125 research outputs found
B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population
© 2009 Zhang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Tissue engineering rib with the incorporation of biodegradable polymer cage and BMSCs/decalcified bone: an experimental study in a canine model
FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity
Characterization by Suppression Subtractive Hybridization of Transcripts That Are Differentially Expressed in Leaves of Anthracnose-Resistant Ramie Cultivar
MiR-218 Inhibits Invasion and Metastasis of Gastric Cancer by Targeting the Robo1 Receptor
MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased along with the expression of one of its host genes, Slit3 in metastatic GC. However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis. The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in vitro and in vivo. Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis
Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma
Identification and expression of the WRKY transcription factors of Carica papaya in response to abiotic and biotic stresses
Effect of grain size distribution of sandy soil on shearing behaviors at soil-structure interface
Title on author’s file: "Effect of grain size distribution of sandy soil on the shearing behaviors at soil-structure interface"202310 bcchAccepted ManuscriptRGCOthersScience and Technology Development Fund, Macao S.A.R; National Natural Science Foundation of China; the University of Macau Research FundPublishe
Preparation and application of yellow fever virus NS1 protein‐specific monoclonal antibodies
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