785 research outputs found
Role of the Brans-Dicke scalar in the holographic description of dark energy
We study cosmological application of the holographic energy density in the
Brans-Dicke theory. Considering the holographic energy density as a dynamical
cosmological constant, it is more natural to study it in the Brans-Dicke theory
than in general relativity. Solving the Friedmann and Brans-Dicke field
equations numerically, we clarify the role of Brans-Dicke field during
evolution of the universe. When the Hubble horizon is taken as the IR cutoff,
the equation of state (w_{\Lmd}) for the holographic energy density is
determined to be 5/3 when the Brans-Dicke parameter \omg goes infinity. This
means that the Brans-Dicke field plays a crucial role in determining the
equation of state. For the particle horizon IR cutoff, the Brans-Dicke scalar
mediates a transition from w_{\Lmd} = -1/3 (past) to w_{\Lmd} = 1/3
(future). If a dust matter is present, it determines future equation of state.
In the case of future event horizon cutoff, the role of the Brans-Dicke scalar
and dust matter are turned out to be trivial, whereas the holographic energy
density plays an important role as a dark energy candidate with w_{\Lmd} =-1.Comment: 10pages, 3figures, version to appear in PL
Fast simultaneous detection of K-RAS mutations in colorectal cancer
<p>Abstract</p> <p>Background</p> <p><it>RAS </it>genes acquire the most common somatic gain-of-function mutations in human cancer, and almost all of these mutations are located at codons 12, 13, 61, and 146.</p> <p>Methods</p> <p>We present a method for detecting these <it>K-RAS </it>hotspot mutations in 228 cases of colorectal cancer. The protocol is based on the multiplex amplification of exons 2, 3 and 4 in a single tube, followed by primer extension of the PCR products using various sizes of primers to detect base changes at codons 12, 13, 61 and 146. We compared the clinicopathological data of colorectal cancer patients with the <it>K-RAS </it>mutation status.</p> <p>Results</p> <p><it>K-RAS </it>mutation occurred in 36% (83/228) of our colorectal cancer cases. Univariate analysis revealed a significant association between <it>K-RAS </it>mutation at codon 12 of exon 2 and poor 5-year survival (p = 0.023) and lymph node involvement (p = 0.048). Also, <it>K-RAS </it>mutation at codon 13 of exon 2 correlates with the size of the tumor (p = 0.03). Multivariate analysis adjusted for tumor size, histologic grade, and lymph node metastasis also indicated <it>K-RAS </it>mutations at codon 12 and 13 of exon 2 correlate significantly with overall survival (p = 0.002 and 0.025). No association was observed between codon 61 and 146 and clinicopathological features.</p> <p>Conclusion</p> <p>We demonstrated a simple and fast way to identify <it>K-RAS </it>mutation.</p
Three-dimensional flux states as a model for the pseudogap phase of transition metal oxides
We propose that the pseudogap state observed in the transition metal oxides
can be explained by a three-dimensional flux state, which exhibits
spontaneously generated currents in its ground state due to electron-electron
correlations. We compare the energy of the flux state to other classes of mean
field states, and find that it is stabilized over a wide range of and
. The signature of the state will be peaks in the neutron diffraction
spectra, the location and intensity of which are presented. The dependence of
the pseudogap in the optical conductivity is calculated based on the parameters
in the model.Comment: submitted to Phys. Rev. B on January 8, 200
Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques
Coronary computed tomography angiography (CCTA) is a widely used imaging modality for diagnosing coronary artery disease (CAD) but is limited by a high false positive rate when evaluating coronary arteries with stents and heavy calcifications. Virtual intravascular endoscopy (VIE) images generated from CCTA can be used to qualitatively assess the vascular lumen and might be helpful for overcoming this challenge. In this study, one hundred subjects with coronary stents underwent both CCTA and invasive coronary angiography (ICA). A total of 902 vessel segments were analyzed using CCTA and VIE. The vessel segments were first analyzed on CCTA alone. Then, using VIE, the segments were classified qualitatively as either negative or positive for in-stent restenosis (ISR) or CAD. These results were compared, using ICA as the reference, to determine the added diagnostic value of VIE. Of the 902 analyzed vessel segments, CCTA/VIE had sensitivity, specificity, accuracy, positive predictive value, and negative predictive value (shown in %) of 93.9/90.2, 96.2/98.2, 96.0/97.7, 70.0/83.1, and 99.4/99.0, respectively, in diagnosing ISR or CAD, with significantly improved specificity (p = 0.025), accuracy (p = 0.046), and positive predictive value (p = 0.047). VIE can be a helpful addition to CCTA when evaluating coronary arterie
Stepwise formation of heteronuclear coordination networks based on quadruple-bonded dimolybdenum units containing formamidinate ligands
Reactions of [Mo2(4-pyf)4] (4-Hpyf = 4-pyridylformamidine) with
HgX2 (X = Cl, Br and I) afforded the first 2D and 3D heteronuclear
coordination networks based on quadruple-bonded dimolybdenum
units
Interacting Agegraphic Dark Energy
A new dark energy model, named "agegraphic dark energy", has been proposed
recently, based on the so-called K\'{a}rolyh\'{a}zy uncertainty relation, which
arises from quantum mechanics together with general relativity. In this note,
we extend the original agegraphic dark energy model by including the
interaction between agegraphic dark energy and pressureless (dark) matter. In
the interacting agegraphic dark energy model, there are many interesting
features different from the original agegraphic dark energy model and
holographic dark energy model. The similarity and difference between agegraphic
dark energy and holographic dark energy are also discussed.Comment: 10 pages, 5 figures, revtex4; v2: references added; v3: accepted by
Eur. Phys. J. C; v4: published versio
Interacting entropy-corrected new agegraphic tachyon, K-essence and dilaton scalar field models of dark energy in non-flat universe
We present the new agegraphic dark energy model by introducing the quantum
corrections to the entropy-area relation in the setup of loop quantum gravity.
Employing this new form of dark energy, we investigate the model of interacting
dark energy and derive its equation of state. We study the correspondence
between the tachyon, K-essence and dilaton scalar field models with the
interacting entropy-corrected new agegraphic dark energy model in the non-flat
FRW universe. Moreover, we reconstruct the corresponding scalar potentials
which describe the dynamics of the scalar field models.Comment: 11 pages, typos fixe
Interacting Holographic dark energy in chameleon tachyon cosmology
We propose in this paper an interacting holographic dark energy (IHDE) model
in chameleon--tachyon cosmology by interaction between the components of the
dark sectors. In the formalism, the interaction term emerges from the scalar
field coupling matter lagrangian in the model rather than being inserted into
the formalism as an external source for the interaction. The correspondence
between the tachyon field and the holographic dark energy (HDE) densities
allows to reconstruct the tachyon scalar field and its potential in a flat FRW
universe. The model can show the accelerated expansion of the universe and
satisfies the observational data.Comment: 12 pages, 12 figures; will be published in Astrophys. Space Sc
Interacting entropy-corrected new agegraphic dark energy in Brans-Dicke cosmology
Motivated by a recent work of one of us [1], we extend it by using quantum
(or entropy) corrected new agegraphic dark energy in the Brans-Dicke cosmology.
The correction terms are motivated from the loop quantum gravity which is one
of the competitive theories of quantum gravity. Taking the non-flat background
spacetime along with the conformal age of the universe as the length scale, we
derive the dynamical equation of state of dark energy and the deceleration
parameter. An important consequence of this study is the phantom divide
scenario with entropy-corrected new agegraphic dark energy. Moreover, we assume
a system of dark matter, radiation and dark energy, while the later interacts
only with dark matter. We obtain some essential expressions related with dark
energy dynamics. The cosmic coincidence problem is also resolved in our model.Comment: 16 pages, no figure, accepted for publication in Gen. Relativ. Gra
Observation of a Narrow Resonance of Mass 2.46 GeV/c^2 Decaying to D_s^*+ pi^0 and Confirmation of the D_sJ^* (2317) State
Using 13.5 inverse fb of e+e- annihilation data collected with the CLEO II
detector we have observed a narrow resonance in the Ds*+pi0 final state, with a
mass near 2.46 GeV. The search for such a state was motivated by the recent
discovery by the BaBar Collaboration of a narrow state at 2.32 GeV, the
DsJ*(2317)+ that decays to Ds+pi0. Reconstructing the Ds+pi0 and Ds*+pi0 final
states in CLEO data, we observe peaks in both of the corresponding
reconstructed mass difference distributions, dM(Dspi0)=M(Dspi0)-M(Ds) and
dM(Ds*pi0)=M(Ds*pi0)-M(Ds*), both of them at values near 350 MeV. We interpret
these peaks as signatures of two distinct states, the DsJ*(2317)+ plus a new
state, designated as the DsJ(2463)+. Because of the similar dM values, each of
these states represents a source of background for the other if photons are
lost, ignored or added. A quantitative accounting of these reflections confirms
that both states exist. We have measured the mean mass differences
= 350.0 +/- 1.2 [stat] +/- 1.0 [syst] MeV for the DsJ*(2317) state, and
= 351.2 +/- 1.7 [stat] +/- 1.0 [syst] MeV for the new DsJ(2463)+
state. We have also searched, but find no evidence, for decays of the two
states via the channels Ds*+gamma, Ds+gamma, and Ds+pi+pi-. The observations of
the two states at 2.32 and 2.46 GeV, in the Ds+pi0 and Ds*+pi0 decay channels
respectively, are consistent with their interpretations as (c anti-strange)
mesons with orbital angular momentum L=1, and spin-parities of 0+ and 1+.Comment: 16 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, version to be published in Physical
Review D; minor modifications and fixes to typographical errors, plus an
added section on production properties. The main results are unchanged; they
supersede those reported in hep-ex/030501
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