The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility

Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA.Толл-подобные рецепторы (TLRs) играют важную роль в индукции и регуляции врожденной иммунной системы или адаптивных иммунных ответах. Показано, что что генетическая изменчивость TLRs человека связана с ревматоидным артритом (РА). Целью настоящей работы было изучение корреляций между однонуклеотидным полиморфизмом в сигнальной трансдукции TLRs и генами предрасположенности к РА. G-тип IL-1RAP rs766442 могут быть генами, предохраняющими от РА, в то время как аллели T-типа IL-6R rs11265618 и IL-1RAP rs766442 могут быть генами чувствительности к РА. Изучение полиморфизма нуклеиновых кислот в сигнальном пути TLRs может внести вклад в выявление участия генов в механизмах приступов РА, раннюю диагностику и лечение РА.The study was supported by Shandong Province young scientist in incentive fund (Grant № 2006BS03018) and National Natural Science Foundation of China (Grant № 30801025)

Adaptive Finite Element Methods with Inexact Solvers for the Nonlinear Poisson-Boltzmann Equation

In this article we study adaptive finite element methods (AFEM) with inexact solvers for a class of semilinear elliptic interface problems. We are particularly interested in nonlinear problems with discontinuous diffusion coefficients, such as the nonlinear Poisson-Boltzmann equation and its regularizations. The algorithm we study consists of the standard SOLVE-ESTIMATE-MARK-REFINE procedure common to many adaptive finite element algorithms, but where the SOLVE step involves only a full solve on the coarsest level, and the remaining levels involve only single Newton updates to the previous approximate solution. We summarize a recently developed AFEM convergence theory for inexact solvers, and present a sequence of numerical experiments that give evidence that the theory does in fact predict the contraction properties of AFEM with inexact solvers. The various routines used are all designed to maintain a linear-time computational complexity.Comment: Submitted to DD20 Proceeding

Identifying a Universal Activity Descriptor and a Unifying Mechanism Concept on Perovskite Oxides for Green Hydrogen Production

Producing indispensable hydrogen and oxygen for social development via water electrolysis shows more prospects than other technologies. Although electrocatalysts have been explored for centuries, a universal activity descriptor for both hydrogen-evolution reaction (HER) and oxygen-evolution reaction (OER) is not yet developed. Moreover, a unifying concept is not yet established to simultaneously understand HER/OER mechanisms. Here, the relationships between HER/OER activities in three common electrolytes and over ten representative material properties on 12 3d-metal-based model oxides are rationally bridged through statistical methodologies. The orbital charge-transfer energy (Δ) can serve as an ideal universal descriptor, where a neither too large nor too small Δ (≈1 eV) with optimal electron-cloud density around Fermi level affords the best activities, fulfilling Sabatier's principle. Systematic experiments and computations unravel that pristine oxide with Δ ≈ 1 eV possesses metal-like high-valence configurations and active lattice-oxygen sites to help adsorb key protons in HER and induce lattice-oxygen participation in the OER, respectively. After reactions, partially generated metals in the HER and high-valence hydroxides in the OER dominate proton adsorption and couple with pristine lattice-oxygen activation, respectively. These can be successfully rationalized by the unifying orbital charge-transfer theory. This work provides the foundation of rational material design and mechanism understanding for many potential applications

Implicações das prioridades de gasto do estado sobre a dinâmica econômica brasileira

XX Encontro Nacional de Economia Política: desenvolvimento Latino-Americano, Integração e Inserção Internacional - UNILA, Foz do Iguaçu, 26 a 29 de maio de 2015A sociedade brasileira tem passado, nas últimas décadas, por transformações importantes em seu contexto político e econômico. Este artigo trata principalmente de dois fatos que ainda, atualmente, impactam na dinâmica do gasto público. O processo de redemocratização, em fi nais dos anos de 1980 e a globalização econômica com a consequente fi nanceirização dos mercados. Estas transformações infl uenciam a forma de atuação do Estado na economia, principalmente no que se refere à defi nição de alocação de recursos públicos. Assim, este artigo aprofunda o entendimento da evolução das despesas públicas na esfera federal, pela análise dos gastos sociais bem como da dívida pública, constatando os impactos econômicos destas despesas e levantando conclusões sobre a viabilidade de determinados gastos governamentais sob a dinâmica econômica e social do país. A realização deste estudo contribui para o debate sobre as estratégias de política fi scal que vêm sendo adotadas e o impacto de priorização de determinados gastos, sobre o crescimento econômico do paísBanco Nacional de Desenvolvimento Econômico e Social (BNDES); Usina Hidrelétrica de Itaipu (ITAIPU); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Universidade Federal da Integração Latino-Americana (UNILA

Why doorstepping can increase household waste recycling

AbstractIn this study we report on a doorstepping intervention which produced a 12.5%, statistically significant, increase in the recycling capture rate. More importantly, we investigate why doorstepping caused the increase, through focus groups, structured interviews and questionnaires. By analyzing the findings with respect to a pragmatic set of eleven clusters of determinants of behaviour change, we find that social norms and emotion were important, with prompts as a more minor determinant. We can now plan further doorstepping knowing an emphasis on these is useful. Knowledge, skills, belief of consequences, belief of capability, action planning, role clarification, feedback, and motivation were determinant clusters found not to be important in this case.Recycling behaviour change interventions often do not generally produce transferable learning because they are usually presented as case studies and not broken down into key elements. Our analytical approach of breaking down a poorly defined activity – doorstepping – into elements which influence different clusters of determinants, and then exploring their separate impacts, allows some predictive planning and optimization for other interventions. The specific context here was residential food waste recycling in apartment blocks of communities in Shanghai, China

An Interactive Approach Based on Alternative Achievement Scale and Alternative Comprehensive Scale for Multiple Attribute Decision Making under Linguistic Environment

The aim of this paper is to develop an interactive approach for multiple attribute decision making with incomplete weight information under linguistic environment. Some of the concepts are defined, such as the distance between two 2-tuple linguistic variables, the expectation level of alternative, the achievement scale, the alternative comprehensive scale under linguistic environment. Based on these concepts, we establish some linear programming models, through which the decision maker interacts with the analyst. Furthermore, we establish a practical interactive approach for selecting the most desirable alternative(s). The interactive process can be realized by giving and revising the achievement scale and comprehensive scale of alternatives till the achievement scale and the comprehensive scale are achieved to the decision maker’s request. Finally, an illustrative example is also given.The author is very grateful to the associated editor and two anonymous referees for their insightful and constructive comments and suggestions that have led to an improved version of this paper. This work was partly supported by the National Natural Science Foundation of China (No. 90924027, No. 71101043), National Basic Research Program of China (973 Program, No. 2010C B951104), Key Program of National Social Science Foundation of China (No. 10AJY005), College Philosophy and Social Science Research Project of Jiangsu Province under Grant 2011SJD630007.Xu, Y.; Wang, H.; Palacios Marqués, D. (2013). An Interactive Approach Based on Alternative Achievement Scale and Alternative Comprehensive Scale for Multiple Attribute Decision Making under Linguistic Environment. International Journal of Computational Intelligence Systems. 6(1):87-95. https://doi.org/10.1080/18756891.2013.756226S87956

A switchable pH-differential unitized regenerative fuel cell with high performance

Regenerative fuel cells are a potential candidate for future energy storage, but their applications are limited by the high cost and poor round-trip efficiency. Here we present a switchable pH-differential unitized regenerative fuel cell capable of addressing both the obstacles. Relying on a membraneless laminar flow-based design, pH environments in the cell are optimized independently for different electrode reactions and are switchable together with the cell process to ensure always favorable thermodynamics for each electrode reaction. Benefiting from the thermodynamic advantages of the switchable pH-differential arrangement, the cell allows water electrolysis at a voltage of 0.57 V, and a fuel cell open circuit voltage of 1.89 V, rendering round-trip efficiencies up to 74%. Under room conditions, operating the cell in fuel cell mode yields a power density of 1.3 W cm¯², which is the highest performance to date for laminar flow-based cells and is comparable to state-of-the-art polymer electrolyte membrane fuel cells

Information strategy failure:personal interaction success, in urban residential food waste segregation

AbstractDirect measurements were taken of residential food waste sorting in a sample from over 5000 communities (5 million households) assigned to a pilot program delivered by government branches in Shanghai which relied on an information strategy for implementation. The results are compared to a population of N = 36 similar communities (36,000 households) assigned to a different program which involved considerable personal interaction. The results show that the information–based program communities did not noticeably sort their waste, whereas those given personal interaction approaches were very successful, with purity rates of 95%(8) and extra costs of about 50 RMB (8 USD) per household. This is a rare direct comparison of two different programs at such large scales, 6–36 months after launch, and suggests that personal interaction approaches should be considered by policy makers. Qualitative key informant interviews yielded data on each program's activities, which provide suggestions for further studies of the underlying behaviour change determinants involved

Measurements of the observed cross sections for exclusive light hadron production in e^+e^- annihilation at \sqrt{s}= 3.773 and 3.650 GeV

By analyzing the data sets of 17.3 pb$^{-1}$ taken at $\sqrt{s}=3.773$ GeV and 6.5 pb$^{-1}$ taken at $\sqrt{s}=3.650$ GeV with the BESII detector at the BEPC collider, we have measured the observed cross sections for 12 exclusive light hadron final states produced in $e^+e^-$ annihilation at the two energy points. We have also set the upper limits on the observed cross sections and the branching fractions for $\psi(3770)$ decay to these final states at 90% C.L.Comment: 8 pages, 5 figur