Simultaneous extracellular recordings in S1BF and S2 by different doses of propofol.

<p>Spontaneous activity (A, C, E) and whisker-triggered responses (B, D, F) were shown in different panels. Extracellular recording were performed in S1BF (green) and S2 (red). Panel A and B: 20 mg/kg/h; Panel C and D: 40 mg/kg/h; Panel E and F: 80 mg/kg/h.</p

Dose-dependent group-average effects of propofol on VOCR and TPR.

<p>Compared with group A and group B,*p<0.05 and ▴p<0.05 mean level of significance, respectively.</p

The ERP amplitude and latency (peak and response latency) in S1BF and S2. Panel.

<p>A) The left, upper graph shows the change of amplitude by whisker stimulation. The amplitude of S1BF was larger than that in S2 in group A, B and C. B) The right, upper graph shows the change of peak latency by whisker stimulation. The peak latency of S1BF was longer than that in S2 in group A, B and C. C) The left, lower graph shows the time interval of peak latency between S1BF and S2 and there was no difference among the three groups. D) The right lower graph shows the response latency in S1BF and S2. The response latency of S1BF was shorter than that in S2 in three different rates. Compared with group A(20 mg/kg/h), the response latency in group C(80 mg/kg/h) was longer in both S1BF and S2. It gradually decreased to the basic level ▴ p<0.05, *p<0.05, level of significance.</p

The changes of EEG power: Delta (1–4 Hz), Theta (4–8 Hz), Alpha (8–12 Hz), Bata (12–25 Hz) and Gamma band(25–100 Hz) as well as Spindle wave(7–14 Hz) in S1BF and S2 when the rats were infused with propofol infused at 20, 40 and 80 mg/kg/h.

<p>A) EEG power in S1BF at different dosage of propofol and no difference among the three groups(infusion rates); B) EEG power in S2 at different dosages of propofol and no difference among the three groups except the delta power in propofol 80 mg/kg/h was stronger than that in propofol 20 mg/kg/h; C) The change of theta power under different dosages of propofol. The power of θ wave in S2 was larger than that in S1BF In any group A,B and C *p<0.05.</p

The cross-correlation between S1BF and S2 at different doses of propofol.

<p>A) The correlation coefficient between S1BF and S2. B) The averaged correlation coefficient was calculated with different infusion rate of propofol. The correlation coefficient was decreased gradually as raising the doses of propofol *p<0.05 and ▴p<0.05. SpS: spontaneous state, SS: stimulation state.</p

The spikes by whisker stimulation in S1BF and S2 by different doses of propofol.

<p>The response in S1BF (A) and in S2 (B). The change in spikes was expressed along different time period since the onset of drug application. The spikes triggered by whisker stimuli were significantly increased compared with pre-sti. It gradually decreased to the basic level (pre-sti) in 4 s. (pre-sti: 1 s before stimuli; sti: stimulation; post-1∶1 s after stimulation; post-2∶2 s after stimulation; post-3∶3 s after stimulation; post-4∶4 s after stimulation).</p

The up and down state in S1BF at different doses of propofol.

<p>A) The proportion of up state, down state and up/down state in S1BF and found no significant difference between the three groups. B) The relationship between the input resistance and different infusion rate. Compared with groups, the input resistance was larger than that in group A (20 mg/kg/h) and smaller than that in group C (80 mg/kg/h) *p<0.05 and ▴p<0.05.</p