Synthesis of benzo-, pyrido-, thieno- and imidazo-fused N-hydroxy-4-oxopyrimidine-2-carboxylic acid derivatives

N-Hydroxy-4-oxoquinazoline-2-carboxamide derivatives (cyclic hydroxamic acids) and related pyrido- and thieno-substituted analogues, as well as a N-hydroxyhypoxanthine-2-carboxamide were synthesised for the first time, by means of a four-step sequence that involves a smooth reaction of aminohydroxamates with methyl trimethoxyacetate. Other strategies were unsuccessful

Particle Swarm Optimization, Genetic Algorithm and Grey Wolf Optimizer Algorithms Performance Comparative for a DC-DC Boost Converter PID Controller

[EN] Power converters are electronic devices widely applied in industry, and in recent years, for renewable energy electronic systems, they can regulate voltage levels and actuate as interfaces, however, to do so, is needed a controller. Proportional-Integral-Derivative (PID) are applied to power converters comparing output voltage versus a reference voltage to reduce and anticipate error. Using PID controllers may be complicated since must be previously tuned prior to their use. Many methods for PID controllers tunning have been proposed, from classical to metaheuristic approaches. Between the metaheuristic approaches, bio-inspired algorithms are a feasible solution; Particle Swarm Optimization (PSO) and Genetic Algorithms (GA) are often used; however, they need many initial parameters to be specified, this can lead to local solutions, and not necessarily the global optimum. In recent years, new generation metaheuristic algorithms with fewer initial parameters had been proposed. The Grey Wolf Optimizer (GWO) algorithm is based on wolves¿ herds chasing habits. In this work, a comparison between PID controllers tunning using GWO, PSO, and GA algorithms for a Boost Converter is made. The converter is modeled by state-space equations, and then the optimization of the related PID controller is made using MATLAB/Simulink software. The algorithm¿s performance is evaluated using the Root Mean Squared Error (RMSE). Results show that the proposed GWO algorithm is a feasible solution for the PID controller tunning problem for power converters since its overall performance is better than the obtained by the PSO and GA.The authors wish to thank the Institute of Energy Engineering of the Polytechnic University of Valencia, Spain, and the Department of Water and Energy Studies of the University of Guadalajara, Mexico, for all their support and collaboration.Águila-León, J.; Chiñas-Palacios, C.; Vargas-Salgado Carlos; Hurtado-Perez, E.; García, EXM. (2021). Particle Swarm Optimization, Genetic Algorithm and Grey Wolf Optimizer Algorithms Performance Comparative for a DC-DC Boost Converter PID Controller. Advances in Science, Technology and Engineering Systems Journal. 6(1):619-625. https://doi.org/10.25046/aj060167S61962561J. Aguila-Leon, C.D. Chinas-Palacios, C. Vargas-Salgado, E. Hurtado-Perez, E.X.M. Garcia, "Optimal PID Parameters Tunning for a DC-DC Boost Converter: A Performance Comparative Using Grey Wolf Optimizer, Particle Swarm Optimization and Genetic Algorithms," in 2020 IEEE Conference on Technologies for Sustainability, SusTech 2020, 2020, doi:10.1109/SusTech47890.2020.9150507.H. Sira-Ramírez, R. Silva-Ortigoza, Control Design Techniques in Power Electronic Devices, 2013, doi:10.1017/CBO9781107415324.004.G.A. Raiker, S.R. B, P.C. Ramamurthy, L. Umanand, S.G. Abines, S.G. Vasisht, "Solar PV interface to Grid-Tie Inverter with Current Referenced Boost Converter," in 2018 IEEE 13th International Conference on Industrial and Information Systems (ICIIS), IEEE: 343-348, 2018, doi:10.1109/ICIINFS.2018.8721313.S.E. Babaa, G. El Murr, F. Mohamed, S. Pamuri, "Overview of Boost Converters for Photovoltaic Systems," Journal of Power and Energy Engineering, 06(04), 16-31, 2018, doi:10.4236/jpee.2018.64002.J. Berner, K. Soltesz, T. Hägglund, K.J. Åström, "An experimental comparison of PID autotuners," Control Engineering Practice, 73, 124-133, 2018, doi:10.1016/J.CONENGPRAC.2018.01.006.K. Ogata, Modern Control Engineering, 5th ed., Prentice Hall, 2010.K. Nisi, B. Nagaraj, A. Agalya, "Tuning of a PID controller using evolutionary multi objective optimization methodologies and application to the pulp and paper industry," International Journal of Machine Learning and Cybernetics, 10(8), 2015-2025, 2019, doi:10.1007/s13042-018-0831-8.M.T. Özdemir, D. Öztürk, "Comparative performance analysis of optimal PID parameters tuning based on the optics inspired optimization methods for automatic generation control," Energies, 10(12), 2017, doi:10.3390/en10122134.G.-Q. Zeng, X.-Q. Xie, M.-R. Chen, "An Adaptive Model Predictive Load Frequency Control Method for Multi-Area Interconnected Power Systems with Photovoltaic Generations," Energies, 10(11), 1840, 2017, doi:10.3390/en10111840.Y. Sawle, S.C. Gupta, A.K. Bohre, "Optimal sizing of standalone PV/Wind/Biomass hybrid energy system using GA and PSO optimization technique," Energy Procedia, 117, 690-698, 2017, doi:10.1016/j.egypro.2017.05.183.S. Surender Reddy, C. Srinivasa Rathnam, "Optimal Power Flow using Glowworm Swarm Optimization," International Journal of Electrical Power & Energy Systems, 80, 128-139, 2016, doi:10.1016/J.IJEPES.2016.01.036.C.Y. Acevedo-arenas, A. Correcher, C. Sánchez-díaz, E. Ariza, D. Alfonso-solar, C. Vargas-salgado, J.F. Petit-suárez, "MPC for optimal dispatch of an AC-linked hybrid PV / wind / biomass / H2 system incorporating demand response," Energy Conversion and Management, 186(February), 241-257, 2019, doi:10.1016/j.enconman.2019.02.044.M. Çelebi, "Efficiency optimization of a conventional boost DC/DC converter," Electrical Engineering, 100(2), 803-809, 2018, doi:10.1007/s00202-017-0552-0.Q.Y. Lu, W. Hu, L. Zheng, Y. Min, M. Li, X.P. Li, W.C. Ge, Z.M. Wang, "Integrated coordinated optimization control of automatic generation control and automatic voltage control in regional power grids," Energies, 5(10), 3817-3834, 2012, doi:10.3390/en5103817.J. Aguila‐Leon, C. Chiñas‐Palacios, E.X.M. Garcia, C. Vargas‐Salgado, "A multimicrogrid energy management model implementing an evolutionary game‐theoretic approach," International Transactions on Electrical Energy Systems, 30(11), 2020, doi:10.1002/2050-7038.12617.Ovat Friday Aje, Anyandi Adie Josephat, "The particle swarm optimization (PSO) algorithm application - A review," Global Journal of Engineering and Technology Advances, 3(3), 001-006, 2020, doi:10.30574/gjeta.2020.3.3.0033.N.K. Jain, U. Nangia, J. Jain, A Review of Particle Swarm Optimization, Journal of The Institution of Engineers (India): Series B, 99(4), 407-411, 2018, doi:10.1007/s40031-018-0323-y.B. Hekimoǧlu, S. Ekinci, S. Kaya, "Optimal PID Controller Design of DC-DC Buck Converter using Whale Optimization Algorithm," in 2018 International Conference on Artificial Intelligence and Data Processing, IDAP 2018, Institute of Electrical and Electronics Engineers Inc., 2019, doi:10.1109/IDAP.2018.8620833.S. Mirjalili, S.M. Mirjalili, A. Lewis, "Grey Wolf Optimizer," Advances in Engineering Software, 69, 46-61, 2014, doi:10.1016/j.advengsoft.2013.12.007.S.-X. Li, J.-S. Wang, "Dynamic Modeling of Steam Condenser and Design of PI Controller Based on Grey Wolf Optimizer," Mathematical Problems in Engineering, 2015, 1-9, 2015, doi:10.1155/2015/120975.S. Yadav, S.K. Verma, S.K. Nagar, "Optimized PID Controller for Magnetic Levitation System," IFAC-PapersOnLine, 49(1), 778-782, 2016, doi:10.1016/J.IFACOL.2016.03.151.R.H.G. Tan, L.Y.H. Hoo, "DC-DC converter modeling and simulation using state space approach," 2015 IEEE Conference on Energy Conversion (CENCON), (2), 42-47, 2015, doi:10.1109/CENCON.2015.7409511

Entropía de vertidos residuales en la economía local de los habitantes de la Laguna de Zapotlán, México.

One of the main economic sources for the commu-nities near the Laguna de Zapotlán has to do with the use of the resources coming from this wetland loca-ted in western Mexico. However, activities such as fishing, tourism and trade of handicrafts made from Schoenoplectus acutus have recently been affec-ted. In this way, the objective of this work identi-fies the relationship of the local economy and the management and treatment of residual discharges in the lagoon, through the content analysis and the realization of a quasi-ethnographic exercise. The re-sults suggest that the incorporation of contaminated flows from human settlements and agricultural acti-vities has led to a entropy in the system.Una de las principales fuentes económicas para las comunidades cercanas a la Laguna de Zapot-lán, tiene que ver con el aprovechamiento de los recursos provenientes de este humedal ubicado en el occidente de México. Sin embargo, actividades como la pesca, el turismo y el comercio de artesa-nías elaboradas de Schoenoplectus acutus se han visto afectadas recientemente. De tal forma, que el objetivo de este trabajo identifica la relación de la economía local y el manejo y tratamiento de los vertidos residuales en la laguna, a través del aná-lisis de contenido y la realización de un ejercicio cuasi-etnográfico. Los resultados sugieren que la incorporación de caudales contaminados prove-nientes de asentamientos humanos y actividades agropecuarias, han conducido a una entropía en el sistema ecológico, incrementando el eichhornia crassipes y mermando la economía de la región

Biofunctionalized Zinc Oxide Field Effect Transistors for Selective Sensing of Riboflavin with Current Modulation

Zinc oxide field effect transistors (ZnO-FET), covalently functionalized with single stranded DNA aptamers, provide a highly selective platform for label-free small molecule sensing. The nanostructured surface morphology of ZnO provides high sensitivity and room temperature deposition allows for a wide array of substrate types. Herein we demonstrate the selective detection of riboflavin down to the pM level in aqueous solution using the negative electrical current response of the ZnO-FET by covalently attaching a riboflavin binding aptamer to the surface. The response of the biofunctionalized ZnO-FET was tuned by attaching a redox tag (ferrocene) to the 3′ terminus of the aptamer, resulting in positive current modulation upon exposure to riboflavin down to pM levels

Electrode surface treatment and electrochemical impedance spectroscopy study on carbon/carbon supercapacitors

Power improvement in supercapacitors is mainly related to lowering the internal impedance. The real part of the impedance at a given frequency is called ESR (equivalent series resistance). Several contributions are included in the ESR: the electrolyte resistance (including the separator), the active material resistance (with both ionic and electronic parts) and the active material/current collector interface resistance. The first two contributions have been intensively described and studied by many authors. The first part of this paper is focused on the use of surface treatments as a way to decrease the active material/current collector impedance. Al current collector foils have been treated following a two-step procedure: electrochemical etching and sol-gel coating by a highly-covering, conducting carbonaceous material. It aims to increase the Al foil/active material surface contact leading to lower resistance. In a second part, carbon-carbon supercapacitor impedance is discussed in term of complex capacitance and complex power from electrochemical impedance spectroscopy data. This representation permits extraction of a relaxation time constant that provides important information on supercapacitor behaviour. The influence of carbon nanotubes addition on electrochemical performance of carbon/carbon supercapacitors has also been studied by electrochemical impedance spectroscopy

Multiethnic Meta-Analysis Identifies Ancestry-Specific and Cross-Ancestry Loci for Pulmonary Function

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci