Explaining how and explaining why: developmental and evolutionary explanations of dominance

There have been two different schools of thought on the evolution of dominance. On the one hand, followers of Wright [Wright S. 1929. Am. Nat. 63: 274–279, Evolution: Selected Papers by Sewall Wright, University of Chicago Press, Chicago; 1934. Am. Nat. 68: 25–53, Evolution: Selected Papers by Sewall Wright, University of Chicago Press, Chicago; Haldane J.B.S. 1930. Am. Nat. 64: 87–90; 1939. J. Genet. 37: 365–374; Kacser H. and Burns J.A. 1981. Genetics 97: 639–666] have defended the view that dominance is a product of non-linearities in gene expression. On the other hand, followers of Fisher [Fisher R.A. 1928a. Am. Nat. 62: 15–126; 1928b. Am. Nat. 62: 571– 574; Bu¨ rger R. 1983a. Math. Biosci. 67: 125–143; 1983b. J. Math. Biol. 16: 269–280; Wagner G. and Burger R. 1985. J. Theor. Biol. 113: 475–500; Mayo O. and Reinhard B. 1997. Biol. Rev. 72: 97– 110] have argued that dominance evolved via selection on modifier genes. Some have called these ‘‘physiological’’ versus ‘‘selectionist,’’ or more recently [Falk R. 2001. Biol. Philos. 16: 285–323], ‘‘functional,’’ versus ‘‘structural’’ explanations of dominance. This paper argues, however, that one need not treat these explanations as exclusive. While one can disagree about the most likely evolutionary explanation of dominance, as Wright and Fisher did, offering a ‘‘physiological’’ or developmental explanation of dominance does not render dominance ‘‘epiphenomenal,’’ nor show that evolutionary considerations are irrelevant to the maintenance of dominance, as some [Kacser H. and Burns J.A. 1981. Genetics 97: 639–666] have argued. Recent work [Gilchrist M.A. and Nijhout H.F. 2001. Genetics 159: 423–432] illustrates how biological explanation is a multi-level task, requiring both a ‘‘top-down’’ approach to understanding how a pattern of inheritance or trait might be maintained in populations, as well as ‘‘bottom-up’’ modeling of the dynamics of gene expression

Book Reviews

Book Review 1Book Title: Clinical Echo-EncephalographyBook Authors: W. Sehiefer, E. Kazner,  S. Kunze & translated by M. KlingerM.D. Pp. ix + 224. Illustrated. £5.5.0. Bristol: John Wright & Sons. 1968.Book Review 2Book Title:  Medical Thermography. Proceedings of a Boerhaave Course for Postgraduate Medical Education, given in collaboration with the Netherlands' Society of Radiology, Leiden, in March 1968Pp. viii + 23. Illustrated. £6.10.0. Basle and New York: S. Karger. 1969Book Review 3Book Title: Recent Advances in Paediatric Clinical PathologyBook Authors: C.C. Mabry, I.E. Roeckel, R.E. Gevedon & J.A. KoepkePp. viii + 246. Illustrated. $14.50. New York and London: Grune & Stratton. 1968.Book Review 4Book Title: Clinical Aspects of Immunology. 2nd ed.Book Authors: P.G.H. Gell & R.R.A. CoombsPp. xxix + 1356. Illustrated. £7.10.0. Oxford: Blackwell Scientific Publications. 1968

Explaining how and explaining why: developmental and evolutionary explanations of dominance

There have been two different schools of thought on the evolution of dominance. On the one hand, followers of Wright [Wright S. 1929. Am. Nat. 63: 274–279, Evolution: Selected Papers by Sewall Wright, University of Chicago Press, Chicago; 1934. Am. Nat. 68: 25–53, Evolution: Selected Papers by Sewall Wright, University of Chicago Press, Chicago; Haldane J.B.S. 1930. Am. Nat. 64: 87–90; 1939. J. Genet. 37: 365–374; Kacser H. and Burns J.A. 1981. Genetics 97: 639–666] have defended the view that dominance is a product of non-linearities in gene expression. On the other hand, followers of Fisher [Fisher R.A. 1928a. Am. Nat. 62: 15–126; 1928b. Am. Nat. 62: 571– 574; Bu¨ rger R. 1983a. Math. Biosci. 67: 125–143; 1983b. J. Math. Biol. 16: 269–280; Wagner G. and Burger R. 1985. J. Theor. Biol. 113: 475–500; Mayo O. and Reinhard B. 1997. Biol. Rev. 72: 97– 110] have argued that dominance evolved via selection on modifier genes. Some have called these ‘‘physiological’’ versus ‘‘selectionist,’’ or more recently [Falk R. 2001. Biol. Philos. 16: 285–323], ‘‘functional,’’ versus ‘‘structural’’ explanations of dominance. This paper argues, however, that one need not treat these explanations as exclusive. While one can disagree about the most likely evolutionary explanation of dominance, as Wright and Fisher did, offering a ‘‘physiological’’ or developmental explanation of dominance does not render dominance ‘‘epiphenomenal,’’ nor show that evolutionary considerations are irrelevant to the maintenance of dominance, as some [Kacser H. and Burns J.A. 1981. Genetics 97: 639–666] have argued. Recent work [Gilchrist M.A. and Nijhout H.F. 2001. Genetics 159: 423–432] illustrates how biological explanation is a multi-level task, requiring both a ‘‘top-down’’ approach to understanding how a pattern of inheritance or trait might be maintained in populations, as well as ‘‘bottom-up’’ modeling of the dynamics of gene expression

Fecal contamination of drinking-water in low- and middle-income countries: a systematic review and meta-analysis

Background: access to safe drinking-water is a fundamental requirement for good health and is also a human right. Global access to safe drinking-water is monitored by WHO and UNICEF using as an indicator “use of an improved source,” which does not account for water quality measurements. Our objectives were to determine whether water from “improved” sources is less likely to contain fecal contamination than “unimproved” sources and to assess the extent to which contamination varies by source type and setting.Methods and findings: studies in Chinese, English, French, Portuguese, and Spanish were identified from online databases, including PubMed and Web of Science, and grey literature. Studies in low- and middle-income countries published between 1990 and August 2013 that assessed drinking-water for the presence of Escherichia coli or thermotolerant coliforms (TTC) were included provided they associated results with a particular source type. In total 319 studies were included, reporting on 96,737 water samples. The odds of contamination within a given study were considerably lower for “improved” sources than “unimproved” sources (odds ratio [OR] = 0.15 [0.10–0.21], I2 = 80.3% [72.9–85.6]). However over a quarter of samples from improved sources contained fecal contamination in 38% of 191 studies. Water sources in low-income countries (OR = 2.37 [1.52–3.71]; p<0.001) and rural areas (OR = 2.37 [1.47–3.81] p<0.001) were more likely to be contaminated. Studies rarely reported stored water quality or sanitary risks and few achieved robust random selection. Safety may be overestimated due to infrequent water sampling and deterioration in quality prior to consumption.Conclusion: access to an “improved source” provides a measure of sanitary protection but does not ensure water is free of fecal contamination nor is it consistent between source types or settings. International estimates therefore greatly overstate use of safe drinking-water and do not fully reflect disparities in access. An enhanced monitoring strategy would combine indicators of sanitary protection with measures of water qualit

Molecular techniques reveal cryptic life history and demographic processes of a critically endangered marine turtle

The concept of ‘effective population size’ (Ne), which quantifies how quickly a population will lose genetic variability, is one of the most important contributions of theoretical evolutionary biology to practical conservation management. Ne is often much lower than actual population size: how much so depends on key life history and demographic parameters, such as mating systems and population connectivity, that often remain unknown for species of conservation concern. Molecular techniques allow the indirect study of these parameters, as well as the estimation of current and historical Ne. Here, we use genotyping to assess the genetic health of an important population of the critically endangered hawksbill turtle (Eretmochelys imbricata), a slow-to-mature, difficult-to-observe species with a long history of severe overhunting. Our results were surprisingly positive: we found that the study population, located in the Republic of Seychelles, Indian Ocean, has a relatively large Ne, estimated to exceed 1000, and showed no evidence of a recent reduction in Ne (i.e. no genetic bottleneck). Furthermore, molecular inferences suggest the species' mating system is conducive to maintaining a large Ne, with a relatively large and widely distributed male population promoting considerable gene flow amongst nesting sites across the Seychelles area. This may also be reinforced by the movement of females between nesting sites. Our study underlines how molecular techniques can help to inform conservation biology. In this case our results suggest that this important hawksbill population is starting from a relatively strong position as it faces new challenges, such as global climate change

Evolutionary Synthesis of HVAC System Configurations: Algorithm Development.

This paper describes the development of an optimization procedure for the synthesis of novel heating, ventilating, and air-conditioning (HVAC) system configurations. Novel HVAC system designs can be synthesized using model-based optimization methods. The optimization problem can be considered as having three sub-optimization problems; the choice of a component set; the design of the topological connections between the components; and the design of a system operating strategy. In an attempt to limit the computational effort required to obtain a design solution, the approach adopted in this research is to solve all three sub-problems simultaneously. Further, the computational effort has been limited by implementing simplified component models and including the system performance evaluation as part of the optimization problem (there being no need in this respect to simulation the system performance). The optimization problem has been solved using a Genetic Algorithm (GA), with data structures and search operators that are specifically developed for the solution of HVAC system optimization problems (in some instances, certain of the novel operators may also be used in other topological optimization problems. The performance of the algorithm, and various search operators has been examined for a two-zone optimization problem (the objective of the optimization being to find a system design that minimizes the system energy use). In particular, the performance of the algorithm in finding feasible system designs has been examined. It was concluded that the search was unreliable when the component set was optimized, but if the component set was fixed as a boundary condition on the search, then the algorithm had an 81% probability of finding a feasible system design. The optimality of the solutions is not examined in this paper, but is described in an associated publication. It was concluded that, given a candidate set of system components, the algorithm described here provides an effective tool for exploring the novel design of HVAC systems. (c) HVAC & R journa

Pseudacris ornata

Number of Pages: 8Integrative BiologyGeological Science

Chionactis palarostris

Number of Pages: 5Integrative BiologyGeological Science

The Isolation of an Actinomycetes-Like Organism from Root Canals

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67354/2/10.1177_00220345410200030301.pd