Metalen gebruiksvoorwerpen uit de late Bronstijd uit de Maasvallei: een analytische en metallurgische benadering van de depots van Dilsen en Maaseik-Heppeneert

De interesse voor de samenstelling van oude metalen heeft een geschiedenis die bijna even lang is als deze van de analytische chemie zelf. Reeds op het einde van de 18de eeuw publiceerde Martin Klaproth, de \u27vader van de analytische scheikunde\u27, de analyseresultaten van Romeinse spiegels en ander archeologisch metaalwerk. Gedurende de 20ste eeuw, met de uitvinding van de instrumentele analytische technieken, zoals de spectrografie, werd routine-analyse mogelijk en werden grote onderzoeksprojecten opgestart waarbij honderden en zelfs duizenden monsters betrokken werden. Door toepassing van onder meer de spectrografie kon bij een aanvaardbare kleine monsterhoeveelheid een zeer gevoelige detectielimiet bereikt worden. Hieruit groeide de interesse voor de bepaling van de sporenelementen die in het metaalwerk aanwezig zijn. Deze determinatie geeft inzichten in de bekwaamheid van de prehistorische smeden om hun metalen te zuiveren en in de oorsprong van de metalen die ze verwerkten

Chapter 1 Introduction

Digital technologies shape our embodied lives and affect our knowledge of the self and the world. The introductory chapter of the book presents the state of the art in the research on digitalisation of health and social care work, with a focus on care for older people. In ageing societies, understanding what it takes to introduce and use digital technologies can pave the way to a successful, sustainable, and equally accessible system of social care and healthcare provision for older people. The chapter discusses some of the limitations in the present discussion and how the book at hand aims to address these gaps. The chapter proposes that living in an increasingly digitalised world requires digital agency, that is the individual’s ability to control and adapt to their surroundings, and to critically address technological determinism in the everyday life. The chapter ends with an overview of the book’s subsequent chapters that demonstrate different aspects to service users’ and care workers’ digital agency based on recent studies of digital technologies in care for older people

Chapter 1 Introduction

Digital technologies shape our embodied lives and affect our knowledge of the self and the world. The introductory chapter of the book presents the state of the art in the research on digitalisation of health and social care work, with a focus on care for older people. In ageing societies, understanding what it takes to introduce and use digital technologies can pave the way to a successful, sustainable, and equally accessible system of social care and healthcare provision for older people. The chapter discusses some of the limitations in the present discussion and how the book at hand aims to address these gaps. The chapter proposes that living in an increasingly digitalised world requires digital agency, that is the individual’s ability to control and adapt to their surroundings, and to critically address technological determinism in the everyday life. The chapter ends with an overview of the book’s subsequent chapters that demonstrate different aspects to service users’ and care workers’ digital agency based on recent studies of digital technologies in care for older people

De Colorando Auro: Medieval colouring techniques researched using modern analytical techniques

The visual appearance of gold and gilding can be influenced in many ways, such as by changing the composition of the gold alloy or the nature of the gilded substrate. A less known medieval technique, reported in historical treatises, is the chemical treatment of the gilded surface itself, after application and burnishing of the gilding. We reporte here results regarding the study of the Holy Lady Shrine of Huy (13th c AD Mosan, Belgium) on which a possible artificial colouration of the gildings was detected. This led to many questions regarding applicable conservation-restoration treatments. Here is an overview of the results obtained, along with a discussion of the methodology that was developed to study this colouration process, also highlighting the necessary complementarity between laboratory and synchrotron-based analytical approaches. The 3-steps methodology proposed in this paper is generic for most cultural heritage problems where the application of ancient surface modification recipes is suspected but where the scarcity of the historical samples does not allow a direct study of such samples.L’aspect visuel de l’or et des dorures peut être modifié de diverses manières, notamment en changeant la composition de l’alliage ou la nature du support doré. Une technique médiévale moins connue, évoquée dans les traités anciens, consiste à provoquer une réaction chimique après application et brunissage de la dorure. Les recherches sur la châsse de Notre-Dame de Huy (art mosan du xiiie siècle) ont révélé une possible coloration artificielle des dorures. Cette découverte soulève de nombreuses questions quant aux traitements de conservation-restauration utilisables. Nous présentons ici un exposé sommaire des résultats obtenus ainsi qu’un compte rendu de la méthode mise au point pour étudier ce procédé de coloration, en soulignant la complémentarité indispensable entre les examens de laboratoire et l’analyse par rayonnement synchrotron. Dans les sciences du patrimoine culturel, cette méthode en trois temps concerne la plupart des situations où une recette ancienne semble avoir été employée pour modifier la surface, mais où la rareté des échantillons historiques ne permet pas l’étude directe de sous-échantillons

Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Therapeutic approaches in the treatment of juvenile dermatomyositis in patients with recent-onset disease and in those experiencing disease flare: An international multicenter PRINTO study

Objective To evaluate response to therapy over a 24-month period in a large prospective international cohort of patients with juvenile dermatomyositis (DM). Methods The study included 145 patients with recent-onset juvenile DM and 130 juvenile DM patients experiencing disease flare, all of whom were \u3c18 years old. Disease activity parameters and therapeutic approaches in 4 geographic areas were analyzed at baseline and at 6, 12, and 24 months. Response was assessed according to the Pediatric Rheumatology International Trials Organization (PRINTO) juvenile DM response criteria, and data were reported as observed and in the intent-to-treat (ITT) population. Results Patients with recent-onset juvenile DM at baseline had higher baseline disease activity and greater improvement over 24 months when compared to juvenile DM patients experiencing disease flare at baseline. Methotrexate (MTX) or high-dose corticosteroids were administered more frequently to patients with recent-onset juvenile DM, compared to juvenile DM patients experiencing disease flare, who were more likely to receive cyclosporine. Compared to patients from Western and Eastern Europe, a higher proportion of patients from South and Central America and North America received pulse steroids, and the average steroid dosage was higher in the North American and South and Central American patients. The use of MTX was similar in all 4 regions, while cyclosporin A was more frequently used in Western Europe. In the as observed analysis, 57.9% of the patients with recent-onset juvenile DM and 36.4% of the patients experiencing disease flare (P \u3c 0.001) reached at least a 70% response by PRINTO criteria at 6 months; these proportions had increased at month 24 to 78.4% and 51.2%, respectively (P \u3c 0.001). Corresponding results of the ITT analysis were much lower, with only one-third of the patients able to maintain the initial assigned therapy over 24 months. Conclusion Patients with recent-onset juvenile DM are more likely to achieve significant clinical improvement over 24 months, when compared to patients experiencing flares of juvenile DM. Internationally, various therapeutic approaches are used to treat this disease. Copyright © 2011 by the American College of Rheumatology

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Typologie, technologie et consommation des fibules émaillées en Gaule Belgique et Germanie :méthodologie et résultats préliminaires

info:eu-repo/semantics/nonPublishe

Metal Composition of Roman Enamellled Brooches in Gallia Belgica and Germania Inferior

info:eu-repo/semantics/nonPublishe

Elementary Analysis of Roman Enamelled Brooches of Gallia Belgica and Germania :Preliminary results

info:eu-repo/semantics/nonPublishe