Inuvialuit Living Art: Co-Creating Local Community Archaeology and Cultural Heritage Research

This thesis explores Inuvialuit cultural heritage through the lens of Inuvialuit Pitqusiat Inuusimitkun or living art, a term coined by Iñupiaq/Inuvialuk Elder Pauline Saturgina Tardiff and translated to Sallirmiutun by Inuvialuit Elders Albert and Shirley Elias. Using semi-structured interviews, focus groups, and ethnography, it brings together the knowledge of 11 Inuvialuit artists to discuss Inuvialuit living art through: its ability to tell stories through time and space; its role in surviving and thriving on the land; and its connection to inner “heartwork”. Using a community-based participatory research (CBPR) framework, it outlines the 2019 Inuvialuit Living History Culture Camp at Ivvavik National Park, where living art, photovoice, and participatory design were employed in action with nine Inuvialuit research partners to co-create visual products and documentation of Inuvialuit cultural heritage. This thesis concludes that living art is a vital aspect of Inuvialuit cultural heritage and advocates for continued engagements with living art, musicality, and a heart-centred approach in the future of archaeological research

The role of phagocytic respiratory burst in host defense against Mycobacterium tuberculosis

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PR prolongation strongly predicts new-onset myocardial infarction, ischaemic stroke, heart failure, and cardiovascular death in coronary patients or risk equivalent: a 5-year clinical-patholophysiological study

Oral PresentationOBJECTIVES: To investigate the role of PR prolongation in new-onset adverse cardiovascular (CV) events in high-risk CV patients, and the underlying pathophysiological mechanisms in terms of vascular phenotypes. METHODS: We prospectively followed up 597 high-risk CV out-patients (mean age 66±11 years; male 67%; coronary disease 55%, stroke 22%, diabetes 52%) for new-onset ischaemic stroke, myocardial infarction (MI), congestive heart failure (CHF), and CV death. Vascular phenotypes were asses…published_or_final_versio

Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression

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Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosis

This is a retrospective analysis of 4768 patients with undifferentiated or non-keratinising carcinoma of the nasopharynx who were treated during 1 January 1976 to 31 December 1985. The mean duration of symptoms before diagnosis was 8 months (range, 1-36 months for 95% of patients). A significant association between the duration of symptoms and the presenting stage was observed (P<0.001); 58% and 39% of stage I and stage V patients, respectively, reported as having had symptoms for less than 6 months. Of the later presenters (those having had symptoms for 6 months or longer), 89% were given a full course of radical megavoltage radiotherapy, but 6% were too advanced for any irradiation attempt. Consequently, the 10-year actuarial disease-specific survival was significantly higher among the early presenters: 48% versus 42% (P<0.001). The importance of early detection is emphasised.published_or_final_versio

Cp∗Rh(III)-catalyzed electrophilic amination of arylboronic acids with azo compounds for synthesis of arylhydrazides

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Maintaining Well-Being During the COVID-19 Pandemic: A Network Analysis of Well-Being Responses from British Youth

COVID-19 has significant impacts on young peoples’ lives and emotions. Understanding how young people maintain well-being in the face of challenges can inform future mental health intervention development. Here we applied network analysis to well-being data gathered from 2532 young people (12-25 years) residing in the UK during the COVID-19 pandemic to identify the structure across well-being and crucially, its central defining features. Gender and age differences in networks were also investigated. Across all participants, items emerged in two clusters: 1) optimism, positive self-perception, and social connectedness, and 2) processing problems and ideas. The two central features of well-being were: “I’ve been dealing with problems well” and “I’ve been thinking clearly”. There were minimal age and gender differences. Our findings suggest that the perception of being able to process problems and ideas efficiently could be a hallmark of well-being, particularly in the face of challenging circumstances. These findings contrast with pre-pandemic studies that point to positive affect as central aspects of well-being networks. Future interventions that encourage problem-solving and mental flexibility could be useful in helping young people maintain well-being during times of stress and uncertainty

Physicians Infrequently Adhere to Hepatitis Vaccination Guidelines for Chronic Liver Disease

Background and Goals:Hepatitis A (HAV) and hepatitis B (HBV) vaccination in patients with chronic liver disease is an accepted standard of care. We determined HAV and HBV vaccination rates in a tertiary care referral hepatology clinic and the impact of electronic health record (EHR)-based reminders on adherence to vaccination guidelines.Methods:We reviewed the records of 705 patients with chronic liver disease referred to our liver clinic in 2008 with at least two follow-up visits during the subsequent year. Demographics, referral source, etiology, and hepatitis serology were recorded. We determined whether eligible patients were offered vaccination and whether patients received vaccination. Barriers to vaccination were determined by a follow-up telephone interview.Results:HAV and HBV serologic testing prior to referral and at the liver clinic were performed in 14.5% and 17.7%; and 76.7% and 74% patients, respectively. Hepatologists recommended vaccination for HAV in 63% and for HBV in 59.7% of eligible patients. Patient demographics or disease etiology did not influence recommendation rates. Significant variability was observed in vaccination recommendation amongst individual providers (30-98.6%), which did not correlate with the number of patients seen by each physician. Vaccination recommendation rates were not different for Medicare patients with hepatitis C infection for whom a vaccination reminder was automatically generated by the EHR. Most patients who failed to get vaccination after recommendation offered no specific reason for noncompliance; insurance was a barrier in a minority.Conclusions:Hepatitis vaccination rates were suboptimal even in an academic, sub-speciality setting, with wide-variability in provider adherence to vaccination guidelines. © 2013 Thudi et al

TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells

BACKGROUND: TSPY is a repeated gene mapped to the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY), the only oncogenic locus on this male-specific chromosome. Elevated levels of TSPY have been observed in gonadoblastoma specimens and a variety of other tumor tissues, including testicular germ cell tumors, prostate cancer, melanoma, and liver cancer. TSPY contains a SET/NAP domain that is present in a family of cyclin B and/or histone binding proteins represented by the oncoprotein SET and the nucleosome assembly protein 1 (NAP1), involved in cell cycle regulation and replication. METHODS: To determine a possible cellular function for TSPY, we manipulated the TSPY expression in HeLa and NIH3T3 cells using the Tet-off system. Cell proliferation, colony formation assays and tumor growth in nude mice were utilized to determine the TSPY effects on cell growth and tumorigenesis. Cell cycle analysis and cell synchronization techniques were used to determine cell cycle profiles. Microarray and RT-PCR were used to investigate gene expression in TSPY expressing cells. RESULTS: Our findings suggest that TSPY expression increases cell proliferation in vitro and tumorigenesis in vivo. Ectopic expression of TSPY results in a smaller population of the host cells in the G(2)/M phase of the cell cycle. Using cell synchronization techniques, we show that TSPY is capable of mediating a rapid transition of the cells through the G(2)/M phase. Microarray analysis demonstrates that numerous genes involved in the cell cycle and apoptosis are affected by TSPY expression in the HeLa cells. CONCLUSION: These data, taken together, have provided important insights on the probable functions of TSPY in cell cycle progression, cell proliferation, and tumorigenesis