Heavy-meson physics and flavour violation with a single generation

We study flavour-violating processes which involve heavy B- and D-mesons and are mediated by Kaluza-Klein modes of gauge bosons in a previously suggested model where three generations of the Standard Model fermions originate from a single generation in six dimensions. We find the bound on the size R of the extra spatial dimensions 1/R>3.3 TeV, which arises from the three-body decay B_s to K mu e. Due to the still too low statistics this bound is much less stringent than the constraint arising from K to mu e, 1/R>64 TeV, which was found in a previous work (Frere et al., JHEP, 2003). Nevertheless, we argue that a clear signature of the model would be an observation of K to mu e and B_s to K mu e decays without observations of other flavour and lepton number changing processes at the same precision level.Comment: 15 page

Towards Z_2-protected gauge--Higgs unification

In theories with flux compactification in eight or higher dimensions, the extra-dimensional components of the gauge field may be regarded as the Higgs field candidates. We suggest a way to protect these components from getting large tree-level masses by imposing a $Z_2$-symmetry acting on compact manifolds and background fields on them. In our scheme the infinite series of heavy KK modes naturally decouples from the light Higgs candidates, whose number is generically larger than one. We also present toy models with three families of leptons, illustrating that the Yukawa sector in our scheme is fairly strongly constrained. In one of these models, one fermion gets a tree-level mass after electroweak symmetry breaking, while two others remain naturally massless at the tree level.Comment: A few points clarified. Journal versio

Zero Modes of Matter Fields on Scalar Flat Thick Branes

Zero modes of various matters with spin 0, 1 and 1/2 on a class of scalar flat thick branes are discussed in this paper. We show that scalar field with spin 0 is localized on all thick branes without additional condition, while spin 1 vector field is not localized. In addition, for spin 1/2 fermionic field, the zero mode is localized on the branes under certain conditions.Comment: 11 pages,no figure

Mucosal immune responses following intestinal nematode infection.

In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years). Although these organisms have been eradicated to a large extent within westernized human populations, those living within rural areas of developing countries continue to suffer from high infection rates. Indeed, recent estimates indicate that approximately 2.5 billion people worldwide, mainly children, currently suffer from infection with intestinal helminths (also known as geohelminths and soil-transmitted helminths) . Paradoxically, the eradication of helminths is thought to contribute to the increased incidence of autoimmune diseases and allergy observed in developed countries. In this review, we will summarize our current understanding of host-helminth interactions at the mucosal surface that result in parasite expulsion or permit the establishment of chronic infections with luminal dwelling adult worms. We will also provide insight into the adaptive immune mechanisms that provide immune protection against re-infection with helminth larvae, a process that is likely to be key to the future development of successful vaccination strategies. Lastly, the contribution of helminths to immune modulation and particularly to the treatment of allergy and inflammatory bowel disease will be discussed

Angular Momentum Conservation Law for Randall-Sundrum Models

In Randall-Sundrum models, by the use of general Noether theorem, the covariant angular momentum conservation law is obtained with the respect to the local Lorentz transformations. The angular momentum current has also superpotential and is therefore identically conserved. The space-like components $J_{ij}$ of the angular momentum for Randall-Sundrum models are zero. But the component $J_{04}$ is infinite.Comment: 10 pages, no figures, accepted by Mod. Phys. Lett.

Energy-momentum for Randall-Sundrum models

We investigate the conservation law of energy-momentum for Randall-Sundrum models by the general displacement transform. The energy-momentum current has a superpotential and are therefore identically conserved. It is shown that for Randall-Sundrum solution, the momentum vanishes and most of the bulk energy is localized near the Planck brane. The energy density is $\epsilon = \epsilon_0 e^{-3k \mid y \mid}$.Comment: 13 pages, no figures, v4: introduction and new conclusion added, v5: 11 pages, title changed and references added, accepted by Mod. Phys. Lett.

West Nile Virus Vaccination Protects against Usutu Virus Disease in Mice

West Nile virus (WNV) and Usutu virus (USUV) are mosquito-borne flaviviruses that can cause neuroinvasive disease in humans. WNV and USUV circulate in both Africa and Europe and are closely related. Due to antigenic similarity, WNV-specific antibodies and USUV-specific antibodies have the potential to bind heterologous viruses; however, it is unclear whether this interaction may offer protection against infection. To investigate how prior WNV exposure would influence USUV infection, we used an attenuated WNV vaccine that contains the surface proteins of WNV in the backbone of a dengue virus 2 vaccine strain and protects against WNV disease. We hypothesized that vaccination with this attenuated WNV vaccine would protect against USUV infection. Neutralizing responses against WNV and USUV were measured in vitro using sera following vaccination. Sera from vaccinated CD-1 and Ifnar1-/- mice cross-neutralized with WNV and USUV. All mice were then subsequently challenged with an African or European USUV strain. In CD-1 mice, there was no difference in USUV titers between vaccinated and mock-vaccinated mice. However, in the Ifnar1-/- model, vaccinated mice had significantly higher survival rates and significantly lower USUV viremia compared to mock-vaccinated mice. Our results indicate that exposure to an attenuated form of WNV protects against severe USUV disease in mice and elicits a neutralizing response to both WNV and USUV. Future studies will investigate the immune mechanisms responsible for the protection against USUV infection induced by WNV vaccination, providing critical insight that will be essential for USUV and WNV vaccine development.Funding for this project was provided by NIH NIAID R21 AI53988. Support was also provided by the Virginia–Maryland College of Veterinary Medicine IRC.S

Are the New Physics Contributions from the Left-Right Symmetric Model Important for the Indirect CP Violation in the Neutral B Mesons?

Several works analyzing the new physics contributions from the Left-Right Symmetric Model to the CP violation phenomena in the neutral B mesons can be found in the literature. These works exhibit interesting and experimentally sensible deviations from the Standard Model predictions but at the expense of considering a low right scale \upsilon_R around 1 TeV. However, when we stick to the more conservative estimates for \upsilon_R which say that it must be at least 10^7 GeV, no experimentally sensible deviations from the Standard Model appear for indirect CP violation. This estimate for \upsilon_R arises when the generation of neutrino masses is considered. In spite of the fact that this scenario is much less interesting and says nothing new about both the CP violation phenomenon and the structure of the Left-Right Symmetric Model, this possibility must be taken into account for the sake of completeness and when considering the see-saw mechanism that provides masses to the neutrino sector.Comment: LaTex file. 19 pages, 4 figures. Change in the way the paper address the problem. As a result, change in title, abstract, and some sections. Conclusions unchanged. Version to appear in Foundations of Physics Letter

Fermion masses and quantum numbers from extra dimensions

We study the localization of fermions on a brane embedded in a space-time with $AdS_n \times M^k$ geometry. Quantum numbers of localized fermions are associated with their rotation momenta around the brane. Fermions with different quantum numbers have different higher-dimensional profiles. Fermion masses and mixings, which are proportional to the overlap of higher-dimensional profiles of the fermions, depend on the fermion quantum numbers.Comment: 14 page

Thermal production of axino Dark Matter

We reconsider thermal production of axinos in the early universe, adding: a) missed terms in the axino interaction; b) production via gluon decays kinematically allowed by thermal masses; c) a precise modeling of reheating. We find an axino abunance a few times larger than previous computations.Comment: 6 pages, 2 figures. Final version, to appear on JHE