10 research outputs found

    Peptide ligations accelerated by N-terminal aspartate and glutamate residues

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    A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated. © 2011 American Chemical Society

    Chemistry, bioactivity and quality control of Dendrobium, a commonly used tonic herb in traditional Chinese medicine

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