Cardiovascular effects of an arginase II selective inhibitor

For the first time in vitro experiments there were studied the inhibitory activity and safety of potential molecules arginase II selective inhibitors from the group of norleucine derivatives. Also first the substance under the code ZB49-0010C from the group of norleucine derivatives showed the greatest selectivity and inhibitory activity against arginase II in experiments in vitro. However, this substance in vivo exerts dose-dependent hypotensive action and cardioprotective and endothelial protective effects on the L-NAME induced and homocysteine-induced endothelial dysfunction (ED), which are most pronounced at a dose of 10 mg/kg in intragastric administratio

Resonant photoemission spectroscopy of Cu(InGa)Se2 materials for solar cells

The electron structure of CuIn1 - x Ga x Se 2 single crystals is determined via resonant photoemis-sion and the main regularities of its transformation upon varying concentration x from 0 to 1 are established. The dependence of the shape of valence band spectra on the photon energy is studied. Integral photoemission intensities are shown to be determined by atomic photoionization cross sections. Processes of the direct and two-step creation of photoelectrons accompanying photoemission and the participation of internal states in the spectra of electrons from valence bands are studied. Two-hole final states in photoemission are obtained upon threshold excitation of the Cu 2p level. The strong interaction of holes leads to the multiplet splitting of these states. Partial densities of the components' states are determined using the energy dependence of atomic photoionization cross sections. © 2013 Allerton Press, Inc

Ion channeling in CuInSe2 single crystals

CuInSe2 single crystals are studied by the Rutherford Backscattering of 2 MeV helium ions involving axial channeling along the 〈2 2 1〉 direction of the chalcopyrite lattice. Experimental values of the critical angle and normalized minimum yield are measured and compared with theory. The concentration of point defects separately in the Cu, In, and Se sublattices, determined from the comparison of experimental and theoretical minimum yields, are estimated as 4.7 × 1020, 1.0 × 1020, and 5.7 × 1020 cm-3, respectively. © 2013 Elsevier B.V. All rights reserved

Numerical and experimental studies of the carbon etching in EUV-induced plasma

We have used a combination of numerical modeling and experiments to study carbon etching in the presence of a hydrogen plasma. We model the evolution of a low density EUV-induced plasma during and after the EUV pulse to obtain the energy resolved ion fluxes from the plasma to the surface. By relating the computed ion fluxes to the experimentally observed etching rate at various pressures and ion energies, we show that at low pressure and energy, carbon etching is due to chemical sputtering, while at high pressure and energy a reactive ion etching process is likely to dominate

A photoelectron spectroscopy study of the electronic structure evolution in CuInSe2-related compounds at changing copper content

Evolution of the valence-band structure at gradually increasing copper content has been analysed by x-ray photoelectron spectroscopy (XPS) in In2Se3, CuIn5Se8, CuIn3Se5, and CuInSe2 single crystals. A comparison of these spectra with calculated total and angular-momentum resolved density-of-states (DOS) revealed the main trends of this evolution. The formation of the theoretically predicted gap between the bonding and non-bonding states has been observed in both experimental XPS spectra and theoretical DOS

Optical properties of high quality Cu2ZnSnSe4 thin films

Cu2ZnSnSe4 thin films, fabricated on bare or molybdenum coated glass substrates by magnetron sputtering and selenisation, were studied by a range of techniques. Photoluminescence spectra reveal an excitonic peak and two phonon replicas of a donor-acceptor pair (DAP) recombination. Its acceptor and donor ionisation energies are 27 and 7 meV, respectively. This demonstrates that high-quality Cu2ZnSnSe4 thin films can be fabricated. An experimental value for the longitudinal optical phonon energy of 28 meV was estimated. The band gap energy of 1.01 eV at room temperature was determined using optical absorption spectr

Correction of retinal ischemia/reperfusion by 3-(1H-benzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in experiment

Results of ocular fundus studies revealed the most pronounced protective effects of 3-(1Hbenzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in a dose 50 mg/kg on the model of retinal ischemiareperfusion in Wistar rats, which is reflected in the restoration of the optic disc. Correction of retinal ischemiareperfusion by 3-(1H-benzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in a dose 50 mg/kg leads to higher values of the coefficient b/a of electroretinography after 72 hours of reperfusion compared to the group with pathology correction by the same drug in a dose 10 mg/kg, which indicates the restoration of the electrophysiological state of the retin

Use of L-arginine immobilised on activated carbon for pharmacological correction of endothelial disfunction

For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environmen

The northeastern Black Sea redox zone: Hydrochemical structure and its temporal variability

Detailed studies of the vertical structure of hydrochemical parameters in the northeastern Black Sea near Gelendzhik are presented and discussed. This work is based on a set of systematic observations carried out in this region during R/V Akvanavt and R/V Ashamba cruises from 1997 to 2005 and also on data from previous studies from 1984 to 1997. The Black Sea region near Gelendzhik is far from the influences of the Bosporus input and Danube River inflow. Therefore, the vertical structure in this region is more stable compared to the western Black Sea and reflects integrated, rather than local, changes of the Black Sea. Seasonal variations in the distribution of chemical parameters at the redox interface are connected to seasonal variations in hydrophysical processes and organic matter production. In winter, maxima of organic phosphorus and urea were absent in the vicinity of the onset of hydrogen sulfide. The concentrations of nitrate were lower in winter than in summer. Winter mixing in the anticyclone eddies led to reduced vertical gradients in the redox layer and to the disappearance of an upper phosphate minimum. Study of the interannual dynamics of oxygen concentrations in the Cold Intermediate Layer and anoxic waters boundary in the density field position revealed climatic-scale changes that may be connected with changes in the North Atlantic Oscillation (NAO) index. © 2006 Elsevier Ltd. All rights reserved