Robust Andrew's sine estimate adaptive filtering

The Andrew's sine function is a robust estimator, which has been used in outlier rejection and robust statistics. However, the performance of such estimator does not receive attention in the field of adaptive filtering techniques. Two Andrew's sine estimator (ASE)-based robust adaptive filtering algorithms are proposed in this brief. Specifically, to achieve improved performance and reduced computational complexity, the iterative Wiener filter (IWF) is an attractive choice. A novel IWF based on ASE (IWF-ASE) is proposed for impulsive noises. To further reduce the computational complexity, the leading dichotomous coordinate descent (DCD) algorithm is combined with the ASE, developing DCD-ASE algorithm. Simulations on system identification demonstrate that the proposed algorithms can achieve smaller misalignment as compared to the conventional IWF, recursive maximum correntropy criterion (RMCC), and DCD-RMCC algorithms in impulsive noise. Furthermore, the proposed algorithms exhibit improved performance in partial discharge (PD) denoising.Comment: 5 pages, 5 figure

Surface Functionalization of Black Phosphorus via Amine Compounds and Its Impacts on the Flame Retardancy and Thermal Decomposition Behaviors of Epoxy Resin.

Recently, lots of effort has been placed into stabilizing black phosphorus (BP) in the air to improve its compatibility with polymers. Herein, BP was chemically functionalized by aliphatic amine (DETA), aromatic amine (PPDA) and cyclamine (Pid) via a nucleophilic substitution reaction, aiming to develop an intensively reactive BP flame retardant for epoxy resin (EP). The -NH2 group on BP-DETA, BP-PPDA and BP-Pid reacted with the epoxide group at different temperatures. The lowest temperature was about 150 °C for BP-DETA. The impacts of three BP-NH2 were compared on the flame retardancy and thermal decomposition of EP. At 5 wt% loading, EP/BP-NH2 all passed UL 94 V 0 rating. The limiting oxygen index (LOI) of EP/BP-PPDA was as high as 32.3%. The heat release rate (HRR) of EP/BP-DETA greatly decreased by 46% and char residue increased by 73.8%, whereas HRR of EP/BP-Pid decreased by 11.5% and char residue increased by 50.8%, compared with EP. Average effective heat of combustion (av-EHC) of EP/BP-Pid was lower than that of EP/BP-DETA and EP/BP-PPDA. In view of the flame-retardant mechanism, BP nanosheets functionalized with aliphatic amine and aromatic amine played a dominant role in the condensed phase, while BP functionalized with cyclamine was more effective in the gas phase.post-print74881 K

Nanoporous Structure of Sintered Metal Powder Heat Exchanger in Dilution Refrigeration: A Numerical Study

We use LAMMPS to randomly pack hard spheres to simulate the heat exchanger, where the hard spheres represent sintered metal particles in the heat exchanger. We simulated the heat exchanger under different sphere radii and different packing fractions of the metal particle and researched pore space. To improve the performance of the heat exchanger, we adopted this simulation method to explore when the packing fraction is 65%, the optimal sintering particle radius in the heat exchanger is 30~35nm.Comment: 5 pages,3 figures, one tabl

Natural polysaccharide-incorporated hydroxyapatite as size-changeable, nuclear-targeted nanocarrier for efficient cancer therapy

Targeted delivery of anticancer drugs is one of the most promising methods for cancer therapy. However, barriers including complicated procedures, costly preparation, and toxic side effects have restricted the development of nuclear-targeted nanocarriers. Natural polysaccharides as extracellular matrix constituents or analogs play an important role in biomineralization. Herein, a simple, polysaccharide-intervened preparation of hydroxyapatite (HA) hybrid nanoparticles (NPs) with low crystallinity was used as a bio-safe carrier for targeting the delivery of doxorubicin (DOX) for efficient anticancer therapy. The poorly crystallized hybrid HA NPs were specifically taken up by cancer cells (HeLa cells), and subsequently, the abrupt degradation of HA nanoparticles would cause a change in the osmotic pressure, leading to the explosive death of cancer cells. Furthermore, the hybrid HA NPs were size changeable and capable of directly delivering the anti-cancer drug into the nucleus of cancer cells, thereby efficiently killing cancer cells. In addition, the HA/ALG NPs reduce the toxicity of DOX to L929 cells and cause little negative effect on normal tissue cells. The in vitro and in vivo experiments confirmed that the size-changeable HA-ALG/DOX could be a promising nuclear-targeted delivery nanocarrier for efficient cancer therapy.</p

Charge-separation driven mechanism via acylium ion intermediate migration during catalytic carbonylation in mordenite zeolite

By employing ab initio molecular dynamic simulations, solid-state NMR spectroscopy, and two-dimensional correlation analysis of rapid scan Fourier transform infrared spectroscopy data, a new pathway is proposed for the formation of methyl acetate (MA) via the acylium ion (i.e.,CH(3) − C ≡ O(+)) in 12-membered ring (MR) channel of mordenite by an integrated reaction/diffusion kinetics model, and this route is kinetically and thermodynamically more favorable than the traditional viewpoint in 8MR channel. From perspective of the complete catalytic cycle, the separation of these two reaction zones, i.e., the C-C bond coupling in 8MR channel and MA formation in 12MR channel, effectively avoids aggregation of highly active acetyl species or ketene, thereby reducing undesired carbon deposit production. The synergistic effect of different channels appears to account for the high carbonylation activity in mordenite that has thus far not been fully explained, and this paradigm may rationalize the observed catalytic activity of other reactions

Soluble CD40 ligand-activated human peripheral B cells as surrogated antigen presenting cells: A preliminary approach for anti-HBV immunotherapy

<p>Abstract</p> <p>Background</p> <p>We aimed to clarify whether soluble CD40 ligand (sCD40L) activated B cells may be loaded with HBcAg18-27 peptide and served as antigen-producing cells (APCs) to induce HBV-specific cytolytic T lymphocytes (CTLs).</p> <p>Results</p> <p>Human B cells could be cultured in the presence of sCD40L up to 54 days, and the proportion of B cells in the S phase increased from 0% to 8.34% in the culture. The expression of CD80, CD86, major histocompatibility complex (MHC) classes I and II molecules on the sCD40L-activated B cell was significantly increased after long-time culture. Cytometry and fluorescence microscopy showed that more than 98% sCD40L-activated B cells were loaded by the HBcAg peptide. Furthermore, the peptide-pulsed activated B cells could induce HBcAg18-27 specific CTLs.</p> <p>Conclusions</p> <p>Our results demonstrate that sCD40L-activated B cells may function as APCs and induce HBV-specific CTLs.</p

Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients

CD4+ T cells serve as master regulators of the adaptive immune response to HBV. However, CD4+ T-cell subsets are heterogeneous, and it remains unknown how the antiviral agents affect the different CD4+ T cell subtypes. To this end, the expressions of signature transcription factors and cytokines of CD4+ T-cell subtypes were examined in hepatitis B patients before and after treatment with telbivudine. Results showed that, upon the rapid HBV copy decrease induced by telbivudine treatment, the frequencies and related cytokines of Th17 and Treg cells were dramatically decreased, while those for Th2 cells were dramatically increased. No obvious changes were observed in Th1 cell frequencies; although, IFN-γ expression was upregulated in response to telbivudine treatment, suggesting another cell source of IFN-γ in CHB patients. Statistical analyses indicated that Th17 and Tr1 (a Treg subtype) cells were the most sensitive subpopulations of the peripheral blood CD4+ T cells to telbivudine treatment over 52 weeks. Thus, Th17 and Tr1 cells may represent a suitable and effective predictor of responsiveness during telbivudine therapy. These findings not only improve our understanding of hepatitis pathogenesis but also can aid in future development of appropriate therapeutic strategies to control viral hepatitis

Building a digital twin of EDFA: a grey-box modeling approach

To enable intelligent and self-driving optical networks, high-accuracy physical layer models are required. The dynamic wavelength-dependent gain effects of non-constant-pump erbium-doped fiber amplifiers (EDFAs) remain a crucial problem in terms of modeling, as it determines optical-to-signal noise ratio as well as the magnitude of fiber nonlinearities. Black-box data-driven models have been widely studied, but it requires a large size of data for training and suffers from poor generalizability. In this paper, we derive the gain spectra of EDFAs as a simple univariable linear function, and then based on it we propose a grey-box EDFA gain modeling scheme. Experimental results show that for both automatic gain control (AGC) and automatic power control (APC) EDFAs, our model built with 8 data samples can achieve better performance than the neural network (NN) based model built with 900 data samples, which means the required data size for modeling can be reduced by at least two orders of magnitude. Moreover, in the experiment the proposed model demonstrates superior generalizability to unseen scenarios since it is based on the underlying physics of EDFAs. The results indicate that building a customized digital twin of each EDFA in optical networks become feasible, which is essential especially for next generation multi-band network operations