Molecular docking studies on rocaglamide, a traditional Chinese medicine for periodontitis

Purpose: To undertake an in silico assessment of rocaglamide as a potential drug therapy forperiodontitis (dental arthritis).Method: Lamarckian algorithm-based automated docking approach using AutoDock4.2 tool wasapplied for calculating the best possible binding mode of rocaglamide to IL-23p19 and IL-17, the targets of anti-inflammatory drugs in periodontal disease.Results: The top two interactions of rocaglamide with IL-17 (ΔG = -5.45 and -4.83 kcal/mol) were more spontaneous, and the physical interactions (two hydrogen bonds and one π-πbond) generated in the two IL-17- rocaglamide complexes were higher in number than in IL-23p14-rocaglamide complexes.Conclusion: In silico analysis of rocaglamide, a known antimicrobial and anti-inflammatory agent, is a promising natural candidate for periodontitis therapy, and should be further subjected to in vitro and in vivo anti-periodontitis investigations.Keywords: Periodontitis, Inflammation, Rocaglamide, Molecular docking, Lamarckian algorithm, IL- 23p19, IL-1

Study on Smoke Control of Wuhan CBD Urban Traffic Link Tunnel

AbstractAn Urban Traffic Link Tunnel (UTLT) is a novel type of underground transportation system consisting of a main tunnel in a loop shape and several linked tunnels. It has a higher level of fire risk compared to other common road tunnels. In this study, numerical and experimental study has been conducted to investigate the smoke control of Wuhan Central Business District (CBD) UTLT. The transient distributions of the smoke spread have been analyzed, and the optimal smoke control strategy for the Wuhan CBD UTLT has been put forward

Adaptive Dynamic Surface Control for Generator Excitation Control System

For the generator excitation control system which is equipped with static var compensator (SVC) and unknown parameters, a novel adaptive dynamic surface control scheme is proposed based on neural network and tracking error transformed function with the following features: (1) the transformation of the excitation generator model to the linear systems is omitted; (2) the prespecified performance of the tracking error can be guaranteed by combining with the tracking error transformed function; (3) the computational burden is greatly reduced by estimating the norm of the weighted vector of neural network instead of the weighted vector itself; therefore, it is more suitable for the real time control; and (4) the explosion of complicity problem inherent in the backstepping control can be eliminated. It is proved that the new scheme can make the system semiglobally uniformly ultimately bounded. Simulation results show the effectiveness of this control scheme

Compact Antenna with Enhanced Performances Using Artificial Meta-Surfaces

In recent years, artificial meta‐surfaces, with the advantages of smaller physical space and less losses compared with three‐dimensional (3D) metamaterials (MTM), have intrigued a great impetus and been applied widely to cloaks, subwavelength planar lenses, holograms, etc. Typically, one most important part for meta‐surfaces’ applications is to improve the performance of antennas. In this chapter, we discuss our effort in exploring novel mechanisms of enhancing the antenna bandwidth using the magneto‐electro‐dielectric waveguided meta‐surface (MED‐WG‐MS), achieving circular polarization radiation through fractal meta‐surface, and also realizing beam manipulation using cascaded resonator layers, which is demonstrated from aspects of theoretical analysis, numerical calculation, and experimental measurement. The numerical and measured results coincide well with each other. Note that all designed antenna and microwave devices based on compact meta‐surfaces show advantages compared with the conventional cases

Semi-quantum private comparison and its generalization to the key agreement, summation, and anonymous ranking

Semi-quantum protocols construct connections between quantum users and ``classical'' users who can only perform certain ``classical'' operations. In this paper, we present a new semi-quantum private comparison protocol based on entangled states and single particles, which does not require pre-shared keys between the ``classical'' users to guarantee the security of their private data. By utilizing multi-particle entangled states and single particles, our protocol can be easily extended to multi-party scenarios to meet the requirements of multiple ``classical'' users who want to compare their private data. The security analysis shows that the protocol can effectively prevent attacks from outside eavesdroppers and adversarial participants. Besides, we generalize the proposed protocol to other semi-quantum protocols such as semi-quantum key agreement, semi-quantum summation, and semi-quantum anonymous ranking protocols. We compare and discuss the proposed protocols with previous similar protocols. The results show that our protocols satisfy the demands of their respective counterparts separately. Therefore, our protocols have a wide range of application scenarios.Comment: 19 pages 5 table

Theoretical calculation of the ‘natural flock restoration’ time of a cotton comber

Based on the overhanging beam theory, the stress on the flock of a cotton comber has been analyzed, and the natural frequency of the ‘natural flock restoration’ is calculated in combination with energy method. Finally, a theoretical model of the ‘natural flock restoration’ time has been developed. The model illustrates that the ‘natural flock restoration’ time of a cotton comber is determined by cotton properties, combing process and mechanical structure. The established theoretical model corrects the previous calculation method for the ‘natural flock restoration’ time of a cotton comber. The finding provides information for the development of a new type of cotton comber with high velocity