Formation of the Galactic globular clusters with He-rich stars in low-mass halos virialized at high redshift

Recent observations have reported that the Galactic globular clusters (GCs) with unusually extended horizontal-branch (EHB) morphologies show a significantly lower velocity dispersion compared with that of the entire Galactic GC system. We consider that the observed distinctive kinematics of GCs with EHB has valuable information on the formation epochs of GCs and accordingly discuss this observational result based on cosmological N-body simulations with a model of GC formation. We assume that GCs in galaxies were initially formed in low-mass halos at high redshifts and we investigate final kinematics of GCs in their host halos at $z=0$. We find that GCs formed in halos virialized at z>10 show lower velocity dispersions on average than those formed at z>6 for halos with GCs at z=0. We thus suggest that the origin of the observed lower velocity dispersion for the Galactic GCs with EHBs is closely associated with earlier formation epochs (z>10) of halos initially hosting the GCs in the course of the Galaxy formation. Considering that the origin of EHBs can be due to the presence of helium-enhanced second-generation stars in GCs, we discuss the longstanding second parameter problem of GCs in the context of different degrees of chemical pollution in GC-forming gas clouds within low-mass halos virialized at different redshifts.Comment: 5 pages, 3 figures, accepted by MNRAS Letter

On the Origin of Mass--Metallicity Relations, Blue Tilts, and Scaling Relations for Metal-poor Globular Cluster Systems

We investigate formation processes and physical properties of globular cluster systems (GCSs) in galaxies based on high-resolution cosmological simulations with globular clusters. We focus on metal-poor clusters (MPCs) and correlations with their host galaxies by assuming that MPC formation is truncated at a high redshift (z_trun > 6). We find that the correlation between mean metallicities (Z_gc) of MPCs and their host galaxy luminosities (L) flattens from z=z_trun to z=0. We also find that the observed relation (Z_gc ~ L^0.15) in MPCs can be reproduced well in the models with Z_gc ~ L^0.5 at z=z_trun when z_trun ~ 10, if mass-to-light-ratios are assumed to be constant at z=z_trun. However, better agreement with the observed relation is found for models with different mass-to-light-ratios between z=z_trun and z=0. It is also found that the observed color-magnitude relation of luminous MPCs (i.e., ``blue tilts'') may only have a small contribution from the stripped stellar nuclei of dwarf galaxies, which have nuclei masses that correlate with their total mass at z=z_trun. The simulated blue tilts are found to be seen more clearly in more massive galaxies, which reflects the fact that more massive galaxies at z=0 are formed from a larger number of dwarfs with stellar nuclei formed at z>z_trun. The half-number radii (R_e) of GCSs, velocity dispersions of GCSs (sigma), and their host galaxy masses (M_h) are found to be correlated with one another such that R_e ~ M_h^{0.57} and sigma ~ M_h^{0.32}.Comment: 15 pages, 20 figures, accepted by MNRA

An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan

A 60-year old man with a 10-year history of multiple system atrophy (MSA) was found in respiratory arrest. After 4 months of respiratory support with two episodes of septic shock, he died. Autopsy disclosed severe atrophy of the mesencephalon, brainstem, medulla oblongata and cerebellum. Gallyas–Braak, α-synuclein and ubiquitin-positive inclusions in the cytoplasm of glial cells were evident, despite the severe ischaemic damage due to respiratory arrest and subsequent respiratory support for 4 months. The cause of respiratory arrest was not identified, but could be explained by the natural history of MSA. The bereaved family, who had suspected malpractice, was satisfied with the explanation based on the investigation performed by eight expert doctors, one expert nurse, two coordinator nurses and two lawyers in the model project promoted by the Japanese government

Dark energy constraints and correlations with systematics from CFHTLS weak lensing, SNLS supernovae Ia and WMAP5

We combine measurements of weak gravitational lensing from the CFHTLS-Wide survey, supernovae Ia from CFHT SNLS and CMB anisotropies from WMAP5 to obtain joint constraints on cosmological parameters, in particular, the dark energy equation of state parameter w. We assess the influence of systematics in the data on the results and look for possible correlations with cosmological parameters. We implement an MCMC algorithm to sample the parameter space of a flat CDM model with a dark-energy component of constant w. Systematics in the data are parametrised and included in the analysis. We determine the influence of photometric calibration of SNIa data on cosmological results by calculating the response of the distance modulus to photometric zero-point variations. The weak lensing data set is tested for anomalous field-to-field variations and a systematic shape measurement bias for high-z galaxies. Ignoring photometric uncertainties for SNLS biases cosmological parameters by at most 20% of the statistical errors, using supernovae only; the parameter uncertainties are underestimated by 10%. The weak lensing field-to-field variance pointings is 5%-15% higher than that predicted from N-body simulations. We find no bias of the lensing signal at high redshift, within the framework of a simple model. Assuming a systematic underestimation of the lensing signal at high redshift, the normalisation sigma_8 increases by up to 8%. Combining all three probes we obtain -0.10<1+w<0.06 at 68% confidence (-0.18<1+w<0.12 at 95%), including systematic errors. Systematics in the data increase the error bars by up to 35%; the best-fit values change by less than 0.15sigma. [Abridged]Comment: 14 pages, 10 figures. Revised version, matches the one to be published in A&A. Modifications have been made corresponding to the referee's suggestions, including reordering of some section

Numerical Galaxy Catalog -I. A Semi-analytic Model of Galaxy Formation with N-body simulations

We construct the Numerical Galaxy Catalog ($\nu$GC), based on a semi-analytic model of galaxy formation combined with high-resolution N-body simulations in a $\Lambda$-dominated flat cold dark matter ($\Lambda$CDM) cosmological model. The model includes several essential ingredients for galaxy formation, such as merging histories of dark halos directly taken from N-body simulations, radiative gas cooling, star formation, heating by supernova explosions (supernova feedback), mergers of galaxies, population synthesis, and extinction by internal dust and intervening HI clouds. As the first paper in a series using this model, we focus on basic photometric, structural and kinematical properties of galaxies at present and high redshifts. Two sets of model parameters are examined, strong and weak supernova feedback models, which are in good agreement with observational luminosity functions of local galaxies in a range of observational uncertainty. Both models agree well with many observations such as cold gas mass-to-stellar luminosity ratios of spiral galaxies, HI mass functions, galaxy sizes, faint galaxy number counts and photometric redshift distributions in optical pass-bands, isophotal angular sizes, and cosmic star formation rates. In particular, the strong supernova feedback model is in much better agreement with near-infrared (K'-band) faint galaxy number counts and redshift distribution than the weak feedback model and our previous semi-analytic models based on the extended Press-Schechter formalism. (Abridged)Comment: 26 pages including 27 figures, accepted for publication in ApJ, full-resolution version is available at http://grape.astron.s.u-tokyo.ac.jp/~yahagi/nugc

Revisiting the Cosmic Star Formation History: Caution on the Uncertainties in Dust Correction and Star Formation Rate Conversion

The cosmic star formation rate density (CSFRD) has been observationally investigated out to redshift z~10. However, most of theoretical models for galaxy formation underpredict the CSFRD at z>1. Since the theoretical models reproduce the observed luminosity functions (LFs), luminosity densities (LDs), and stellar mass density at each redshift, this inconsistency does not simply imply that theoretical models should incorporate some missing unknown physical processes in galaxy formation. Here, we examine the cause of this inconsistency in UV wavelengths by using a mock catalog of galaxies generated by a semi-analytic model of galaxy formation. We find that this inconsistency is due to two observational uncertainties: dust obscuration correction and conversion from UV luminosity to star formation rate (SFR). The methods for correction of obscuration and SFR conversion used in observational studies result in the overestimation of CSFRD by ~ 0.1-0.3 dex and ~ 0.1-0.2 dex, respectively, compared to the results obtained directly from our mock catalog. We present new empirical calibrations for dust attenuation and conversion from observed UV LFs and LDs into CSFRD.Comment: 12 pages including 11 figures. matches the published version (ApJ 2013 Jan. 20 issue

Acute Thrombogenicity of a Durable Polymer Everolimus-Eluting Stent Relative to Contemporary Drug-Eluting Stents With Biodegradable Polymer Coatings Assessed Ex Vivo in a Swine Shunt Model

AbstractObjectivesThis study sought to evaluate whether the permanent fluoropolymer-coated Xience Xpedition everolimus-eluting stent (Xience-EES) exhibits lower acute thrombogenicity compared with contemporary drug-eluting stents (DES) with biodegradable polymer coatings in an acute swine shunt model.BackgroundPrevious pre-clinical and clinical experience suggests that several factors may influence the predisposition for acute thrombus formation of polymer-coated DES, including stent design and the polymer coating technology. It remains unclear whether relevant differences exist with respect to acute thrombogenicity, particularly between current commercial stent designs using permanent polymers and those using biodegradable polymers.MethodsAn ex vivo carotid to jugular arteriovenous porcine shunt model involving a test circuit of 3 in-line stents, was used to test acute thrombogenicity, where Xience-EES (n = 24) was compared with 4 CE-marked DES with biodegradable polymer coatings (BioMatrix Flex, Synergy, Nobori, and Orsiro [n = 6 each]). After 1 h of circulation, platelet aggregation in whole mount stents was evaluated by confocal microscopy with immunofluorescent staining against dual platelet markers (CD61/CD42b) along with scanning electron microscopy.ResultsXience-EES showed the least percentage of thrombus-occupied area as compared with the biodegradable polymer-coated DES, with a significant difference compared with BioMatrix Flex and Synergy (mean differences: [BioMatrix Flex: 15.54, 95% confidence interval [CI]: 11.34 to 19.75, p < 0.001; Synergy: 8.64, 95% CI: 4.43 to 12.84, p < 0.001; Nobori: 4.22, 95% CI: -0.06 to 8.49, p = 0.055; Orsiro: 2.95, 95% CI: -1.26 to 7.15, p = 0.286). The number of cell nuclei on strut surfaces was also the least in Xience-EES, with a significant difference relative to BioMatrix Flex, Nobori, and Orsiro (mean ratios: BioMatrix Flex: 4.73, 95% CI: 2.46 to 9.08, p < 0.001; Synergy: 1.44, 95% CI: 0.75 to 2.76, p = 0.51; Nobori: 5.97, 95% CI: 3.11 to 11.44, p < 0.001; Orsiro: 5.16, 95% CI: 2.69 to 9.91, p < 0.001).ConclusionsXience-EES’s overall design confers acute thromboresistance relative to contemporary DES with biodegradable coatings, with less platelet aggregation versus BioMatrix Flex and Synergy, and less inflammatory cell attachment versus BioMatrix Flex, Nobori, and Orsiro, in an ex vivo swine shunt model, which lends support to reported clinical findings of lower early stent thrombosis

VLT photometry in the Antlia Cluster: the giant ellipticals NGC 3258 and NGC 3268 and their globular cluster systems

We present a deep VLT photometry in the regions surrounding the two dominant galaxies of the Antlia cluster, the giant ellipticals NGC 3258 and NGC 3268. We construct the luminosity functions of their globular cluster systems (GCSs) and determine their distances through the turn-over magnitudes. These distances are in good agreement with those obtained by the SBF method. There is some, but not conclusive, evidence that the distance to NGC 3268 is larger by several Mpc. The GCSs colour distributions are bimodal but the brightest globular clusters (GCs) show a unimodal distribution with an intermediate colour peak. The radial distributions of both GCSs are well fitted by de Vaucouleurs laws up to 5 arcmin. Red GCs present a steeper radial density profile than the blue GCs, and follow closely the galaxies' brightness profiles. Total GC populations are estimated to be about 6000+/-150 GCs in NGC 3258 and 4750+/-150 GCs in NGC 3268. We discuss the possible existence of GCs in a field located between the two giant galaxies (intracluster GCs). Their luminosity functions and number densities are consistent with the two GCSs overlapping in projection.Comment: 13 pages, 16 figures. Accepted for publication in MNRA

Usefulness and safety of 0.4% sodium hyaluronate solution as a submucosal fluid "cushion" for endoscopic resection of colorectal mucosal neoplasms: A prospective multi-center open-label trial

<p>Abstract</p> <p>Background</p> <p>Sodium hyaluronate (SH) solution has been used for submucosal injection in endoscopic resection to create a long-lasting submucosal fluid "cushion". Recently, we proved the usefulness and safety of 0.4% SH solution in endoscopic resection for gastric mucosal tumors. To evaluate the usefulness of 0.4% SH as a submucosal injection solution for colorectal endoscopic resection, we conducted an open-label clinical trial on six referral hospitals in Japan.</p> <p>Methods</p> <p>A prospective multi-center open-label study was designed. A total of 41 patients with 5–20 mm neoplastic lesions localized in the colorectal mucosa at six referral hospitals in Japan in a single year period from December 2002 to November 2003 were enrolled and underwent endoscopic resection with SH. The usefulness of 0.4% SH was assessed by the <it>en bloc </it>complete resection and the formation and maintenance of mucosal lesion-lifting during endoscopic resection. Safety was evaluated by analyzing adverse events during the study period.</p> <p>Results</p> <p>The usefulness rate was high (82.5%; 33/40). The following secondary outcome measures were noted: 1) steepness of mucosal lesion-lifting, 75.0% (30/40); 2) intraoperative complications, 10.0% (4/40); 3) time required for mucosal resection, 6.7 min; 4) volume of submucosal injection, 6.8 mL and 5) ease of mucosal resection, 87.5% (35/40). Two adverse events of bleeding potentially related to 0.4% SH were reported.</p> <p>Conclusion</p> <p>Using 0.4% SH solution enabled sufficient lifting of a colorectal intramucosal lesion during endoscopic resection, reducing the need for additional injections and the risk of perforation. Therefore, 0.4% SH may contribute to the reduction of complications and serve as a promising submucosal injection solution due to its potentially superior safety in comparison to normal saline solution.</p