Part II

The molecular mechanisms of the pharmacological action of SS-68 were chosen as the focus for this study. From the point of view of molecular pharmacology, SS-68 can be attributed to an antiarrhythmic drug with a mixed type of actio

Development perspectives of new generation medications based on the redox system regulators

This survey paper describes the necessity of the development of new medications influencing the body redox-potential. It supports the most pressing branch of pharmacology, which coincides with logically relevant attempts to shift paradigm of pharmacology from molecular to electronic, quantum-wave. This article covers and logically assorts research results of recent years and opinions of wide range of scientists from various countries. The authors also give their own assessment of the possibility to influence body redox potential. It is reported that some biophysical achievements regarded undoubtedly put a new spin in pharmacology of the biophysical leve

Pharmacokinetic studies derived indole SS-68 with antiarrhythmic and antianginal properties

A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spectrometric detector (HPLCMS/ MS). Conducted pharmacokinetic studies SS-68 in the body of rabbits. Set the main pharmacokinetic parameters of the substance that allow you to optimize the future use of it’s as a potential drug in cardiology practic

Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action

A promising compound for the treatment of inflammatory periodontal diseases is benzofuracaine (BFC). BFC has pronounced anti-inflammatory, analgesic, reparative, hypoglycemic and other effects. Objective: To assess the influence of benzofuracaine on experimental periodontitis and to study its antidiabetic activity and molecular mechanisms of actio

Effects of dimephosphone on skin survival in conditions of reduced blood circulation

The search for and creation of drugs with dermatoprotective and metabotropic activity is one of the priorities of modern diabetology. Synthetic organophosphorus compounds with no anticholinesterase activity, to which dimephosphone belongs to, deserve great attention in this respec

Part I

The problem of heart rhythm disturbances is one of the most urgent topics of modern cardiology. According to the currently available concepts, 1,2- and 1,3-disubstituted aminoindole derivatives, which compound 2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1H-indole hydrochloride (SS-68) belongs to, are a promising chemical group in terms of their cardio-pharmacological activit

The transition from the ballistic to the diffusive regime in a turbid medium

By varying the absorption coefficient and width of an intralipid- India ink solution in a quasi one-dimensional experiment, the transition between the ballistic and the diffusive regimes is investigated. The medium's attenuation coefficient changes abruptly between two different values within a single mean-free-path. This problem is analyzed both experimentally and theoretically, and it is demonstrated that the transition location depends on the scattering coefficient as well as on the measuring solid angle.Comment: 2 Figure

The role of catecholamines, melatonin and nitric oxide in the mechanisms of stress damage to the body

The mechanisms of response and adaptation of the body’s regulatory systems to stress factors is an urgent fundamental task and the goal of this study. The study used four experimental models of stress: acute stress, chronic stress, and their sequence

Study of the selective phenolic inhibitors of arginase 2 acute toxicity

We have previously shown that the isolated arginase 2 inhibitors have a pronounced endothelioprotective level. A strategy is proposed for the targeted search for isolated arginase 2 inhibitors among compounds of a phenolic nature. Received 3 compounds, isolated arginase inhibitors 2. As a result of the study, the acute toxicity of the compounds obtained was studie