Employee Motivation and It’s Influence on Performance

The purpose of this paper is to highlight the relationship or the impact motivation of employees have on their overall performance in organizations and how their performance as well boost the overall output of their organizations.The objective of this paper is to educate readers on some theories of motivation mainly the content/need theories which talks about what motivates employees with various authors and their findings, and he process theories which explains employee’s levels of motivation and need satisfaction.The study also focuses on the types of motivation and the forms they take with further literature talking about the importance of motivation and how it influences employees’ performance and how this performance can be measured.Finally, with all the findings and that of various authors the paper has concluded that the success and achievements of organizations depends on how well they motivate their employees and in every organization employees would like managers who motivate them in the workforce

Observational Signatures of Carbon-Oxygen White Dwarf Merger Remnants

Many double white dwarf (WD) mergers likely do not lead to a prompt thermonuclear explosion. We investigate the prospects for observationally detecting the surviving remnants of such mergers, focusing on the case of mergers of Carbon-Oxygen WDs. For $\sim 10^4$ yr, the merger remnant is observationally similar to an extreme AGB star evolving to become a massive WD. Identifying merger remnants is thus easiest in galaxies with high stellar masses (high WD merger rate) and low star formation rates (low birth rate of $\sim 6-10 \,{\rm M_{\odot}}$ stars). Photometrically identifying merger remnants is challenging even in these cases because the merger remnants appear similar to He stars and post-outburst classical novae. We propose that the most promising technique for discovering WD merger remnants is through their unusual surrounding photoionized nebulae. We use CLOUDY photoionization calculations to investigate their unique spectral features. Merger remnants should produce weak hydrogen lines and strong carbon and oxygen recombination and fine-structure lines in the UV, optical and IR. With integral field spectrographs, we predict that hundreds of candidates are detectable in M87 and other nearby massive galaxies. Dust somewhat reduces the optical line emission for nebula radii $\lesssim 10^{17}$ cm, but the sources spend most of their time with larger radii when dust is less important. Our models roughly reproduce the WISE nebula surrounding the Galactic WD merger candidate IRAS 00500+6713; we predict detectable [Ne VI] and [Mg VII] lines with JWST but that the mid-IR WISE emission is dominated by dust not fine-structure lines.Comment: 12 pages, 8 figures, 2 tables, submitted to MNRA

Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells

While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents. Here we examined the effect of two FDA-approved dopamine modulators, fluphenazine and trifluoperazine, on mammary tumor cells, osteoclasts, osteoblasts, and osteocytes. These agents suppressed proliferation and migration of mammary tumor cells chiefly by antagonizing dopamine receptor D2 and reduced bone resorption by downregulating nuclear factor of activated T cells, cytoplasmic 1 (Nfatc1). Three-dimensional spheroid formation assays revealed that tumor cells have high affinity to osteocytes and type I collagen, and interactions with osteocytes as well as administration of fluphenazine and trifluoperazine downregulated Snail and suppressed migratory behaviors. Unlike the inhibitory action of fluphenazine and trifluoperazine on tumor growth, tumor-osteocyte interactions stimulated tumor proliferation by upregulating NFκB and Akt. In the bone microenvironment, osteocytes downregulated Snail and acted as an attractant as well as a stimulant to mammary tumor cells. These results demonstrate that tumor-osteocyte interactions strengthen dopamine receptor-mediated suppression of tumor migration but weaken its inhibition of tumor proliferation in the osteocyte-rich bone microenvironment.Significance: These findings provide novel insight into the cellular cross-talk in the bone microevironment and the effects of dopamine modulators on mammary tumor cells and osteocytes. Cancer Res; 78(14); 3865-76. ©2018 AACR

The Determinants of Acceptance of Recommender Systems: Applying the UTAUT Model

This study investigates how consumers assess the quality of two types of recommender systems, collaborative filtering and content-based, in the content of e-commerce by using a modified Unified Theory of Acceptance and Use of Technology (UTAUT) model. Specifically, the under-investigated concept of trust in technological artifacts is adapted to a modified UTAUT model. Additionally, this study considers hedonic and utilitarian product characteristics, attempting to present a comprehensive range of recommender system acceptance. A total of 51 participants completed an online 2 (recommender systems) x 2 (products) survey. The results suggested that type of recommender systems and products did have different impacts on the behavioral intention to use recommender systems. This study may be of importance in explaining factors contributing to use recommender systems, as well as in providing designers of recommender systems with a better understanding of how to provide a more effective recommender system

Seasonal fluxes and sources apportionment of dissolved inorganic nitrogen wet deposition at different land-use sites in the Three Gorges reservoir area.

To identify seasonal fluxes and sources of dissolved inorganic nitrogen (DIN) wet deposition, concentrations and δ15N signatures of nitrate (NO3−) and ammonium (NH4+) in wet precipitation were measured at four typical land-use types in the Three Gorges reservoir (TGR) area of southwest China for a one-year period. Higher DIN fluxes were recorded in spring and summer and their total fluxes (averaged 7.58 kg N ha−1) were similar to the critical loads in aquatic ecosystems. Significant differences of precipitation δ15N were observed for NH4+-N between town and wetland sites in spring and between urban and rural sites in summer. For NO3−-N, significant differences of precipitation δ15N were observed between town and rural sites in spring and between urban and town sites in autumn, respectively. Quantitative results of NO3−-N sources showed that both biomass burning and coal combustion had higher fluxes at the urban site especially in winter (0.18 ± 0.09 and 0.19 ± 0.08 kg N ha−1), which were about three times higher than those at the town site. A similar finding was observed for soil emission and vehicle exhausts in winter. On the whole, DIN wet deposition averaged at 12.13 kg N ha−1 yr−1 with the urban site as the hotspot (17.50 kg N ha−1 yr−1) and regional NO3−-N fluxes had a seasonal pattern with minimum values in winter. The contribution to NO3−-N wet deposition from biomass burning was 26.1 ± 14.1%, which is the second dominant factor lower than coal combustion (26.5 ± 12.6%) in the TGR area during spring and summer. Hence N emission reduction from biomass burning, coal combustion and vehicle exhausts should be strengthened especially in spring and summer to effectively manage DIN pollution for the sustainable development in TGR area

A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs.

mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown whether RNAs play any role in this process. Unexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' processing complex. These snoRNAs primarily interact with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF). We have functionally characterized one of these snoRNAs and our results demonstrated that the U/A-rich SNORD50A inhibits mRNA 3' processing by blocking the Fip1-poly(A) site (PAS) interaction. Consistently, SNORD50A depletion altered the Fip1-RNA interaction landscape and changed the alternative polyadenylation (APA) profiles and/or transcript levels of a subset of genes. Taken together, our data revealed a novel function for snoRNAs and provided the first evidence that non-coding RNAs may play an important role in regulating mRNA 3' processing

Grounded Decoding: Guiding Text Generation with Grounded Models for Embodied Agents

Recent progress in large language models (LLMs) has demonstrated the ability to learn and leverage Internet-scale knowledge through pre-training with autoregressive models. Unfortunately, applying such models to settings with embodied agents, such as robots, is challenging due to their lack of experience with the physical world, inability to parse non-language observations, and ignorance of rewards or safety constraints that robots may require. On the other hand, language-conditioned robotic policies that learn from interaction data can provide the necessary grounding that allows the agent to be correctly situated in the real world, but such policies are limited by the lack of high-level semantic understanding due to the limited breadth of the interaction data available for training them. Thus, if we want to make use of the semantic knowledge in a language model while still situating it in an embodied setting, we must construct an action sequence that is both likely according to the language model and also realizable according to grounded models of the environment. We frame this as a problem similar to probabilistic filtering: decode a sequence that both has high probability under the language model and high probability under a set of grounded model objectives. We demonstrate how such grounded models can be obtained across three simulation and real-world domains, and that the proposed decoding strategy is able to solve complex, long-horizon embodiment tasks in a robotic setting by leveraging the knowledge of both models. The project's website can be found at grounded-decoding.github.io

Lasting DNA Damage and Aberrant DNA Repair Gene Expression Profile Are Associated with Post-Chronic Cadmium Exposure in Human Bronchial Epithelial Cells

Cadmium (Cd) is a widespread environmental pollutant and carcinogen. Although the exact mechanisms of Cd-induced carcinogenesis remain unclear, previous acute/chronic Cd exposure studies have shown that Cd exerts its cytotoxic and carcinogenic effects through multiple mechanisms, including interference with the DNA repair system. However, the effects of post-chronic Cd exposure remain unknown. Here, we establish a unique post-chronic Cd-exposed human lung cell model (the CR0 cells) and investigate the effects of post-chronic Cd exposure on the DNA repair system. We found that the CR0 cells retained Cd-resistant property even though it was grown in Cd-free culture medium for over a year. The CR0 cells had lasting DNA damage due to reduced DNA repair capacity and an aberrant DNA repair gene expression profile. A total of 12 DNA repair genes associated with post-chronic Cd exposure were identified, and they could be potential biomarkers for identifying post-chronic Cd exposure. Clinical database analysis suggests that some of the DNA repair genes play a role in lung cancer patients with different smoking histories. Generally, CR0 cells were more sensitive to chemotherapeutic (cisplatin, gemcitabine, and vinorelbine tartrate) and DNA damaging (H2O2) agents, which may represent a double-edged sword for cancer prevention and treatment. Overall, we demonstrated for the first time that the effects of post-chronic Cd exposure on human lung cells are long-lasting and different from that of acute and chronic exposures. Findings from our study unveiled a new perspective on Cd-induced carcinogenesis-the post-chronic exposure of Cd. This study encourages the field of post-exposure research which is crucial but has long been ignored

Realization of Polarization Control in High-Order Harmonic Generation

The nature of high-order harmonic generation process limits the harmonics emission to linear polarization. In this paper, we review the recent progress to generate elliptically or circularly polarized high-harmonic EUV pulses. We further demonstrate how complete control of polarization state of isolated high-harmonic pulse can be realized today by noncollinear focusing of two driving pulses with identical ellipticity but counter-rotating helicity. This paper opens a path towards the study of the fastest dynamics--down to attosecond time scales--in circular dichroism of magnetic materials, chiral molecules, and electronic spin motion.Taiwan Ministry of Science and Technology; Academia Sinica; Junta de Castilla y León; Ministerio de Economía y Competitividad; Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation; Ministerio de Ciencia, Innovación y Universidades for a Ramón y Cajal; European Social Fund; Ministerio de Educación, Cultura y Deporte