Public Value Energy Governance: establishing an institutional framework which better fits a sustainable, secure and affordable energy system

This short Discussion Paper is intended to stimulate discussion about how governance of the energy system in Britain can better keep up with technological, economic and social change. We have set out a possible model for future governance and regulation – which moves from the ‘independent, CEO led’ model currently in Britain to one which is more ‘directed’ and which we argue is more legitimate, transparent and nimble; but which also better suits the characteristics of current technologies (whether supply, demand, storage and ICT integration). We would welcome comments on it by the end of June 2015. Whatever the optimum model for future energy system governance and regulation, though, the fundamental point remains: the current model of regulation in the UK’s gas and electricity systems is no longer fit for purpose

Core health promotion competencies for Australia 2007

Four hundred health promotion practitioners throughout Australian completed an on-line survey on Health Promotion Competencies for Australia at the end of 2005. This was followed by a series of workshops throughout Australia in 2006 to identify practical uses of the competencies and to determine a set of core competencies of health promotion practice in Australia. Many of the participants requested information about the results of the study. This brief report has been produced to describe the process and the final result. In addition more detailed accounts are contained in two articles that are being prepared for publication

Physiological Measures of Risk Perception in Highly Automated Driving

Highly automated driving will likely result in drivers being out-of-the-loop during specific scenarios and engaging in a wide range of non-driving related tasks. Manifesting in lower levels of risk perception to emerging events, and thus affect drivers' availability to take-over manual control in safety-critical scenarios. In this empirical research, we measured drivers' (N = 20) risk perception with cardiac and skin conductance indicators through a series of high-fidelity, simulated highly automated driving scenarios. By manipulating the presence of surrounding traffic and changing driving conditions as long-term risk modulators, and including a driving hazard event as a short-term risk modulator, we hypothesised that an increase in risk perception would induce greater physiological arousal. Our results demonstrate that heart rate variability features are superior at capturing arousal variations from these long-term, low to moderate risk scenarios. In contrast, skin conductance responses are more sensitive to rapidly evolving situations associated with moderate to high risk. Based on this research, future driver state monitoring systems should adopt multiple physiological measures to capture changes in the long and short term, modulation of risk perception. This will enable enhanced perception of driver readiness and improved availability to safely deal with take-over events when requested by an automated vehicle.</p

Bound on Lorentz- and CPT-Violating Boost Effects for the Neutron

A search for an annual variation of a daily sidereal modulation of the frequency difference between co-located ${}^{129}$Xe and ${}^{3}$He Zeeman masers sets a stringent limit on boost-dependent Lorentz and CPT violation involving the neutron, consistent with no effect at the level of 150 nHz. In the framework of the general Standard-Model Extension, the present result provides the first clean test for the fermion sector of the symmetry of spacetime under boost transformations at a level of $10^{-27}$ GeV.Comment: 4 pages, 1 figur

Topical steroid therapy for the treatment of eosinophilic esophagitis (EoE): a systematic review and meta-analysis

OBJECTIVES: Current guidelines recommend topical steroids as first-line treatment for patients with eosinophilic esophagitis (EoE). However, the evidence for this approach has been inconsistent in earlier reports. This meta-analysis aimed to clarify the efficacy of topical steroid treatment in active EoE using updated evidence. METHODS: CENTRAL, MEDLINE and EMBASE databases were searched for randomized controlled trials (RCTs) published up to May 2014 that compared topical steroids with control treatments for active EoE. Study bias was assessed using the Cochrane Collaboration Tool, and outcomes were pooled using random effects models. The primary outcome was the mean change in eosinophil counts. Secondary outcomes were symptom responses and adverse events. RESULTS: In total, seven RCTs (226 patients) were included. Topical steroids were associated with a significant reduction in esophageal mucosal eosinophil counts compared with control therapy although substantial heterogeneity between studies was observed (weighted mean difference (WMD) −27.2, 95% confidence interval (CI) − 45.3 to −9.1, I2=56.2%). Subgroup analysis indicated the reduction in eosinophil counts was only present in studies where a proton pump inhibitor (PPI) trial was used to exclude other diagnoses (WMD −46.3, 95% CI − 61.3 to − 31.4, I2=0.0%). Subdivision of studies on the use of a PPI trial also accounted for the majority of heterogeneity among RCTs. No clear trends in symptom resolution were observed. Eleven out of 127 patients who received topical steroids developed asymptomatic esophageal candidiasis. CONCLUSIONS: These data provide updated high-quality evidence that support current guidelines for first-line EoE treatment with topical steroids after an initial PPI trial to exclude non-EoE pathologies (PROSPERO ID: CRD42014008828).Ming-yu (Anthony) Chuang, Mohamed A. Chinnaratha, David G. Hancock, Richard Woodman, Geoffrey R. Wong, Charles Cock, and Robert JL. Frase

Human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix.

The polymerase chain reaction has been used to determine the presence of human papillomavirus (HPV) 16 and HPV 18 DNA sequences in archival histological material removed from a cohort of untreated women with cervical epithelial abnormalities. The detection of HPV 16 or HPV 18 DNA sequences in the initial biopsy specimen was associated with a significantly increased risk of subsequent disease progression

Protocol for developing core outcome sets for evaluation of psychosocial interventions for children and families with experience or at risk of child maltreatment or domestic abuse

Introduction Recognition that child maltreatment (CM) and domestic violence and abuse (DVA) are common and have serious and long-term adverse health consequences has resulted in policies and programmes to ensure that services respond to and safeguard children and their families. However, high-quality evidence about how services can effectively intervene is scant. The value of the current evidence base is limited partly because of the variety of outcomes and measures used in evaluative studies. One way of addressing this limitation is to develop a core outcome set (COS) which is measured and reported as a minimum standard in the context of trials and other types of evaluative research. The study described in this protocol aims to develop two discrete COSs for use in future evaluation of psychosocial interventions aimed at improving outcomes for children and families at risk or with experience of (1) CM or (2) DVA. Methods and analysis A two-phase mixed methods design: (1) rapid reviews of evidence, stakeholder workshops and semistructured interviews with adult survivors of CM/DVA and parents of children who have experienced CM/DVA and (2) a three panel adapted E-Delphi Study and consensus meeting. This study protocol adheres to reporting guidance for COS protocols and has been registered on the Core Outcome Measures for Effectiveness Trials (COMET) database. Ethics and dissemination We will disseminate our findings through peer-reviewed and open access publications, the COMET website and presentations at international conferences. We will engage with research networks, journal editors and funding agencies to promote awareness of the CM-COS and DVA-COS. We will work with advisory and survivor and public involvement groups to coproduce a range of survivor, policy and practice facing outputs. Approval for this study has been granted by the Research Ethics Committee at University College London

Towards quality control in cancer chemotherapy.

A survey of all hospital pharmacies in the former North Western Regional Health Authority has revealed that hospital personnel continue to prepare cytotoxic drugs in suboptimal conditions, despite the widespread introduction of pharmacy cytotoxic reconstitution services. Other concerns include the lack of formal training for medical staff in the administration of these agents and the frequent absence of written procedures for dealing with extravasation and chemotherapy errors

Domestic thermal upgrades, community action and energy saving: a three-year experimental study of prosperous households

A three-year field experiment was conducted with 185 prosperous households to assess whether behavioural interventions by a community environmental group during and after thermal upgrades (cavity wall and/or loft insulation) can achieve reductions in households’ energy use, including reductions in direct and indirect rebound. The engineering interventions on the thermal efficiency of dwellings appear effective in reducing energy use in both treatment and control groups: a direct rebound effect is estimated to be at most 40 per cent from the engineering interventions. However, across a range of measures of energy use, we observe no significant effect of the community behavioural intervention across the total lifetime of the project. Qualitative data collected on similar community groups suggests substantial constraints on their capacity to realise reductions in energy use amongst households

Characterization of envelope function of transmitted viruses circulating in Mbeya, Tanzania, and its impact on disease progression

An understanding of the biological characteristics of transmitted viruses provides important insights into HIV pathogenesis and informs vaccine development. The aim of the study was to characterize env function of transmitted viruses and its role in disease progression