de Broglie-Bohm Interpretatin for Analytic Solutions of The Wheeler-DeWitt Equation in Spherically Symmetric Space-time

We discuss the implications of a wave function for quantum gravity, which involves nothing but 3-dimensional geometries as arguments and is invariant under general coordinate transformations. We derive an analytic wave function from the Wheeler-DeWitt equation for spherically symmetric space-time with the coordinate system arbitrary. The de Broglie-Bohm interpretation of quantum mechanics is applied to the wave function. In this interpretation, deterministic dynamics can be yielded from a wave function in fully quantum regions as well as in semiclassical ones. By introducing a coordinate system additionally, we obtain a cosmological black hole picture in compensation for the loss of general covariance. Our analysis shows that the de Broglie-Bohm interpretation gives quantum gravity an appropriate prescription to introduce coordinate systems naturally and extract information from a wave function as a result of breaking general covariance.Comment: 14 pages, REVTeX; abstract and content revise

Advances and technical challenges in development of CMC

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Offshore-origin warm water inflows toward Totten Ice Shelf, East Antarctica

The Tenth Symposium on Polar Science/Ordinary sessions: [OM] Polar Meteorology and Glaciology, Thu. 5 Dec. / 2F Auditorium , National Institute of Polar Researc

Nutrition Support for Head and Neck Squamous Cell Carcinoma Patients Treated with Chemoradiotherapy: How Often and How Long?

Background. Oral intake of many patients with locally advanced head and neck cancer (LAHNC) decrease during chemoradiotherapy (CRT). Although prophylactic percutaneous endoscopic gastrostomy (PEG) is recommended, not a few patients complete CRT without using PEG tube. Patients and Methods. The subjects were patients with LAHNC who received CRT. We retrospectively investigated the incidence and duration of nutritional support during and after CRT, and predicting factors of nutritional support. For patients who required nutritional support, we also checked the day of initiation and the duration of nutritional support. Results. Of 53 patients, 29 patients (55%) required nutritional support during and/or after CRT. While no clear relation between requirement of nutritional support and variables including age, T stage, N stage, clinical stage and chemotherapy regimen, there could be some relationships between tumor primary sites and the requirement and duration of nutritional support. 17 (77%) of 22 patients with oropharynx cancer(OP) required nutritional support and prolonged for 4.4 months, and 11 (46%) of 24 patients with hypopharynx cancer(HP) required nutritional support and prolonged for 21.9 months. Conclusion. Nutritional support is indicated many HNC patients treated with CRT and primary sites may have some relation to its indication and duration

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

Heparin-binding EGF-like growth factor (HB-EGF) is first synthesized as a membrane-anchored form (proHB-EGF), and its soluble form (sHB-EGF) is released by ectodomain shedding from proHB-EGF. To examine the significance of proHB-EGF processing in vivo, we generated mutant mice by targeted gene replacement, expressing either an uncleavable form (HBuc) or a transmembrane domain–truncated form (HBΔtm) of the molecule. HBuc/uc mice developed severe heart failure and enlarged heart valves, phenotypes similar to those in proHB-EGF null mice. On the other hand, mice carrying HBΔtm exhibited severe hyperplasia in both skin and heart. These results indicate that ectodomain shedding of proHB-EGF is essential for HB-EGF function in vivo, and that this process requires strict control

Analytic Solutions of The Wheeler-DeWitt Equation in Spherically Symmetric Space-time

We study the quantum theory of the Einstein-Maxwell action with a cosmological term in the spherically symmetric space-time, and explored quantum black hole solutions in Reissner-Nordstrom-de Sitter geometry. We succeeded to obtain analytic solutions to satisfy both the energy and momentum constraints.Comment: LaTeX file, 15 page

de Broglie-Bohm Interpretation for the Wave Function of Quantum Black Holes

We study the quantum theory of the spherically symmetric black holes. The theory yields the wave function inside the apparent horizon, where the role of time and space coordinates is interchanged. The de Broglie-Bohm interpretation is applied to the wave function and then the trajectory picture on the minisuperspace is introduced in the quantum as well as the semi-classical region. Around the horizon large quantum fluctuations on the trajectories of metrics $U$ and $V$ appear in our model, where the metrics are functions of time variable $T$ and are expressed as $ds^2=-{\alpha^2}/U dT^2 + U dR^2 + V d\Omega^2$. On the trajectories, the classical relation $U=-V^{1/2}+2Gm$ holds, and the event horizon U=0 corresponds to the classical apparent horizon on $V=2Gm$. In order to investigate the quantum fluctuation near the horizon, we study a null ray on the dBB trajectory and compare it with the one in the classical black hole geometry.Comment: 20 pages, Latex, 7 Postscript figure

Liver Parenchyma Perforation following Endoscopic Retrograde Cholangiopancreatography

Although endoscopic retrograde cholangiopancreatography (ERCP) is an effective modality for the diagnosis and treatment of biliary and pancreatic diseases, it is still related with several severe complications. We report on the case of a female patient who developed liver parenchyma perforation following ERCP. She underwent ERCP with sphincterotomy and extraction of a common bile duct stone. Shortly after ERCP, abdominal distension was identified. Abdominal computed tomography revealed intraabdominal air leakage and leakage of contrast dye penetrating the liver parenchyma into the space around the spleen. Since periampullary perforation related to sphincterotomy could not be denied, she was referred for immediate surgery. Obvious perforation could not be found at surgery. Cholecystectomy, insertion of a T tube into the common bile duct, placement of a duodenostomy tube and drainage of the retroperitoneum were performed. She did well postoperatively and was discharged home on postoperative day 28. In conclusion, as it is well recognized that perforation is one of the most serious complication related to ERCP, liver parenchyma perforation should be suspected as a cause