorescent staining, transmission electron microscopy (TEM), western blot and CTSD activity detection were employed. We observed significant enrichment of DEGs related to autophagy, apoptosis, and the lysosome pathway in trauma-injured cortical neurons. TEM confirmed the presence of autophagosomes as well as autophagolysosomes. Western blot revealed upregulation of autophagy-related protein light chain 3 (LC3-II/LC3-I), sequestosome 1 (SQSTM1/p62), along with apoptosis-related protein cleaved-caspase 3 in trauma-injured primary cortical neurons. Furthermore, trauma-injured cortical neurons showed an upregulation of lysosomal marker protein (LAMP1) and lysosomal enzyme mature cathepsin D (mCTSD), but a decrease in the activity of CTSD enzyme. These results indicated that apoptosis was up-regulated in trauma- injured cortical neurons at 24 h, accompanied by lysosomal dysfunction and impaired autophagic flux. Notably, TGF-β1 significantly reversed these changes. Our results suggested that TGF-β1 exerted neuroprotective effects on trauma- injured cortical neurons by reducing lysosomal dysfunction, decreasing the accumulation of autophagosomes and autophagolysosomes, and enhancing autophagic flux

Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis

Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is a pleiotropic cytokine that primarily activates the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, and other physiological processes such as cell proliferation, inflammatory response, immune response, and hematopoiesis through its receptor complex. In this review, we first describe the characteristics of OSM and its receptor, and the biological functions of OSM signaling. Subsequently, we discuss the possible roles of OSM in the development of RA from clinical and basic research perspectives. Finally, we summarize the progress of clinical studies targeting OSM for the treatment of RA. This review provides researchers with a systematic understanding of the role of OSM signaling in RA, which can guide the development of drugs targeting OSM for the treatment of RA

Potential of Core-Collapse Supernova Neutrino Detection at JUNO

JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve

Detection of the Diffuse Supernova Neutrino Background with JUNO

As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO

Real-time Monitoring for the Next Core-Collapse Supernova in JUNO

Core-collapse supernova (CCSN) is one of the most energetic astrophysical events in the Universe. The early and prompt detection of neutrinos before (pre-SN) and during the SN burst is a unique opportunity to realize the multi-messenger observation of the CCSN events. In this work, we describe the monitoring concept and present the sensitivity of the system to the pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is a 20 kton liquid scintillator detector under construction in South China. The real-time monitoring system is designed with both the prompt monitors on the electronic board and online monitors at the data acquisition stage, in order to ensure both the alert speed and alert coverage of progenitor stars. By assuming a false alert rate of 1 per year, this monitoring system can be sensitive to the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos up to about 370 (360) kpc for a progenitor mass of 30$M_{\odot}$ for the case of normal (inverted) mass ordering. The pointing ability of the CCSN is evaluated by using the accumulated event anisotropy of the inverse beta decay interactions from pre-SN or SN neutrinos, which, along with the early alert, can play important roles for the followup multi-messenger observations of the next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure