Do men consult less than women? An analysis of routinely collected UK general practice data

<p>Objective To examine whether gender differences in primary care consultation rates (1) vary by age and deprivation status and (2) diminish when consultation for reproductive reasons or common underlying morbidities are accounted for.</p> <p>Design Cross-sectional study of a cohort of patients registered with general practice.</p> <p>Setting UK primary care.</p> <p>Subjects Patients (1 869 149 men and 1 916 898 women) registered with 446 eligible practices in 2010.</p> <p>Primary outcome measures Primary care consultation rate.</p> <p>Results This study analyses routinely collected primary care consultation data. The crude consultation rate was 32% lower in men than women. The magnitude of gender difference varied across the life course, and there was no ‘excess’ female consulting in early and later life. The greatest gender gap in primary care consultations was seen among those aged between 16 and 60 years. Gender differences in consulting were higher in people from more deprived areas than among those from more affluent areas. Accounting for reproductive-related consultations diminished but did not eradicate the gender gap. However, consultation rates in men and women who had comparable underlying morbidities (as assessed by receipt of medication) were similar; men in receipt of antidepressant medication were only 8% less likely to consult than women in receipt of antidepressant medication (relative risk (RR) 0.916, 95% CI 0.913 to 0.918), and men in receipt of medication to treat cardiovascular disease were just 5% less likely to consult (RR=0.950, 95% CI 0.948 to 0.952) than women receiving similar medication. These small gender differences diminished further, particularly for depression (RR=0.950, 95% CI 0.947 to 0.953), after also taking account of reproductive consultations.</p> <p>Conclusions Overall gender differences in consulting are most marked between the ages of 16 and 60 years; these differences are only partially accounted for by consultations for reproductive reasons. Differences in consultation rates between men and women were largely eradicated when comparing men and women in receipt of medication for similar underlying morbidities.</p&gt

Dynamical Electron Mass in a Strong Magnetic Field

Motivated by recent interest in understanding properties of strongly magnetized matter, we study the dynamical electron mass generated through approximate chiral symmetry breaking in QED in a strong magnetic field. We reliably calculate the dynamical electron mass by numerically solving the nonperturbative Schwinger-Dyson equations in a consistent truncation within the lowest Landau level approximation. It is shown that the generation of dynamical electron mass in a strong magnetic field is significantly enhanced by the perturbative electron mass that explicitly breaks chiral symmetry in the absence of a magnetic field.Comment: 5 pages, 1 figure, published versio

Identification of a novel TSC2 c.3610G > A, p.G1204R mutation contribute to aberrant splicing in a patient with classical tuberous sclerosis complex: a case report

Background: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in any organ systems. Mutations in the TSC1 or TSC2 gene lead to the dysfunction of hamartin or tuberin proteins, which cause tuberous sclerosis complex. Case presentation: We describe the clinical characteristics of patients from a Chinese family with tuberous sclerosis complex and analyze the functional consequences of their causal genetic mutations. A novel heterozygous mutation (c.3610G > A) at the last nucleotide of exon 29 in TSC2 was identified. On the protein level, this variant was presumed to be a missense mutation (p.Gly1204Arg). However, the splicing assay revealed that this mutation also leads to the whole TSC2 exon 29 skipping, besides the wild-type transcript. The mutated transcript results in an in-frame deletion of 71 amino acids (p.Gly1133_Thr1203del) and its ratio with the normal splice product is of about 44:56. Conclusions: The novel c.3610G > A TSC2 mutation was identified in association with tuberous sclerosis complex. And it was proven to code both for a missense-carrying transcript (56%), and for an isoform lacking exon 29 (44%)

Control of spin coherence in semiconductor double quantum dots

We propose a scheme to manipulate the spin coherence in vertically coupled GaAs double quantum dots. Up to {\em ten} orders of magnitude variation of the spin relaxation and {\em two} orders of magnitude variation of the spin dephasing can be achieved by a small gate voltage applied vertically on the double dot. Specially, large variation of spin relaxation still exists at 0 K. In the calculation, the equation-of-motion approach is applied to obtain the electron decoherence time and all the relevant spin decoherence mechanisms, such as the spin-orbit coupling together with the electron--bulk-phonon scattering, the direct spin-phonon coupling due to the phonon-induced strain, the hyperfine interaction and the second-order process of electron-phonon scattering combined with the hyperfine interaction, are included. The condition to obtain the large variations of spin coherence is also addressed.Comment: 6 pages, 4 figures, to be published in PR

Robust half-metallic antiferromagnets LaAAVOsO6_6 and LaAAMoYYO6_6 (AA = Ca, Sr, Ba; YY = Re, Tc) from first-principles calculations

We have theoretically designed three families of the half-metallic (HM) antiferromagnets (AFM), namely, La$A$VOsO$_6$, La$A$MoTcO$_6$ and La$A$MoReO$_6$ ($A$ = Ca, Sr, Ba), based on a systematic {\it ab initio} study of the ordered double perovskites La$ABB'$O$_6$ with the possible $B$ and $B'$ pairs from all the 3$d$, 4$d$ and 5$d$ transtion metal elements being considered. Electronic structure calculations based on first-principles density-functional theory with generalized gradient approximation (GGA) for more than sixty double perovskites LaCa$BB'$O$_6$ have been performed using the all-electron full-potential linearized augmented-plane-wave method. The found HM-AFM state in these materials survives the full {\it ab initio} lattice constant and atomic position optimizations which were carried out using frozen-core full potential projector augmented wave method. It is found that the HM-AFM properties predicted previously in some of the double perovskites would disappear after the full structural optimizations. The AFM is attributed to both the superexchange mechanism and the generalized double exchange mechanism via the $B$ ($t_{2g}$) - O (2$p_{\pi}$) - $B'$ ($t_{2g}$) coupling and the latter is also believed to be the origin of the HM. Finally, in our search for the HM-AFMs, we find La$A$CrTcO$_6$ and La$A$CrReO$_6$ to be AFM insulators of an unconventional type in the sense that the two antiferromagnetic coupled ions consist of two different elements and that the two spin-resolved densities of states are no longer the same.Comment: To appear in Phys. Rev.

Anisotropy of the upper critical fields and the paramagnetic Meissner effect in La1.85Sr0.15CuO4 single Crystals

Optimally-doped La1.85Sr0.15CuO4 single crystals have been investigated by dc and ac magnetic measurements. These crystals have rectangular needle-like shapes with the long needle axis parallel to the crystallographic c axis (c-crystal) or parallel to the basal planes (a-crystal). In both crystals, the temperature dependence of the upper critical fields (HC2) and the surface critical field (HC3) were measured. The H-T phase diagram is presented. Close to TC =35 K, for the c-crystal, {\gamma}c = / = 1.80(2), whereas for the a-crystal the {\gamma}a = / =4.0(2) obtained, is much higher than the theoretical value 1.69. At low applied dc fields, positive field-cooled branches known as the "paramagnetic Meissner effect" (PME) are observed, their magnitude is inversely proportional to H. The anisotropic PME is observed in both a- and c-crystals, only when the applied field is along the basal planes. It is speculated that the high {\gamma}a and the PME are connected to each other.Comment: 10 pages, 7 figuer

Disk Accretion onto Magnetized Neutron Stars: The Inner Disk Radius and Fastness Parameter

It is well known that the accretion disk around a magnetized compact star can penetrate inside the magnetospheric boundary, so the magnetospheric radius \ro does not represent the true inner edge \rin of the disk; but controversies exist in the literature concerning the relation between \ro and \rin. In the model of Ghosh & Lamb, the width of the boundary layer is given by \delta=\ro-\rin\ll\ro, or \rin\simeq\ro, while Li & Wickramasinghe recently argued that \rin could be significantly smaller than \ro in the case of a slow rotator. Here we show that if the star is able to absorb the angular momentum of disk plasma at \ro, appropriate for binary X-ray pulsars, the inner disk radius can be constrained by 0.8\lsim \rin/\ro\lsim 1, and the star reaches spin equilibrium with a relatively large value of the fastness parameter ($\sim 0.7-0.95$). For accreting neutron stars in low-mass X-ray binaries (LMXBs), \ro is generally close to the stellar radius \rs so that the toroidal field cannot transfer the spin-up torque efficiently to the star. In this case the critical fastness parameter becomes smaller, but \rin is still near \ro.Comment: 7 pages, 2 figures, to appear in Ap

An Infrared study of the Josephson vortex state in high-Tc cuprates

We report the results of the c-axis infrared spectroscopy of La_{2-x} Sr_x CuO_4 in high magnetic field oriented parallel to the CuO_2 planes. A significant suppression of the superfluid density with magnetic field rho_s(H) is observed for both underdoped (x=0.125) and overdoped (x=0.17) samples. We show that the existing theoretical models of the Josephson vortex state fail to consistently describe the observed effects and discuss possible reasons for the discrepancies