Rapidity bin multiplicity correlations from a multi-phase transport model

The central-arbitrary bin and forward-backward bin multiplicity correlation patterns for Au+Au collisions at $\sqrt{s_{NN}}$= $7.7-62.4$ GeV are investigated within a multi-phase transport (AMPT) model. An interesting observation is that for $\sqrt{s_{NN}} <19.6$ GeV Au+Au collisions, these two correlation patterns both have an increase with the pseudorapidity gap, while for $\sqrt{s_{NN}} >19.6$ GeV Au+Au collisions, they decrease. We mainly discuss the influence of different evolution stages of collision system on the central-arbitrary bin correlations, such as the initial conditions, partonic scatterings, hadronization scheme and hadronic scatterings. Our results show that the central-arbitrary bin multiplicity correlations have different responses to partonic phase and hadronic phase, which can be suggested as a good probe to explore the dynamical evolution mechanism of the hot dense matter in high-energy heavy-ion collisions.Comment: 7pages, 6 figures, accepted for publication in EPJ

Relationship Among Customer Value, Satisfaction, And Loyalty of Social Network Service

Social Network Service (SNS), is an innovative application and business model in recent years. It changes the development and communication of current social network and gathers tremendous viewers to create more business opportunities. However, what are the values that attract users to use SNS? This study focuses on the behaviors of SNS users in Taiwan by empirical research. From the customer point of view, satisfaction and loyalty could be relative to and affected by utilitarian value and hedonic value. Therefore, this study builds an applicable integrated model and uses Structural Equation Modeling to analyze the relations of constructs in the model. We find the following. (1) The constructs of the model are supported. (2) The utilitarian value can be measured by factors of sociality, convenience, and information availability; hedonic value can be measured by factors of adventure, escapism, and affiliation. (3) The utilitarian value and hedonic value affect customer satisfaction; customer satisfaction affects word of mouth and repatronage intention. (4) The utilitarian value and hedonic value positively affect word of mouth and repatronage intention, but providing a good customer satisfaction can enhance word of mouth and repatronage intention. (5) The influence of hedonic value is higher than that of utilitarian value

(6aS,11aR,11cS)-8-Sulfanylidene-2,3,5,6,6a,7,11,11a,11b,11c-decahydro-3a,7a-diaza-1H,4H-benzo[de]anthracen-3a-ium chloride hemihydrate

The title compound, C15H23N2S+·Cl−·0.5H2O, was prepared from (6aS,11aR,11cS)-2,3,5,6,6a,7,11,11a,11b,11c-deca­hydro-3a,7a-diaza-1H,4H-benzo[de]anthracene-8-one (sophocarpine) and Lawesson’s reagent. The thione-substituted ring is in an envelope conformation and the three other six-membered rings are in chair conformations. In the crystal, anions and cations are linked by N—H⋯Cl and weak C—H⋯Cl hydrogen bonds. One 0.5-occupancy solvent water mol­ecule lies on a twofold rotation axis and another 0.25-occupancy solvent water mol­ecule is in a general position. The H atoms of these water mol­ecules were not located or included in the refinement

Progressive decay of Ca2+ homeostasis in the development of diabetic cardiomyopathy

BACKGROUND: Cardiac dysfunction in diabetic cardiomyopathy may be associated with abnormal Ca(2+) homeostasis. This study investigated the effects of alterations in Ca(2+) homeostasis and sarcoplasmic reticulum Ca(2+)-associated proteins on cardiac function in the development of diabetic cardiomyopathy. METHODS: Sprague–Dawley rats were divided into 4 groups (n = 12, each): a control group, and streptozotocin-induced rat models of diabetes groups, examined after 4, 8, or 12 weeks. Evaluations on cardiac structure and function were performed by echocardiography and hemodynamic examinations, respectively. Cardiomyocytes were isolated and spontaneous Ca(2+) spark images were formed by introducing fluorescent dye Fluo-4 and obtained with confocal scanning microscopy. Expressions of Ca(2+)-associated proteins were assessed by Western blotting. RESULTS: Echocardiography and hemodynamic measurements revealed that cardiac dysfunction is associated with the progression of diabetes, which also correlated with a gradual but significant decline in Ca(2+) spark frequency (in the 4-, 8- and 12-week diabetic groups). However, Ca(2+) spark decay time constants increased significantly, relative to the control group. Expressions of ryanodine receptor 2 (RyR2), sarcoplasmic reticulum Ca(2+)-2ATPase (SERCA) and Na(+)/Ca(2+) exchanger (NCX1) were decreased, together with quantitative alterations in Ca(2+)regulatory proteins, FKBP12.6 and phospholamban progressively and respectively in the diabetic rats. CONCLUSIONS: Ca(2+) sparks exhibited a time-dependent decay with progression of diabetic cardiomyopathy, which may partly contribute to cardiac dysfunction. This abnormality may be attributable to alterations in the expressions of some Ca(2+)-associated proteins

Estrogen receptor β2 and β5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion

Estrogens play a pivotal role in the development and progression of prostate cancer (PCa). Their actions are mediated by estrogen receptors (ERs), particularly ERβ in the prostate epithelium. With the discovery of ERβ isoforms, data from previous studies that focused principally on the wild-type ERβ (ERβ1) may not be adequate in explaining the still controversial role of ERβ(s) in prostate carcinogenesis. In this study, using newly generated isoform-specific antibodies, immunohistochemistry (IHC) was performed on a tumor microarray comprised of 144 specimens. IHC results were correlated with pathological and clinical follow-up data to delineate the distinct roles of ERβ1, ERβ2, and ERβ5 in PCa. ERβ2 was commonly found in the cytoplasm and was the most abundant isoform followed by ERβ1 localized predominantly in the nucleus, and ERβ5 was primarily located in the cytoplasm. Logistic regression analyses demonstrated that nuclear ERβ2 (nERβ2) is an independent prognostic marker for prostate specific antigen (PSA) failure and postoperative metastasis (POM). In a Kaplan–Meier analysis, the combined expression of both nERβ2 and cytoplasmic ERβ5 identified a group of patients with the shortest POM-free survival. Cox proportional hazard models revealed that nERβ2 predicted shorter time to POM. In concordance with IHC data, stable, ectopic expression of ERβ2 or ERβ5 enhanced PCa cell invasiveness but only PCa cells expressing ERβ5 exhibited augmented cell migration. This is the first study to uncover a metastasis-promoting role of ERβ2 and ERβ5 in PCa, and show that the two isoforms, singularly and conjointly, have prognostic values for PCa progression. These findings may aid future clinical management of PCa