135 research outputs found
Investigating the Transition Region Explosive Events and Their Relationship to Network Jets
Recent imaging observations with the Interface Region Imaging Spectrograp
(IRIS) have revealed prevalent intermittent jets with apparent speeds of
80--250 km~s from the network lanes in the solar transition region (TR).
On the other hand, spectroscopic observations of the TR lines have revealed the
frequent presence of highly non-Gaussian line profiles with enhanced emission
at the line wings, often referred as explosive events (EEs). Using simultaneous
imaging and spectroscopic observations from IRIS, we investigate the
relationship between EEs and network jets. We first identify EEs from the
Si~{\sc{iv}}~1393.755 {\AA} line profiles in our observations, then examine
related features in the 1330 {\AA} slit-jaw images. Our analysis suggests that
EEs with double peaks or enhancements in both wings appear to be located at
either the footpoints of network jets, or transient compact brightenings. These
EEs are most likely produced by magnetic reconnection. We also find that EEs
with enhancements only at the blue wing are mainly located on network jets,
away from the footpoints. These EEs clearly result from the superposition of
the high-speed network jets on the TR background. In addition, EEs showing
enhancement only at the red wing of the line are often located around the jet
footpoints, possibly caused by the superposition of reconnection downflows on
the background emission. Moreover, we find some network jets that are not
associated with any detectable EEs. Our analysis suggests that some EEs are
related to the birth or propagation of network jets, and that others are not
connected to network jets.Comment: 9 figures; to appear in Ap
Magnetic reconnection at the earliest stage of solar flux emergence
On 2016 September 20, the Interface Region Imaging Spectrograph observed an
active region during its earliest emerging phase for almost 7 hours. The
Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory
observed continuous emergence of small-scale magnetic bipoles with a rate of
10 Mx~s. The emergence of magnetic fluxes and interactions
between different polarities lead to frequent occurrence of ultraviolet (UV)
bursts, which exhibit as intense transient brightenings in the 1400 \AA{}
images. In the meantime, discrete small patches with the same magnetic polarity
tend to move together and merge, leading to enhancement of the magnetic fields
and thus formation of pores (small sunspots) at some locations. The spectra of
these UV bursts are characterized by the superposition of several chromospheric
absorption lines on the greatly broadened profiles of some emission lines
formed at typical transition region temperatures, suggesting heating of the
local materials to a few tens of thousands of kelvin in the lower atmosphere by
magnetic reconnection. Some bursts reveal blue and red shifts of
100~km~s at neighboring pixels, indicating the spatially resolved
bidirectional reconnection outflows. Many such bursts appear to be associated
with the cancellation of magnetic fluxes with a rate of the order of
10 Mx~s. We also investigate the three-dimensional magnetic
field topology through a magneto-hydrostatic model and find that a small
fraction of the bursts are associated with bald patches (magnetic dips).
Finally, we find that almost all bursts are located in regions of large
squashing factor at the height of 1 Mm, reinforcing our conclusion that
these bursts are produced through reconnection in the lower atmosphere.Comment: ApJ, 10 figure
Two Solar Tornadoes Observed with the Interface Region Imaging Spectrograph
The barbs or legs of some prominences show an apparent motion of rotation,
which are often termed solar tornadoes. It is under debate whether the apparent
motion is a real rotating motion, or caused by oscillations or
counter-streaming flows. We present analysis results from spectroscopic
observations of two tornadoes by the Interface Region Imaging Spectrograph.
Each tornado was observed for more than 2.5 hours. Doppler velocities are
derived through a single Gaussian fit to the Mg~{\sc{ii}}~k~2796\AA{}~and
Si~{\sc{iv}}~1393\AA{}~line profiles. We find coherent and stable red and blue
shifts adjacent to each other across the tornado axes, which appears to favor
the interpretation of these tornadoes as rotating cool plasmas with
temperatures of K- K. This interpretation is further supported by
simultaneous observations of the Atmospheric Imaging Assembly on board the
Solar Dynamics Observatory, which reveal periodic motions of dark structures in
the tornadoes. Our results demonstrate that spectroscopic observations can
provide key information to disentangle different physical processes in solar
prominences.Comment: 14 figures, accepted by Ap
Functional characterization of breast cancer using pathway profiles
BACKGROUND: The molecular characteristics of human diseases are often represented by a list of genes termed “signature genes”. A significant challenge facing this approach is that of reproducibility: signatures developed on a set of patients may fail to perform well on different sets of patients. As diseases are resulted from perturbed cellular functions, irrespective of the particular genes that contribute to the function, it may be more appropriate to characterize diseases based on these perturbed cellular functions. METHODS: We proposed a profile-based approach to characterize a disease using a binary vector whose elements indicate whether a given function is perturbed based on the enrichment analysis of expression data between normal and tumor tissues. Using breast cancer and its four primary clinically relevant subtypes as examples, this approach is evaluated based on the reproducibility, accuracy and resolution of the resulting pathway profiles. RESULTS: Pathway profiles for breast cancer and its subtypes are constructed based on data obtained from microarray and RNA-Seq data sets provided by The Cancer Genome Atlas (TCGA), and an additional microarray data set provided by The European Genome-phenome Archive (EGA). An average reproducibility of 68% is achieved between different data sets (TCGA microarray vs. EGA microarray data) and 67% average reproducibility is achieved between different technologies (TCGA microarray vs. TCGA RNA-Seq data). Among the enriched pathways, 74% of them are known to be associated with breast cancer or other cancers. About 40% of the identified pathways are enriched in all four subtypes, with 4, 2, 4, and 7 pathways enriched only in luminal A, luminal B, triple-negative, and HER2+ subtypes, respectively. Comparison of profiles between subtypes, as well as other diseases, shows that luminal A and luminal B subtypes are more similar to the HER2+ subtype than to the triple-negative subtype, and subtypes of breast cancer are more likely to be closer to each other than to other diseases. CONCLUSIONS: Our results demonstrate that pathway profiles can successfully characterize both common and distinct functional characteristics of four subtypes of breast cancer and other related diseases, with acceptable reproducibility, high accuracy and reasonable resolution
A Magnetic Reconnection model for Hot Explosions in the Cool Atmosphere of the Sun
UV bursts and Ellerman bombs are transient brightenings observed in the low
solar atmospheres of emerging flux regions. Observations have discovered the
cospatial and cotemporal EBs and UV bursts, and their formation mechanisms are
still not clear. The multi-thermal components with a large temperature span in
these events challenge our understanding of magnetic reconnection and heating
mechanisms in the low solar atmosphere. We have studied magnetic reconnection
between the emerging and background magnetic fields. The initial plasma
parameters are based on the C7 atmosphere model. After the current sheet with
dense photosphere plasma is emerged to Mm above the solar surface,
plasmoid instability appears. The plasmoids collide and coalesce with each
other, which makes the plasmas with different densities and temperatures mixed
up in the turbulent reconnection region. Therefore, the hot plasmas
corresponding to the UV emissions and colder plasmas corresponding to the
emissions from other wavelenghts can move together and occur at about the same
height. In the meantime, the hot turbulent structures basically concentrate
above Mm, whereas the cool plasmas extend to much lower heights to the
bottom of the current sheet. These phenomena are consistent with the
observations of Chen et al. 2019, ApJL. The synthesized Si IV line profiles are
similar to the observed one in UV bursts, the enhanced wing of the line
profiles can extend to about km s. The differences are significant
among the numerical results with different resolutions, which indicate that the
realistic magnetic diffusivity is crucial to reveal the fine structures and
realistic plasmas heating in these reconnection events. Our results also show
that the reconnection heating contributed by ambipolar diffusion in the low
chromosphere around the temperature minimum region is not efficient
Flame-like Ellerman Bombs and Their Connection to Solar UV Bursts
Ellerman bombs (EBs) are small-scale intense brightenings in H wing
images, which are generally believed to be signatures of magnetic reconnection
events around the temperature minimum region of the solar atmosphere. They have
a flame-like morphology when observed near the solar limb. Recent observations
from the Interface Region Imaging Spectrograph (IRIS) reveal another type of
small-scale reconnection events, termed UV bursts, in the lower atmosphere.
Though previous observations have shown a clear coincidence of some UV bursts
and EBs, the exact relationship between these two phenomena is still under
debate. We investigate the spatial and temporal relationship between flame-like
EBs and UV bursts using joint near-limb observations between the 1.6--meter
Goode Solar Telescope (GST) and IRIS. In total 161 EBs have been identified
from the GST observations, and 20 of them reveal signatures of UV bursts in the
IRIS images. Interestingly, we find that these UV bursts have a tendency to
appear at the upper parts of their associated flame-like EBs. The intensity
variations of most EB-related UV bursts and their corresponding EBs match well.
Our results suggest that these UV bursts and EBs are likely formed at different
heights during a common reconnection process.Comment: 5 figures; accepted by ApJ
In vivo measurement of afferent activity with axon-specific calcium imaging.
In vivo calcium imaging from axons provides direct interrogation of afferent neural activity, informing the neural representations that a local circuit receives. Unlike in somata and dendrites, axonal recording of neural activity-both electrically and optically-has been difficult to achieve, thus preventing comprehensive understanding of neuronal circuit function. Here we developed an active transportation strategy to enrich GCaMP6, a genetically encoded calcium indicator, uniformly in axons with sufficient brightness, signal-to-noise ratio, and photostability to allow robust, structure-specific imaging of presynaptic activity in awake mice. Axon-targeted GCaMP6 enables frame-to-frame correlation for motion correction in axons and permits subcellular-resolution recording of axonal activity in previously inaccessible deep-brain areas. We used axon-targeted GCaMP6 to record layer-specific local afferents without contamination from somata or from intermingled dendrites in the cortex. We expect that axon-targeted GCaMP6 will facilitate new applications in investigating afferent signals relayed by genetically defined neuronal populations within and across specific brain regions
An Incremental Approach for Storage and Delivery Planning Problems
We consider a logistic planning problem for simultaneous optimization of the storage and the delivery. This problem arises in the consolidate shipment using an intermediate storage in a supply chain, which is typically found in the automobile industry. The vehicles deliver the items from the origin to the destination, while the items can be stored at some warehousing facilities as the intermediate storage during the delivery. The delivery plan is made for each day separately, but the storage at a warehouse may last for more than one day. Therefore, the entire logistic plan should be considered over a certain period for the total optimization. We formulate the storage and delivery problem as a mixed integer programming. Then, we propose a relax-and-fix type heuristic method, which incrementally fixes decision variables until all the variables are fixed to obtain a complete solution. Moreover, a semiapproximate model is introduced to effectively fix the variables. Based on the formulation, the delivery plan can be solved for each day separately. This has the advantage especially in the dynamic situation, where the delivery request is modified from the original request before the actual delivery day. Numerical experiments show that the simultaneous optimization gives the effective storage plan to reduce the total logistic cost, and the proposed heuristics efficiently reduce the computational time and are robust against the dynamic situation
Solar Ultraviolet Bursts in a Coordinated Observation of IRIS, Hinode and SDO
Solar ultraviolet (UV) bursts are small-scale compact brightenings in
transition region images. The spectral profiles of transition region lines in
these bursts are significantly enhanced and broadened, often with chromospheric
absorption lines such as Ni~{\sc{ii}} 1335.203 and 1393.330 {\AA} superimposed.
We investigate the properties of several UV bursts using a coordinated
observation of the Interface Region Imaging Spectrograph (IRIS), Solar Dynamics
Observatory (SDO), and \textit{Hinode} on 2015 February 7. We have identified
12 UV bursts, and 11 of them reveal small blueshifts of the Ni~{\sc{ii}}
absorption lines. However, the Ni~{\sc{ii}} lines in one UV burst exhibit
obvious redshifts of 20 km s, which appear to be related to the
cold plasma downflows observed in the IRIS slit-jaw images. We also examine the
three-dimensional magnetic field topology using a magnetohydrostatic model, and
find that some UV bursts are associated with magnetic null points or bald
patches. In addition, we find that these UV bursts reveal no obvious coronal
signatures from the observations of the Atmospheric Imaging Assembly (AIA) on
board SDO and the EUV Imaging Spectrometer (EIS) on board \textit{Hinode}.Comment: will appear in the journal of Science China Technological Science
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