U(1)-decoupling, KK and BCJ relations in N=4\mathcal{N}=4 SYM

We proved the color reflection relation, U(1)-decoupling, Kleiss-Kuijf and Bern-Carrasco-Johansson relation for color-ordered $\mathcal{N}=4$ Super Yang-Mills theory using $\mathcal{N}=4$ SYM version BCFW recursion relation, which depends only on the general properties of super-amplitudes. This verified the conjectured matter fields BCJ relation. We also show that color reflection relation and U(1)-decoupling relation are special cases of KK relation, if we consider the KK relation as a general relation, then the former two relations come out naturally as the special cases.Comment: 17 page

Assessment of Heavy Metal Content and Consumption Risks At Selected Paddy Field in Malaysia: A Review

As the Malaysian population grows, there is a high demand for rice, the main staple food in this region. This has caused the overuse of agrochemicals that contain heavy metals and the utilization of contaminated groundwater to increase paddy yield, posing a risk to humans. This study reviewed the accumulated heavy metals in paddy fields of Malaysia's Selangor, Kedah and Sabah states and further calculated the consumption risks of rice grains from the selected areas. The study revealed that paddy soil in Ranau Valley (Sabah), Kota Marudu (Sabah) and Tanjung Karang (Selangor) showed presences of Cu and Cd in high concentration, respectively, creating higher potential to be uptake by paddy roots. These findings also revealed that Ranau Valley (Sabah) paddy grains contained high Cu and Cd concentrations, while Sabak Bernam (Selangor) contained high Pb concentrations. Further, a higher Cd concentration was reported from the Ranau Valley (Sabah), while the higher Pb concentrations were reported from the samples collected from Sabak Bernam (Selangor), Tanjung Karang (Selangor) and Kubang Pasu (Kedah). Based on the health risk indices calculation in this study, carcinogenic and non-carcinogenic health risks in all study areas except in Kubang Pasu (Kedah) and Langkawi (Kedah) are likely to occur due to Cu mining activities, ultrabasic soil contamination, utilization of contaminated groundwater and rock phosphate fertilizer and vehicular emission. Regular assessment of heavy metal content and consumption risks of paddy is essential to ensure the paddy field is free from contamination and will help protect the ecosystem and human health

Gauge Amplitude Identities by On-shell Recursion Relation in S-matrix Program

Using only the Britto-Cachazo-Feng-Witten(BCFW) on-shell recursion relation we prove color-order reversed relation, $U(1)$-decoupling relation, Kleiss-Kuijf(KK) relation and Bern-Carrasco-Johansson(BCJ) relation for color-ordered gauge amplitude in the framework of S-matrix program without relying on Lagrangian description. Our derivation is the first pure field theory proof of the new discovered BCJ identity, which substantially reduces the color ordered basis from $(n-2)!$ to $(n-3)!$. Our proof gives also its physical interpretation as the mysterious bonus relation with ${1\over z^2}$ behavior under suitable on-shell deformation for no adjacent pair.Comment: 4 Pages. No Figures. Rewriting of Introductio

Tree amplitudes of noncommutative U(N) Yang-Mills Theory

Following the spirit of S-matrix program, we proposed a modified Britto-Cachazo-Feng-Witten recursion relation for tree amplitudes of noncommutative U(N) Yang-Mills theory. Starting from three-point amplitudes, one can use this modified BCFW recursion relation to compute or analyze color-ordered tree amplitudes without relying on any detail information of noncommutative Yang-Mills theory. After clarifying the color structure of noncommutative tree amplitudes, we wrote down the noncommutative analogies of U(1)-decoupling, Kleiss-Kuijf and Bern-Carrasco-Johansson relations for color-ordered tree amplitudes, and proved them using the modified BCFW recursion relation.Comment: 24 pages, 3 figures. v2 References added. v3 some typos correcte

COMPARISON OF EFFICACY AND SAFETY OF NEWER DRUGS APPROVED FOR THE TREATMENT OF MIGRAINE DISORDER: A REVIEW

Migraine is a recurrent throbbing or pulsing headache with moderate to severe pain intensity. The pain is often one side of the head with nausea and weakness symptoms. Around 12 percent of Americans, 9 percent of Asians experiences migraine and the prevalence is highest among South Koreans (22.3%). The outcome of chronic migraine treatment can be quite disheartening, causing patients to feel out of options who have tried multiple treatments with no results. Poor efficacy, tolerability and safety of migraine preventive therapy in clinical practice lead to poor compliance and failure of therapy. The mean change in number or frequency of headache is considered as the outcome measure of migraine prevention therapy. Upon comparing all migraine prevention therapy, the Fremanezumab, Eptinezumab, Galcanezumab and Erenumab were considered as the front runner in controlling the severity and frequency of migraine. Among these drugs, Erenumab was most effective in controlling the frequency of migraine episodes as it produces more than 50 percent reduction in the mean number of monthly migraine days (MMD) over week 9-week 12. In addition to drug therapy, adequate rest, balanced diet, yoga and meditation will help patients to get rid of migraine severity. A multi-dimensional approach is essential for better control over migraine symptoms

Note on New KLT relations

In this short note, we present two results about KLT relations discussed in recent several papers. Our first result is the re-derivation of Mason-Skinner MHV amplitude by applying the S_{n-3} permutation symmetric KLT relations directly to MHV amplitude. Our second result is the equivalence proof of the newly discovered S_{n-2} permutation symmetric KLT relations and the well-known S_{n-3} permutation symmetric KLT relations. Although both formulas have been shown to be correct by BCFW recursion relations, our result is the first direct check using the regularized definition of the new formula.Comment: 15 Pages; v2: minor correction

A common variant near TGFBR3 is associated with primary open angle glaucoma

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10−33), we observed one SNP showing significant association to POAG (CDC7–TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10−8). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P < 5 × 10-8) three novel loci associated with HDL-C near CD163-APOBEC1 (P = 7.4 × 10-9), NCOA2 (P = 1.6 × 10-8), and NID2-PTGDR (P = 4.2 × 10-8), and one novel locus associated with TG near WDR11-FGFR2 (P = 2.7 × 10-10). Conditional analyses identified a second signal near CD163-APOBEC1. We then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis. This analysis identified (log10Bayes Factor ≥6.1) eight additional novel lipid loci. Among the twelve total loci identified, the index variants at eight loci have demonstrated at least nominal significance with other metabolic traits in prior studies, and two loci exhibited coincident eQTLs (P < 1 × 10-5) in subcutaneous adipose tissue for BPTF and PDGFC. Taken together, these analyses identified multiple novel lipid loci, providing new potential therapeutic targets

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia : The CREAM Consortium

Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7-15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N = 10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P = 6.6E-08) and 2.3% (P = 6.9E-21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry samples (combined N = 5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in ZMAT4; P = 6.3E-04).Peer reviewe

Integrins as therapeutic targets: lessons and opportunities.

The integrins are a large family of cell adhesion molecules that are essential for the regulation of cell growth and function. The identification of key roles for integrins in a diverse range of diseases, including cancer, infection, thrombosis and autoimmune disorders, has revealed their substantial potential as therapeutic targets. However, so far, pharmacological inhibitors for only three integrins have received marketing approval. This article discusses the structure and function of integrins, their roles in disease and the chequered history of the approved integrin antagonists. Recent advances in the understanding of integrin function, ligand interaction and signalling pathways suggest novel strategies for inhibiting integrin function that could help harness their full potential as therapeutic targets