Influence of Spirocarbone and Derivates of Pyrimidineones on Separate Components of the Oxygen – Transport of blood in vitrol

Rechytskyi, О. Influence of Spirocarbone and Derivates of Pyrimidineones on Separate Components of the Oxygen – Transport of blood in vitrol VII Parnas Conference on Biochemistry and Molecular biology / L. Starykovych, K. Dudok, M. Starykovych, O. Rechytskyi, B. Yeresko, N. Sybirna // Yalta, Crimea, Ukraine, 3-7 October, 2009 The Ukrainian Biochemical Journal. – 2009. – V. 81. – № 4. – Р. 258

Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells

Influence of spirocarbone and derivates of pyrrolopyrimidinediones (1,6-dimethyl-4-phenyl-1,2,3,4,5,7-hexahydropyrolo-[3,4-d]-pyrimidindione-2,5(1Н), and 1,6-dimethyl-4-(2-threefluoromethylphenyl)-1,2,3,4,5,7-hexahydropyrrolo-[3,4-d]-pyrimidinedione-2,5(1Н) on the leukemia cells of L1210 and CEM-T4 lines of mouse and human, res­pectively was studied. Cytotoxic effect of spirocarbone towards L1210 cells accompa­nied by apoptotic fragmen­tation of nuclear DNA

ЕНЕРГОЕФЕКТИВНИЙ ПЕРЕТВОРЮВАЛЬНИЙ АГРЕГАТ З ФУНКЦІЯМИ ФІЛЬТРАЦІЇ ГАРМОНІК ВИХІДНОЇ НАПРУГИ ТЯГОВОЇ ПІДСТАНЦІЇ СИСТЕМИ ЕЛЕКТРОПОСТАЧАННЯ ПОСТІЙНОГО СТРУМУ НАПРУГОЮ 3КВ

The combined system of active filtration of target voltage of the rectifier using an added voltage converter as an in-series link and a high-frequency current inverter as parallel one is offered. Its application allows reducing weight of a choke of the passive filter.Предлагается комбинированная система активной фильтрации выходного напряжения выпрямителя, использующая в качестве последовательного звена вольтодобавочный преобразователь, а в качестве параллельного - высокочастотный инвертор тока. Использование комбинированной системы позволяет сократить массу дросселя пассивного фильтра.Пропонується комбінована система активної фільтрації вихідної напруги випрямляча, яка використовує в якості послідовної ланки вольтодобавочний перетворювач, а паралельної – високочастотний інвертор струму. Використання комбінованої системи дозволяє зменшити масу дроселя пасивного фільтру

Influence of spirocarbone and derivates of pyrrolopyrimidinedions on phisical and chemical properties of the hemoglobin ligand forms of blood in vitro

The effect of heterocyclic substance spirocarbon and pyrrolopyrimidinedione derivatives was studied on the hemoglobin ligand forms dynamics (RHb, HbO2, HbCO, SHb, MetHb), its basic stability, methemoglobin peroxidase activity and spectrophotometric characteristics of CNMetHb-Coomassi G-250 in the healthy donors’ blood. It was shown that spirocarbon causes a slight HbO2 decrease. In the experiments with pyrrolopyrimidindion derivatives the everage HbO2 values are in the range of control. There was carried out an analysis of HbO2, MetHb, CNMetHb electron spectra and the electron spectra of the complexes CNMetHb-Coomassi G-250. It was testified that spirocarbon causes a certain increase of basic stable hemoglobin and decrease of peroxydase activity. The pyrrolopyrimidinedione derivatives result in increasing of methemoglobin peroxydase activity in the tested samples

Development of the GRAiNITA prototype with ZnWO<inf>4</inf> and BGO crystal grains

International audienceWe will present the development of two medium-size prototypes of GRAiNITA, a next-generation shashlik calorimeter, based on the use of ZnWO4and BGO crystal grains, respectively, soaked in a high-density and high-refractive index liquid. As in the LiquidO detection technique[1], due to the presence of the grains, the scintillation light remains stochastically confined in the area of production; for this reason, it can be collected and transferred towards the photodetectors by the use of wavelength shifting fibers evenly distributed in the detection volume, similarly as in a conventional shashlik calorimeter.GRAiNITA represents a very appealing electromagnetic calorimeter candidate for high energy physics experiments for future electron-positron colliders. Indeed, due to the extreme fine sampling, GRAiNITA has the potential to reach a photon energy resolution of R~2%/sqrt(E) [2], thus increasing the precision of flavor physics with rare decays to photons or neutral pions. In this communication, we will present the outcomes of the study that led us to the choice of the best suited fibers for ZnWO4and BGO, respectively, and we will present the effect observed on the light propagation, when adding isopropanol in the detection volume (as a first approximation of future liquids), to fill the space between the crystal grains. Finally, we will discuss the development and characterization of the prototypes, presenting either the mechanical and the electronic design

THE ENERGY EFFICIENT CONVERTER UNIT WITH FILTERING OF THE HARMONICS OF THE OUTPUT VOLTAGE TRACTION POWER SUPPLY SYSTEM OF DC WITH VOLTAGE OF 3 KV

The combined system of active filtration of target voltage of the rectifier using an added voltage converter as an in-series link and a high-frequency current inverter as parallel one is offered. Its application allows reducing weight of a choke of the passive filter

Development of the GRAiNITA prototype with ZnWO<inf>4</inf> and BGO crystal grains

International audienceWe will present the development of two medium-size prototypes of GRAiNITA, a next-generation shashlik calorimeter, based on the use of ZnWO4and BGO crystal grains, respectively, soaked in a high-density and high-refractive index liquid. As in the LiquidO detection technique[1], due to the presence of the grains, the scintillation light remains stochastically confined in the area of production; for this reason, it can be collected and transferred towards the photodetectors by the use of wavelength shifting fibers evenly distributed in the detection volume, similarly as in a conventional shashlik calorimeter.GRAiNITA represents a very appealing electromagnetic calorimeter candidate for high energy physics experiments for future electron-positron colliders. Indeed, due to the extreme fine sampling, GRAiNITA has the potential to reach a photon energy resolution of R~2%/sqrt(E) [2], thus increasing the precision of flavor physics with rare decays to photons or neutral pions. In this communication, we will present the outcomes of the study that led us to the choice of the best suited fibers for ZnWO4and BGO, respectively, and we will present the effect observed on the light propagation, when adding isopropanol in the detection volume (as a first approximation of future liquids), to fill the space between the crystal grains. Finally, we will discuss the development and characterization of the prototypes, presenting either the mechanical and the electronic design

First characterization of a novel grain calorimeter: the GRAiNITA prototype

International audienceA novel type of calorimeter based on grains of inorganicscintillating crystal readout by wave length shifting fibers isproposed. The concept and main features as well as the prototypedesign are introduced and the first results obtained using cosmicrays are presented. The number of photo-electrons generated bycosmic rays muons in the prototype detector is estimated to be ofthe order of 10000 photo-electrons per GeV, validating the conceptof this next-generation shashlik calorimeter

Search for Very-Short-Baseline Oscillations of Reactor Antineutrinos with the SoLid Detector

International audienceIn this letter we report the first scientific result based on antineutrinos emitted from the BR2 reactor at SCK CEN. The SoLid experiment uses a novel type of highly granular detector whose basic detection unit combines two scintillators, PVT and 6LiF:ZnS(Ag), to measure antineutrinos via their inverse-beta-decay products. An advantage of PVT is its highly linear response as a function of deposited particle energy. The full-scale detector comprises 12800 voxels and operates over a very short 6.3--8.9 m baseline from the reactor core. The detector segmentation and its 3D imaging capabilities facilitate the extraction of the positron energy from the rest of the visible energy, allowing the latter to be utilised for signal-background discrimination. We present a result based on 280 reactor-on days (55 MW mean power) and 172 reactor-off days, respectively, of live data-taking. A total of 29479 $\pm$ 603 (stat.) antineutrino candidates have been selected, corresponding to an average rate of 105 events per day and a signal-to-background ratio of 0.27. A search for disappearance of antineutrinos to a sterile state has been conducted using complementary model-dependent frequentist and Bayesian fits, providing constraints on the allowed region of the Reactor Antineutrino Anomaly

Search for Very-Short-Baseline Oscillations of Reactor Antineutrinos with the SoLid Detector

International audienceIn this letter we report the first scientific result based on antineutrinos emitted from the BR2 reactor at SCK CEN. The SoLid experiment uses a novel type of highly granular detector whose basic detection unit combines two scintillators, PVT and 6LiF:ZnS(Ag), to measure antineutrinos via their inverse-beta-decay products. An advantage of PVT is its highly linear response as a function of deposited particle energy. The full-scale detector comprises 12800 voxels and operates over a very short 6.3--8.9 m baseline from the reactor core. The detector segmentation and its 3D imaging capabilities facilitate the extraction of the positron energy from the rest of the visible energy, allowing the latter to be utilised for signal-background discrimination. We present a result based on 280 reactor-on days (55 MW mean power) and 172 reactor-off days, respectively, of live data-taking. A total of 29479 $\pm$ 603 (stat.) antineutrino candidates have been selected, corresponding to an average rate of 105 events per day and a signal-to-background ratio of 0.27. A search for disappearance of antineutrinos to a sterile state has been conducted using complementary model-dependent frequentist and Bayesian fits, providing constraints on the allowed region of the Reactor Antineutrino Anomaly