10 research outputs found
Peptide ligations accelerated by N-terminal aspartate and glutamate residues
A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated. © 2011 American Chemical Society