RELIABILITY OF CLINICAL ISOKINETIC DYNAMOMETRY IN PATHOLOGICAL ATHLETIC SHOULDERS

There have been relatively few studies of the reliability of isokinetic shoulder testing, and only Malerba et al. (1993) have investigated patients with shoulder joint pathology (patients ranged in activity level from sedentary to highly active). Furthermore, all existing studies have involved a level of procedural standardisation which, while desirable, cannot always be achieved in a clinical environment, that is, where most isokinetic testing is performed. Therefore, the aim of this study was to assess the reliability of isokinetic testing of pathological athletic shoulders in a clinical environment, under routine clinical conditions. Twenty-two athletic patients (mean age 26 years) presenting with a range of pathologies including post-subluxation, post-dislocation, and post-surgical reconstruction were tested. Patients were tested on two occasions, separated by a time interval during which their clinical status was not expected to change (most tests were one week apart; mean interval 10 days). Bilateral isokinetic strength of the shoulder internal and external rotators were tested on a Cybex 6000 dynamometer at 2.09 and 4.19 radianslsecond (concentric) and 2.09 radianslsecond (eccentric). Patients were tested in a seated position, in 45 degrees of shoulder abduction, and 90 degrees of elbow flexion. Tests were performed in essentially the same fashion on each occasion by the same tester. However, the constraints of a busy clinical environment meant that precise control and exact replication may not have always been achieved. Intra-class correlation coefficients (ICC) for absolute concentric peak torque, work, and average power were all above 0.9. Eccentric ICCs were generally above 0.8. These values are as high as, or higher than, those reported in the literature for studies of healthy subjects conducted under more stringent conditions than can be achieved in a clinical environment. The reliability of commonly calculated ratios, such as agonistlantagonist and involved/uninvolved, was lower than that of the constituent absolute scores, and in some cases were quite poor. Caution is therefore warranted in the use of such ratios. Malerba JL; Adam ML, Harris BA, Krebs DE (1993) Reliability of dynamic and isometric testing of shoulder external and internal rotators. Journal of Orthopaedic and Sports Physical Therapy 18543-552

Nowhere to Hide: Radio-faint AGN in the GOODS-N field. I. Initial catalogue and radio properties

(Abridged) Conventional radio surveys of deep fields ordinarily have arc-second scale resolutions often insufficient to reliably separate radio emission in distant galaxies originating from star-formation and AGN-related activity. Very long baseline interferometry (VLBI) can offer a solution by identifying only the most compact radio emitting regions in galaxies at cosmological distances where the high brightness temperatures (in excess of $10^5$ K) can only be reliably attributed to AGN activity. We present the first in a series of papers exploring the faint compact radio population using a new wide-field VLBI survey of the GOODS-N field. The unparalleled sensitivity of the European VLBI Network (EVN) will probe a luminosity range rarely seen in deep wide-field VLBI observations, thus providing insights into the role of AGN to radio luminosities of the order $10^{22}~\mathrm{W\,Hz^{-1}}$ across cosmic time. The newest VLBI techniques are used to completely cover an entire 7'.5 radius area to milliarcsecond resolutions, while bright radio sources ($S > 0.1$ mJy) are targeted up to 25 arcmin from the pointing centre. Multi-source self-calibration, and a primary beam model for the EVN array are used to correct for residual phase errors and primary beam attenuation respectively. This paper presents the largest catalogue of VLBI detected sources in GOODS-N comprising of 31 compact radio sources across a redshift range of 0.11-3.44, almost three times more than previous VLBI surveys in this field. We provide a machine-readable catalogue and introduce the radio properties of the detected sources using complementary data from the e-MERLIN Galaxy Evolution survey (eMERGE).Comment: 15 pages, 8 figures, accepted in A&A. Machine-readable table available upon reques

Distinct patterns of thought mediate the link between brain functional connectomes and well-being

Ongoing thought patterns constitute important aspects of both healthy and abnormal human cognition. However, the neural mechanisms behind these daily experiences and their contribution to well-being remain a matter of debate. Here, using resting-state fMRI and retrospective thought sampling in a large neurotypical cohort (n = 211), we identified two distinct patterns of thought, broadly describing the participants’ current concerns and future plans, that significantly explained variability in the individual functional connectomes. Consistent with the view that ongoing thoughts are an emergent property of multiple neural systems, network-based analysis highlighted the central importance of both unimodal and transmodal cortices in the generation of these experiences. Importantly, while state-dependent current concerns predicted better psychological health, mediating the effect of functional connectomes, trait-level future plans were related to better social health, yet with no mediatory influence. Collectively, we show that ongoing thoughts can influence the link between brain physiology and well-being

Signal peptide peptidases and gamma-secretase: Cousins of the same protease family?

Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, which provide the proteolytically active subunit of the,gamma-secretase complex, SPP contains a conserved GxGD motif in its C-terminal domain which is critical for its activity. While SPIP is known to be an aspartyl protease of the GxGD type, several presenilin homologues/SPP-like proteins (PSHs/ SPPL) of unknown function have been identified by database searches. In contrast to SPP and SPPL3, which are both restricted to the endoplasmic reticulum, SPPL2b is targeted through the secretory pathway to endosomes/lysosomes. As suggested by the differential subcellular localization of SPPL2b and SPPL3 distinct phenotypes were found upon antisense gripNA-mediated knockdown in zebrafish. spp and sppl3 knockdowns in zebrafish result in cell death within the central nervous system, whereas reduction of sppl2b expression causes erythrocyte accumulation in an enlarged caudal vein. Moreover, expression of D/A mutants of the putative C-terminal active sites of spp, sppl2, and spp13 produced phenocopies of the respective knockdown phenotypes. These data suggest that all investigated PSHs/SPPLs are members of the novel family of GxGD aspartyl proteases. More recently, it was shown that SPPL2b utilizes multiple intramembrane cleavages to liberate the TNF(x intracellular domain into the cytosol and to release the C-terminal counterpart into the lumen. These findings suggest common principles of intramembrane proteolysis by GxGD type aspartyl proteases. In this article,we will review the similarities of SPPs and gamma-secretase based on recent findings by us and others

Retailing in the United Kingdom - a synopsis

This paper illustrates the structure of, and trends in, the retail market of the United Kingdom (UK). This industry analysis describes the retail environment compared to continental Europe and considers the regulatory issues which have helped form this retail environment. By using secondary data we describe concentration and consolidation tendencies and explain specific features of the UK retail market. Major trends are identified and discussed, concluding with an outlook on future developments