White matter T2 hyperintensities and blood‐brain barrier disruption in the hyperacute stage of subarachnoid hemorrhage in male mice: The role of lipocalin‐2

AimsThe current study examined whether white matter injury occurs in the hyperacute (4 hours) phase after subarachnoid hemorrhage (SAH) and the potential role of blood‐brain barrier (BBB) disruption and an acute phase protein, lipocalin 2 (LCN2), in that injury.MethodsSubarachnoid hemorrhage was induced by endovascular perforation in adult mice. First, wild‐type (WT) mice underwent MRI 4 hours after SAH to detect white matter T2 hyperintensities. Second, changes in LCN2 expression and BBB disruption associated with the MRI findings were examined. Third, SAH‐induced white matter injury at 4 hours was compared in WT and LCN2 knockout (LCN2 KO) mice.ResultsAt 4 hours, most animals had uni‐ or bilateral white matter T2 hyperintensities after SAH in WT mice that were associated with BBB disruption and LCN2 upregulation. However, some disruption and LCN2 upregulation was also found in mice with no T2‐hyperintensity lesion. In contrast, there were no white matter T2 hyperintensities in LCN2 KO mice after SAH. LCN2 deficiency also attenuated BBB disruption, myelin damage, and oligodendrocyte loss.ConclusionsSubarachnoid hemorrhage causes very early BBB disruption and LCN2 expression in white matter that is associated with and may precede T2 hyperintensities. LCN2 deletion attenuates MRI changes and pathological changes in white matter after SAH.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151855/1/cns13221.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151855/2/cns13221_am.pd

Ba-enhanced dwarf and subgiant stars in the LAMOST Galactic surveys

Ba-enhanced stars are interesting probes of stellar astrophysics and Galactic formation history. In this work, we investigate the chemistry and kinematics for a large sample of Ba-enhanced ([Ba/Fe]$>$1.0) dwarf and subgiant stars with $5000 < T_{\rm eff }< 6700$\,K from LAMOST. We find that both stellar internal evolution process and external mass exchange due to binary evolution are responsible for the origins of the Ba-enhancement of our sample stars. About one third of them exhibit C and N enhancement and ultraviolet brightness excess, indicating they are products of binary evolution. The remaining Ba-enhanced stars with normal C and N abundances are mostly warm stars with $T_{\rm eff} > 6000$\,K. They are likely consequences of stellar internal elemental transport processes, but they show very different elemental patterns to the hotter Am/Fm stars. Our results reveal a substantially lack of high-[$\alpha$/Fe] Ba-enhanced stars in the [Fe/H]--[$\alpha$/Fe] plane, which we dub as a {\em high-$\alpha$ desert}. We suggest it is due to a lower efficiency for producing Ba-enhanced stars by low-mass AGB progenitors in binary systems. Our results call for detailed modellings for these Ba-enhanced stellar peculiars, in the context of both stellar internal elemental transport and external mass accretion.Comment: 20 pages, 17 figures. Accepted for publication in Ap

On Antiproton Production in 158 GeV/ c

The multisource thermal model is used in this paper to analyze the antiproton (p¯) production process in high-energy proton-carbon (p-C) collisions. The transverse momentum, Feynman variable, and rapidity distributions of antiprotons in the nucleon-nucleon center-of-mass system are calculated by using the model. The modeling results are compared and found to be in agreement with the experimental data measured by the NA49 Collaboration at 158 GeV/c beam momentum. As a parameter, the nuclear temperature of interacting system extracted from the antiproton spectrum is estimated to be about 150 MeV

Effect of rosiglitazone on rabbit model of myocardial ischemia-reperfusion injury

AbstractObjectiveTo explore mechanism and protective effect of rosiglitazone on myocardial ischemia reperfusion (I/R) injury.MethodsA total of 48 male Japanese white big-ear rabbits were randomly divided into control group (A), I/R group (B), low dose of rosiglitazone group (C), high dose of rosiglitazone group (D). Plasma concentration of and also reduced the concentration of plasma serum creatine kinase (CK), CK-MB, high-sensitivity C-reactive protein (hsCRP), ultra-superoxide dismutase (SOD), malondialdehyde (MDA), lactic acid glutathione skin peroxidase (GSH-PX), nitric oxide (NO) and endothelin (ET) were measured 1 h later after I/R. Twenty-four hours after I/R the hearts were harvested for pathological and ultrastructural analysis. Area of myocardial infarction were tested.ResultsPlasma concentration of CK, CK-MB, hsCRP, NO, MDA and ET were decreased in C, D group compared with group B. Plasma concentration of T-SOD and GSH-Px were increased significantly in C, D group compared with group B. Compared with group B, pathological and ultrastructural changes in C and D group were slightly. There was significant difference in myocardial infarction area between group C, D and group B (P<0.05). Myocardial infarction area and arrhythmia rate were lower in group C, D compare with group B.ConclusionsRosiglitazone may protect myocardium from I/R injury by enhancing T-SOD and GSH-Px concentration, inhibit inflammatory reaction, and improve endothelial function

2-(o-Tol­yloxy)benzoic acid

In the crystal structure of the title compound, C14H12O3, mol­ecules are linked via inter­molecular O—H⋯O hydrogen bonds, resulting in dimer formation. The dihedral angle between the two phenyl rings is 76.2 (2)°

Variability of the giant X-ray bump in GRB 121027A and possible origin

The particular giant X-ray bump of GRB 121027A triggered by \emph{Swift} is quite different from the typical X-ray flares in gamma-ray bursts. There exhibit four parts of the observed structural variabilities in the rise and decay phase of the bump. Considering the quality of four parts of the data, we can only analyze the data from about 5300 s to about 6100 s in the bump using the stepwise filter correlation method (Gao et al. 2012), and find that the $86^{+5.9}_{-9.4}~\rm s$ periodic oscillation may exist, which is confirmed by the Lomb-Scargle method (Scargle 1982). Furthermore, a jet precession model (Liu et al. 2010) is proposed to account for such a variability.Comment: 5 pages, 3 figures, accepted for publication in MNRA