Distribution of Copper in Rats Submitted to Treatment With Copper Aspirinate

The distribution of copper in Sprague – Dawley rats following a three month oral administration of 0,10 or 50mg/kg copper aspirinate has been investigated. Metal content was determined by ICP – AES in blood, brain, kidney, liver, lung, spleen, and dejection. The results show that treatment with copper aspirinate did not cause accumulation of copper in rats and excess ingested copper was excreted through feces

Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases

The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On cereral ischemia model pretreatment with 0.018mmol/kg copper aspirinate ig significantly increased survival of animals and the density of intact hippocampal CA1 cells and decreased brain calcium concentration. Its anticerebral ischemia activity was superior to or equal to nimodipine. It is, therefore, suggested that copper aspirinate is very promising in becoming an antithrombotic drug in preventing and treating thrombotic diseases

Ionic liquid-based synergistic extraction of rare earths nitrates without diluent: Typical ion-association mechanism

The coexistence of tricaprylmethylammonium nitrate ([A336][NO3]) and Di(2-ethylhexyl) 2-ethylhexyl phosphonate (DEHEHP) has been found an obvious synergistic extraction effect for rare earths nitrates. In this work, synergistic extraction behaviors without any diluent for rare earth nitrates based on tri(hexyl)tetradecylphosphonium chloride (Cyphos (R) IL 101, [P66614][Cl]) and DEHEHP have been further investigated. Pr(III) was still used as a model RE, and the maximum synergistic extraction distribution ratio was obtained at a volume ratio of 2:3 for [P66614][Cl] and DEHEHP. The synergistic enhancement coefficients have been tested for the whole rare earths. Results show that there is an obvious synergistic enhancement effect for light REs (La-Sm) and an anti-synergistic effect for Gd-Lu including Y. The effects of acidity, anions and metal ion concentrations on the extraction have been investigated. The extraction mechanism has been confirmed to be the typical ion-association reactions. The maximum loading capacity is 0.78 mol/L Pr at 293.15 K. The extraction ability of [P66614][Cl]-DEHEHP is superior to that of reported [A336][NO3]-DEHEHP, and is also greater than that of common acidic organophosphate-kerosene extraction system. Stripping, recyclability, and selectivity between REs and non-REs, has also been investigated. (C) 2017 Elsevier B.V. All rights reserved.</p

Sep. Sci. Technol.

Adsorption properties of different adsorbents such as reduced NiY, AgY, alumina, 13X, and activated carbon were studied with dibenzothiophene (DBT) and naphthalene as model compounds. The desorption of DBT was carried on thermo gravimetric-differential thermal analysis (TG-DTA). The interaction of DBT with different adsorbents follows the sequence: activated carbon &gt; reduced NiY &gt; AgY &gt; activated alumina &gt; 13X. The bio-regeneration of these adsorbents was studied with P. delafieldii R-8 as desulfurization strains. Adding P. delafieldii R-8 cells can improve DBT desorption from adsorbent AgY. The desorption of DBT from adsorbents by bioregeneration of adsorbents follows the sequence: 13X &gt; alumina &gt; AgY &gt; reduced NiY &gt; activated carbon. The presence of naphthalene can decrease the desorption of sulfur compounds. The adsorption capacity of AgY decreases for the first time recycling and then changes little. The decrease of the adsorption capacity is due to the loss of Ag+ ions.Adsorption properties of different adsorbents such as reduced NiY, AgY, alumina, 13X, and activated carbon were studied with dibenzothiophene (DBT) and naphthalene as model compounds. The desorption of DBT was carried on thermo gravimetric-differential thermal analysis (TG-DTA). The interaction of DBT with different adsorbents follows the sequence: activated carbon > reduced NiY > AgY > activated alumina > 13X. The bio-regeneration of these adsorbents was studied with P. delafieldii R-8 as desulfurization strains. Adding P. delafieldii R-8 cells can improve DBT desorption from adsorbent AgY. The desorption of DBT from adsorbents by bioregeneration of adsorbents follows the sequence: 13X > alumina > AgY > reduced NiY > activated carbon. The presence of naphthalene can decrease the desorption of sulfur compounds. The adsorption capacity of AgY decreases for the first time recycling and then changes little. The decrease of the adsorption capacity is due to the loss of Ag+ ions

Catal. Commun.

Superparamagnetic Fe3O4 nanoparticles are prepared with coprecipitation method followed by modification with ammonia oleate. Magnetic P. delafieldii R-8 cells can be prepared by mixing the cells with magnetite nanoparticles. Saturated magnetization of magnetic cells is about 7.41 emu/g. The pH value of magnetic suspension has significant influence on the desulfurization activity of magnetic cells. Desulfurization of the magnetic cells prepared with pH 7.0 magnetic suspension has similar activity with free cells. When the magnetic cells were used in the bioregeneration of desulfurization adsorbents Ag-Y, the concentration of dibenzothiophene (DBT) and 2-hydroxybiphenyl (2-HBP) with free cells is a little higher that that with magnetic cells. Adsorption capacity of the regenerated adsorbent is 93% that of the fresh one after being desorbed with magnetic P. delafieldii R-8, dried at 100 degrees C for 24 h and calcined in the air at 500 degrees C for 4 h. (c) 2007 Elsevier B.V. All rights reserved.Superparamagnetic Fe3O4 nanoparticles are prepared with coprecipitation method followed by modification with ammonia oleate. Magnetic P. delafieldii R-8 cells can be prepared by mixing the cells with magnetite nanoparticles. Saturated magnetization of magnetic cells is about 7.41 emu/g. The pH value of magnetic suspension has significant influence on the desulfurization activity of magnetic cells. Desulfurization of the magnetic cells prepared with pH 7.0 magnetic suspension has similar activity with free cells. When the magnetic cells were used in the bioregeneration of desulfurization adsorbents Ag-Y, the concentration of dibenzothiophene (DBT) and 2-hydroxybiphenyl (2-HBP) with free cells is a little higher that that with magnetic cells. Adsorption capacity of the regenerated adsorbent is 93% that of the fresh one after being desorbed with magnetic P. delafieldii R-8, dried at 100 degrees C for 24 h and calcined in the air at 500 degrees C for 4 h. (c) 2007 Elsevier B.V. All rights reserved

Korean J. Chem. Eng.

High production of Rhodococcus erythropolis LSSE8-1 and its application for the treatment of diesel oils was investigated. Culture conditions were optimized by Taguchi orthogonal array experimental design methodology. High cell density cultivation of biocatalyst with pH control and fed-batch feeding strategies was further validated in a fermentor with the optimal factors. Cell concentration of 23.9 g dry cells/L was obtained after 96 h cultivation. The resting cells and direct fermentation suspension were applied for deep desulfurization of hydrodesulfurized diesel oils. It was observed that the sulfur content of the diesel decreased from 248 to 51 mu g/g by two consecutive biodesulfurizations. It implied that the biodesulfurization process can be simplified by directly mixing cell cultivation suspension with diesel oil. The biocatalyst developed with the Taguchi method has the potential to be applied to produce ultra-low-sulfur petroleum oils.High production of Rhodococcus erythropolis LSSE8-1 and its application for the treatment of diesel oils was investigated. Culture conditions were optimized by Taguchi orthogonal array experimental design methodology. High cell density cultivation of biocatalyst with pH control and fed-batch feeding strategies was further validated in a fermentor with the optimal factors. Cell concentration of 23.9 g dry cells/L was obtained after 96 h cultivation. The resting cells and direct fermentation suspension were applied for deep desulfurization of hydrodesulfurized diesel oils. It was observed that the sulfur content of the diesel decreased from 248 to 51 mu g/g by two consecutive biodesulfurizations. It implied that the biodesulfurization process can be simplified by directly mixing cell cultivation suspension with diesel oil. The biocatalyst developed with the Taguchi method has the potential to be applied to produce ultra-low-sulfur petroleum oils