JUVENTUDE E VIOLÊNCIA: VULNERABILIDADES, ESTIGMATIZAÇÃO E TERRITÓRIO

Resumo A vulnerabilidade social ganha destaque na década de 1990, ao substituir os estudos relacionados apenas à pobreza pela compreensão de que um conjunto de desvantagens sociais mais abrangentes influencia na condição dos sujeitos. Este trabalho corresponde a uma pesquisa de natureza qualitativa e utiliza como fonte para coleta de dados a pesquisa bibliográfica, fundamentando-se, precipuamente em Abramovay (2002), Castro e Abramovay (2004), Bezerra (2012) e Sena (2013). Seu objetivo é discutir a relação existente entre a juventude e a situação de vulnerabilidade à violência, não perdendo de vista as particularidades das vulnerabilidades social, positiva, negativa e socioespacial, assim como a reflexão sobre os jovens residentes em periferias, os quais são alvos frequentes da estigmatização social e midiática, devido seus territórios de residência e a presença frequente nas elevadas taxas de homicídios

AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer

Depletion of cellular energy activates the AMP-activated protein kinase (AMPK) to favor energy-producing catabolic processes during tumorigenesis. Using a panel of in vitro cell lines and resected tumors, we investigated the therapeutic value of manipulating AMPK in prostate cancer (PC). Phospho-AMPK expression was significantly elevated in human PC cells and clinical PC samples. In clinical PC, we observed a trend for increasing phospho-AMPK with increasing Gleason sum score; Phospho-AMPK expression was associated with phospho-ACC (p=0.0023). Using the paired PC3 and PC3M cells to model progressive androgen-independent PC, treatment with either 5-aminoimidazole-4-carboxamide riboside (AICAR) or A-769662 suppressed proliferation, migration and invasion in both cell lines, and down-regulated mTOR and P70S6Ki levels regardless of the Akt status. Involvement of AMPK was confirmed by Compound C (AMPK inhibitor) and siRNA-mediated AMPK silencing. Despite similar functional responses in PC3 and PC3M cells, AMPK activation resulted in sustained phospho-Akt activation in PC3M cells, but not in PC3 cells. This prompted the addition of the PI3K inhibitor LY-294002 to AICAR treatment of PC3M cells in a proliferation assay. Interestingly, we found no synergistic effects upon combined treatment. Collectively, these findings support AMPK as a potential therapeutic target independent of PI3K/Akt signalling

Health Literacy among the Adolescent Girls: A Socio-Economic Analysis of the Adolescent Girls of Darrang District, Assam

In the present century the most needed quality that every society should have is the “Health Literacy”. In this century where we are facing pandemics, where people are witnessing or to be specific suffering from various savage troubles people are really required to be conscious about their health. We have chosen to study this problem more importantly from the perspective of adolescent girls as adolescence is the most critical age of development full of multifaceted problems and challenges. They not only experience rapid developmental changes but also face various psycho-social trauma and anxiety. We have chosen Darrang district as our subject area to study.  We have sufficiently made investigation on the issue to grasp the real scenario. This paper will surely throw light on the rate of health consciousness or literacy among the adolescent girls of this specific area. If there is any inefficiency then through this paper, we will make effort to provide probable solution to it. We have properly studied the adolescent girls between the age of 12 to 18 through primary and secondary sources. We have used survey as well as personal interview among the subject to find out the outcome

A new approach to stopped-flow reactions for slurry and gas-phase olefin polymerization

Given the industrial relevance of polyolefin production, it is certainly of great interest to understand the phenomena taking place during the reaction start-up. The first few seconds, or fractions of a second, are a determining moment in which morphology formation takes place and where the risk of particle overheating is at its highest. Nevertheless, the main drawback to studying these early stages is the lack of adapted apparatus that allow collecting accurate experimental data. It is, therefore, useful to have specifically designed tools for different processes. In this work, a combined approach of slurry and gas-phase systems was taken to evaluate the initial conditions of catalyst treatment for nascent olefin polymerization in supported catalysts. A rapid-quench slurry system was set up to perform polymerization reactions. Unlike previous works1, in which the stopped-flow technique was applied using separate vessels interconnected by tubes, our set-up was conceived in a single vessel under mechanical agitation and the reaction quenching was done by pressurized CO2. In parallel, a new stopped-flow gas-phase reactor has been developed for olefin polymerization, aiming to improve certain aspects of previous versions developed over the past few years in the C2P2 lab2–5. Our aims were to increase the polymer production capacity and reduce risks of temperature gradients formation inside the reactor, allowing for more accurate kinetic studies in the nascent polymerization phase. A solid porous membrane was incorporated inside the reactor, aiming to improve the gas convection and reduce the possibility of temperature gradients inside the reactor. The main goal of this study was to compare the impact of initial conditions of catalyst treatment in slurry and gas-phase under industrially relevant conditions and collect experimental data on important phenomena such as catalyst fragmentation and particle morphology development. Following steps include building up a physical interpretation of the impact of the startup conditions on initial particle overheating, reaction rate and morphology (fragmentation). (1) Liu, B.; Matsuoka, H.; Terano, M. Stopped-Flow Techniques in Ziegler Catalysis. Macromol. Rapid Commun. 2001, 22 (1), 1–24. (2) Olalla, B.; Broyer, J.-P.; McKenna, T. F. L. Heat Transfer and Nascent Polymerisation of Olefins on Supported Catalysts. Macromol. Symp. 2008, 271 (1), 1–7. (3) Silva, F. M.; Broyer, J. P.; Novat, C.; Lima, E. L.; Pinto, J. C.; McKenna, T. F. Investigation of Catalyst Fragmentation in Gas-Phase Olefin Polymerisation: A Novel Short Stop Reactor. Macromol. Rapid Commun. 2005, 26 (23), 1846–1853. (4) Tioni, E.; Broyer, J. P.; Spitz, R.; Monteil, V.; McKenna, T. F. L. Heat Transfer in Gas Phase Olefin Polymerisation. Macromol. Symp. 2009, 285 (1), 58–63. (5) Tioni, E.; Spitz, R.; Broyer, J. P.; Monteil, V.; McKenna, T. Packed-Bed Reactor for Short Time Gas Phase Olefin Polymerization: Heat Transfer Study and Reactor Optimization. AIChE J. 2012, 58 (1), 256–267

PERTANGGUNGJAWABAN NOTARIS ATAS PEMBATALAN AKTA OTENTIK OLEH PUTUSAN PENGADILAN BERDASARKAN UU NO. 2 TAHUN 2014 JO. UU NO. 30 TAHUN 2004

Penelitian dengan judul ”Pertanggungjawaban Notaris Atas Pembatalan Akta Otentik Oleh Putusan Pengadilan Berdasarkan UU No. 2 tahun 2014 jo. UU No. 30 Tahun 2004”bertujuan untuk menegetahui pertanggung jawaban notaris atas akta otentik yang di buatnya hal ini karena akta otentik yang di buat notaris bisa di batalkan oleh pengadilan sehingga apa bila ada pihak yang di rugikan atas akta otentik dapat mengajukan pembatalan akta otentik tersebut, sehingga atas batalnya akta otentik tersebut notaris dapat di mintai pertanggung jawaban. Penelitian ini menggunakan pendekatanyuridis normative, dalam pengumpulan data lebih ditekankan pada sumber bahan primer, berupa peraturan perundang-undangan, menelaah kaidah-kaidah hukum maupun teori ilmu hukum sera di tambah dengan wawancara kepada para pihak yang terkait dengan masalah yang di teliti. Berdasarkan metode tersebut penelitian menghasilkan pada pokoknya (1) Kewenangan pengadilan dalam pembatalan akta otentik yang di buat notaris adalah berdasarkan mendasarkan pada undang-undang yang berlaku, yang pada umumnya sama dengan alasan-alasan yuridis batalnya perjanjian yang tidak memenuhi syarat subjektif sahnya perjanjian sebagaimana tersebut dalam Pasal 1320 KUHPerdata, (2) Akhibat hukum akta otentik yang di batalkan oleh putusan pengadilan maka akta otentik yang di buat Notaris terdegradasi nilai pembuktiannya sebagai akta dibawah tangan hal ini berdasarkan KUHperdata pasal 1869 serta dapat dilihat pada UU No. 2 Tahun 2014 jo. UU No. 30 Tahun 2004 Pasal 16 angka (9), Pasal 41, Pasal 44, Pasal 48 ayat (3) Pasal 49 ayat (4), Pasal 50 ayat (5), Pasal 51 ayat (4). (3) Pertanggung Jawaban notaris atas pembatalan akta otentik yang oleh putusan pengadilanberdasarkan UU No. 2 Tahun 2014 jo. UU No. 30 Tahun 2004 pada prinsipnya Notaris dapat di mintai pertanggungjawaban yaitu ; (a) Pertanggungjawaban secara administratif Apabila seorang notaris terbukti melakukan pelanggaran pasal 85 Undang-undang Nomor 30 Tahun 2004 yang mengatur mengenai kewajiban dan larangan bagi notaris dalam menjalankan jabatannya.(b)Pertanggungjawaban menurut Hukum Perdata hal ini sebagaimana Pasal 1365 KUHPerdata, serta dapat dilihat pada UU No. 2 Tahun 2014 jo. UU No. 30 Tahun 2004 Pasal 16 angka (9), Pasal 41, Pasal 44, Pasal 48 ayat (3) Pasal 49 ayat (4), Pasal 50 ayat (5), Pasal 51 ayat (4). (b)Pertanggungjawaban menurut hukum pidana apabila notaris sengaja memalsukan akta otentik atau sengaja memasukan keterangan tidak benar dalam akta otentik yang di buatnya Kata kunci : Akta Otentik, Notaris, Pertanggung Jawaba

La condición laboral del director y la calidad de gestión en las instituciones educativas de la red 8 - unidad de gestión educativa local 05 San Juan de Lurigancho / El Agustino

La presente investigación parte del problema si hay relación o no entre la calidad de gestión y la condición laboral del director, de allí que tuvo como objetivo determinar la relación entre la calidad de gestión y la condición laboral del director en las instituciones educativas de la red 8 unidad de gestión local 05 San Juan de Lurigancho / El Agustino. El método de investigación fue correlaciona! que recogió la información en un periodo específico de una población que estuvo conformada por 140 miembros de la comunidad educativa los cuales fueron directores profesores alumnos y padres de familia. Para correlacionar las variables condición laboral del director y calidad de gestión se aplicó los instrumentos de la Matriz de evaluación de la calidad de gestión de IPEBA. En la contratación de la hipótesis se utilizó el estadístico Chi cuadrada. Los resultados de la investigación nos demuestran que existe relación significativa entre la condición laboral del director nombrado que la del director encargado

ANALYSIS OF LABVERDE SEAL INDICATORS APPLIED TO CONSOLIDATED URBAN AREAS – THE NORTH-SOUTH TRAIL

It is seen currently the sustainability movement gaining strength in the media, in social and collective movements, political agendas and even in the daily routine. The limits of modernity, mainly regarding to the consequences of the current development model, are becoming more and more explicit. But despite being this move a strong trend, the transformation process is complex and riddled with doubts. Which are the implications of being sustainable? How to exercise sustainability? How to practice it effectively?This article aims to reflect on the questions about the sustainability in consolidated urban areas and for such purpose it analyzes one of the possible. Paths between the Cantareira Park and Ibirapuera Park, in São Paulo-SP, under the perspective of the indicators proposed by the Labverde Seal, which was  designed by the Laboratório Verde (Green Laboratory) at FAU-USP.The Labverde Seal was developed in order to ensure the sustainable practices adopted by regions and projects considering different scales, from local to regional, what makes this certification process different of other currently existing systems.The approach proposed by Labverde allows a deeper analysis of the project, since the sustainability concept, as understood today, requires consideration of a broader perspective.“Já não é aceitável construir edificações de alto desempenho em uma área não urbanizada, em um contexto dependente de automóveis, e certificá-la como sustentável”. Douglas Farr (2013)Atualmente vemos o movimento pela sustentabilidade ganhar força na mídia, em movimentos sociais e coletivos, nas agendas políticas e até em nosso dia-a-dia. Os limites da nossa modernidade, principalmente no que diz respeito às consequências do modelo de desenvolvimento em curso, estão cada vez mais explícitos. Mas apesar deste movimento ser uma forte tendência, o processo de transformação é complexo e permeado de dúvidas. Quais as implicações de ser sustentável? Como exercer a sustentabilidade? Como praticá-la de forma efetiva?O presente artigo se propõe a refletir sobre os questionamentos a respeito da sustentabilidade em áreas urbanas consolidadas e para tal analisa um dos possíveis trajetos entre o Parque Estadual da Cantareira e o Parque do Ibirapuera, na cidade de São Paulo-SP, sob a ótica dos indicadores propostos pelo Selo Labverde, Selo este concebido pelo Laboratório Verde da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo.O Selo Labverde foi desenvolvido com o intuito de certificar as práticas sustentáveis adotadas por regiões e empreendimentos considerando diversas escalas, da local a regional, o que diferencia este processo de certificação dos demais sistemas atualmente existentes.A abordagem proposta pelo Labverde permite uma análise mais aprofundada do empreendimento, uma vez que o próprio conceito de sustentabilidade, como entendido na atualidade, exige a consideração de uma perspectiva ampliada

La inteligencia emocional y el clima institucional de los docentes de la Institución Educativa Nº 1174 Virgen del Carmen del distrito de San Juan de Lurigancho, 2012

La presente investigación parte del problema si hay relación o no entre la inteligencia emocional y clima institucional, de allí que tuvo como objetivo determinar la relación entre la inteligencia emocional de los docentes y el clima institucional en la institución educativa Nº1174 Virgen del Carmen del distrito de San Juan de Lurigancho, 2012. El método de investigación fue descriptivo, la investigación utilizó para su propósito, el diseño correlacional, que recogió la información en un periodo específico de una a población que estuvo conformada por 57 docentes, docentes varones y mujeres, en los que se han correlacionado las variables Inteligencia Emocional y Clima Institucional para lo cual se aplicó los instrumentos: inventario de Baron ice y el inventario de Inteligencia Emocional. Cada uno de los inventarios ha pasado por el Alfa de Cronbach. En la contrastación de la hipótesis se ha utilizado el Chi cuadrado. Los resultados de la investigación nos llevó a la conclusión que existe correlación significativa entre la inteligencia emocional y el clima institucional de los docentes de la institución educativa Nº1174 Virgen del Carmen del distrito de San Juan de Lurigancho, 2012

Requerimiento de certificado de salud mental como requisito para personas mayores de 60 años en transferencias de propiedad Inmueble Notarial

Determinar si existe la necesidad de requerir certificado de salud mental como requisito para personas mayores de 60 años en transferencia de propiedad inmueble surge de la problemática de que si existe la necesidad de requerir certificado de salud mental como requisito, ya que no se encuentra regulado en el decreto legislativo del notariado 1049 y queademás existen notarias que no solicitan este certificado ya que no lo consideran como un requisito esencial. Debido a este incumplimiento e inexistencia de uniformidad en la presentación de certificado de salud mental en las notarías del país, se interponen demandas para la nulidad del acto jurídico en transferencia de propiedad. La investigación tiene como bases teóricas la manifestación de voluntad, certificado de saludmental, la fe pública, el adulto mayor y otros temas que se encuentran en la investigación. La investigación es básica, debido a las entrevistas realizadas a conocedores del tema y especialistas se llega a la conclusión que se debe considerar incluir dentro de la ley del notariado 1049 como requisito el certificado de salud mental para los procedimientos notariales y así proteger al adulto mayor en el aspecto social, económico y jurídic

Ocorrência de achados radiográficos em pacientes pediátricos

INTRODUCTION: Panoramic radiography allows the dentist to better visualize the structures that make up the dentomaxillofacial complex, in order to assist in the diagnosis of pathologies that affect this region. In pediatric dentistry, this test, in addition to being better tolerated by children because it does not require intraoral devices, also represents an important complementary tool in the diagnosis of the changes that occur in the dentomaxillofacial complex. OBJECTIVE: To investigate the imaging findings in panoramic radiographs of pediatric patients. METHODS: A total of 512 digital panoramic radiographs of patients up to 10 years of age, both sexes, belonging to the database of the Department of Dentistry of UFRN were analysed. The dependent variables investigated in the radiographic images were the presence or absence of dental anomalies, dental resorptions and pathological processes affecting maxillary teeth and bones. Observed radiographic findings were associated with sex and age (Chi-square and Fisher's Exact, p≤0.05). RESULTS: 51.4% of the sample of radiographics were male and 48.6% female. Age ranged from 3 to 10 years of age (mean 7.86 years). The most frequent findings were apical bone rarefaction (21.5%), hypodontia (9.2%) and hyperdontia (9.2%). Male subjects had a higher occurrence of hyperdontia (p = 0.003). Children up to 8 years of age presented a higher occurrence of diffuse apical bone rarefaction (p = 0.000), while children above 8 years had a higher occurrence of impacted teeth (p = 0.002). CONCLUSION: Hyperdontia, hypodontia and apical bone rarefaction were the most prevalent alterations in patients up to 10 years of age.INTRODUÇÃO: A radiografia panorâmica possibilita ao cirurgião-dentista uma melhor visualização das estruturas que compõem o complexo dentomaxilofacial, de forma a auxiliar no diagnóstico de patologias que acometem essa região. Na odontopediatria, esse exame, além de ser melhor tolerado pelas crianças em função de não necessitar de dispositivos intraorais, representa também uma importante ferramenta complementar no diagnóstico das alterações que ocorrem no complexo dentomaxilofacial. OBJETIVO: Investigar os achados imagenológicos em radiografias panorâmicas de pacientes pediátricos. METODOLOGIA: Foram analisadas 512 radiografias panorâmicas digitais de pacientes de até 10 anos de idade, ambos os sexos, pertencentes ao banco de dados do Serviço de Imagenologia do Departamento de Odontologia da UFRN. As variáveis dependentes investigadas nas imagens radiográficas foram a presença ou ausência de anomalias dentárias, reabsorções dentárias e processos patológicos que afetam os dentes e ossos maxilares. Achados radiográficos observados foram associados com o sexo e idade (Qui-quadrado e Exato de Fisher, p≤0,05). RESULTADOS: 51,4% da amostra das radiografias eram do sexo masculino e 48,6% do sexo feminino. A idade variou de 3 a 10 anos de idade (média 7,86 anos). Os achados mais frequentes foram rarefação óssea apical (21,5%), hipodontia (9,2%) e hiperdontia (9,2%). Indivíduos do sexo masculino apresentaram uma maior ocorrência de hiperdontia (p=0,003). Crianças com até 8 anos de idade apresentaram uma maior ocorrência de rarefação óssea apical (p=0,000), enquanto crianças acima de 8 anos apresentaram uma maior ocorrência de dentes impactados (p=0,002). CONCLUSÃO: A hiperdontia, hipodontia e a rarefação óssea apical difusa foram as alterações mais prevalentes nos pacientes de até 10 anos de idade