How explicable are differences between reviews that appear to address a similar research question? A review of reviews of physical activity interventions

Background Systematic reviews are promoted as being important to inform decision-making. However, when presented with a set of reviews in a complex area, how easy is it to understand how and why they may differ from one another? Methods An analysis of eight reviews reporting evidence on effectiveness of community interventions to promote physical activity. We assessed review quality and investigated overlap of included studies, citation of relevant reviews, consistency in reporting, and reasons why specific studies may be excluded. Results There were 28 included studies. The majority (n = 22; 79%) were included only in one review. There was little cross-citation between reviews (n = 4/28 possible citations; 14%). Where studies appeared in multiple reviews, results were consistently reported except for complex studies with multiple publications. Review conclusions were similar. For most reviews (n = 6/8; 75%), we could explain why primary data were not included; this was usually due to the scope of the reviews. Most reviews tended to be narrow in focus, making it difficult to gain an understanding of the field as a whole. Conclusions In areas where evaluating impact is known to be difficult, review findings often relate to uncertainty of data and methodologies, rather than providing substantive findings for policy and practice. Systematic ‘maps’ of research can help identify where existing research is robust enough for multiple in-depth syntheses and also show where new reviews are needed. To ensure quality and fidelity, review authors should systematically search for all publications from complex studies. Other relevant reviews should be searched for and cited to facilitate knowledge-building

Simultaneous fine structure observation of wind and temperature profiles by the Arecibo 430-MHz radar and in situ measurements

A simultaneous campaign of balloon and radar measurements took place on March 14 to 16, 1984, above the Arecibo 430-MHz radar. This radar was operating with a vertical resolution of 150 m following two antenna beam directions: 15 deg. from the zenith, respectively, in the N-S and E-W directions. The main results concerning the comparison between the flight and simultaneous radar measurements obtained on March 15, 1984 are analyzed. The radar return power profile (S/N ratio in dB) exhibits maxima which are generally well correlated with step-like structures in the potential temperature profile. These structures are generally considered as the consequence of the mixing processes induced by the turbulence. A good correlation appears in the altitude range 12.5 to 19 km between wind shears induced by a wave structure observed in the meridional wind and the radar echo power maxima. This wave structure is characterized by a vertical wavelength of about 2.5 km, and a period in the range 30 to 40 hours. These characteristics are deduced from the twice daily rawinsonde data launched from the San Juan Airport by the National Weather Service. These results pointed out an example of the interaction between wave and turbulence in the upper troposphere and lower stratosphere. Turbulent layers are observed at locations where wind shears related to an internal inertia-gravity wave are maxima

The First Passage Probability of Intracellular Particle Trafficking

The first passage probability (FPP), of trafficked intracellular particles reaching a displacement L, in a given time t or inverse velocity S = t/L, can be calculated robustly from measured particle tracks, and gives a measure of particle movement in which different types of motion, e.g. diffusion, ballistic motion, and transient run-rest motion, can readily be distinguished in a single graph, and compared with mathematical models. The FPP is attractive in that it offers a means of reducing the data in the measured tracks, without making assumptions about the mechanism of motion: for example, it does not employ smoothing, segementation or arbitrary thresholds to discriminate between different types of motion in a particle track. Taking experimental data from tracked endocytic vesicles, and calculating the FPP, we see how three molecular treatments affect the trafficking. We show the FPP can quantify complicated movement which is neither completely random nor completely deterministic, making it highly applicable to trafficked particles in cell biology.Comment: Article: 13 pages, 8 figure

Aminopiperidine based complexes for lactide polymerisation

Herein we report the synthesis and characterisation of a series of salalen and salan ligands derived from 2-(aminomethyl)piperidine. Depending on the choice of starting salicylaldehyde, a bicyclic salan type ligand (1-3H2) or imino salalen type ligand (4-6H, 7-9H2) were prepared. The ligands were successfully complexed to group 4 metals and aluminium; with hafnium and zirconium octahedral complexes, M(1-3)2, were realized; whilst with aluminium tetrahedral and trigonal bipyramidal complexes, Al(1-9)Mex (x = 1,2), were isolated. The complexes have been characterised in solution via 1H and 13C{1H} NMR spectroscopy and in the solid state by X-ray crystallography. The group 4 complexes were observed to have a fac-fac arrangement of ligands and there were two isomers present when 3H2 was ligated. The imino aluminium complexes Al(7-9)Me were isolated as a mixture of diastereoisomers. The resultant complexes were trialed in the ring opening polymerisation of rac-lactide with both heterotactic and isotactic PLA being demonstrated. Tacticity was found to be dependent on the nature of the ligand and metal used; the M(1-3)2 complexes were generally found to have a heterotactic preference (Pr = 0.67-0.76) and the aluminium polymerisation outcome was dictated more by the steric influence of the ligand, particularly for Al(4-6)Me2/Al(7-9)M

Interactive Effects of Different Visual Imagery Perspectives and Narcissism on Motor Performance

Two studies examined the interactive effects of different visual imagery perspectives and narcissism on motor performance. In both studies participants completed the Narcissistic Personality Inventory (NPI-40: Raskin & Hall, 1979) and were assigned to either an internal visual imagery or external visual imagery group. Participants then performed a motor task (dart throwing in Study 1 and golf putting in Study 2) under conditions of practice, low self-enhancement, and high self-enhancement. Following completion of the respective tasks, participants were categorized into high and low narcissistic groups based on their NPI-40 scores. In both studies, high narcissists using external visual imagery significantly improved performance from the low to the high self-enhancement condition, whereas high narcissists using internal visual imagery did not. Low narcissists remained relatively constant in performance across self-enhancement conditions, regardless of perspective. The results highlight the importance of considering personality characteristics when examining the effects of visual imagery perspectives on performance

Pediatric anesthesia in Europe:Variations within uniformity

Organization of healthcare strongly differs between European countries and results in country-specific requirements in postgraduate medical training. Within the European Union (EU), the European Board of Anaesthesiology has set recommendations of training for the Specialty of Anaesthesiology including standards for Postgraduate Medical Specialist training including a description for providing service in pediatric anesthesia. However, these standards are advisory and not mandatory. Here we aimed to review the current state and associated challenges of pediatric anesthesia training in Europe. We report an important country-specific variability both in training and regulations of practice of pediatric anesthesia in the EU and in the United Kingdom. The requirements for training in pediatric anesthesia varies between nothing specified (Belgium) or providing anesthesia with direct supervision to a minimum of 50 cases below 5 years of age (Germany) to 3–6 month clinical practice in a specialized pediatric hospital (France). Likewise, the regulations for providing anesthesia to children varies from no regulations at all (Belgium) to age specific requirements and centralization of all children below 4 years of age to specified centers (United Kingdom). Officially recognized pediatric anesthesia fellowship programs are not available in most countries of Europe. It remains unclear if and how country-specific differences in pediatric anesthesia training are associated with clinical outcomes in pediatric perioperative care. There is converging interest and support for the establishment of a European pediatric anesthesia curriculum.</p

Laboratory experiments and grain based discrete element numerical simulations investigating the thermo-mechanical behaviour of sandstone

Thermo-mechanical loading can occur in numerous engineering geological environments, from both natural and anthropogenic sources. Different minerals and micro-defects in rock cause heterogeneity at a grain scale, affecting the mechanical and thermal properties of the material. Changes in strength and stiffness can occur from exposure to elevated temperatures, with the accumulation of localised stresses resulting in thermally induced micro-cracking within the rock. In this study we investigated thermal micro-cracking at a grain scale through both laboratory experiments and their numerical simulations. We performed laboratory triaxial experiments on specimens of fine-grained sandstone at a confining pressure of 5 MPa and room temperature (20∘C), as well as heating to 50∘C, 75∘C and 100∘C prior to mechanical loading. The laboratory experiments were then replicated using discrete element method simulations. The geometry and granular structure of the sandstone was replicated using a Voronoi tessellation scheme to produce a grain based model. Strength and stiffness properties of the Voronoi contacts were calibrated to the laboratory specimens. Grain scale thermal properties were applied to the grain based models according to mineral percentages obtained from quantitative X-ray diffraction analysis on laboratory specimens. Thermo-mechanically coupled modelling was then undertaken to reproduce the thermal loading rates used in the laboratory, before applying a mechanical load in the models until failure. Laboratory results show a reduction of up to 15% peak strength with increasing thermal loading between room temperature and 100∘C , and micro-structural analysis shows the development of thermally induced micro-cracking in laboratory specimens. The mechanical numerical simulations calibrate well with the laboratory results, and introducing coupled thermal loading to the simulations shows the development of localised stresses within the models, leading to the formation of thermally induced micro-cracks and strength reduction upon mechanical loading

Aminopiperidine based complexes for lactide polymerisation

A series of new ligands based on a 2-(aminomethyl)piperidine motif have been prepared. An interesting diversity in structure is observed, all complexes have been trialled for the polymerisation of rac-lactide.</p

The selection of search sources influences the findings of a systematic review of people’s views: a case study in public health

Background For systematic reviews providing evidence for policy decisions in specific geographical regions, there is a need to minimise regional bias when seeking out relevant research studies. Studies on people’s views tend to be dispersed across a range of bibliographic databases and other search sources. It is recognised that a comprehensive literature search can provide unique evidence not found from a focused search; however, the geographical focus of databases as a potential source of bias on the findings of a research review is less clear. This case study describes search source selection for research about people’s views and how supplementary searches designed to redress geographical bias influenced the findings of a systematic review. Our research questions are: a) what was the impact of search methods employed to redress potential database selection bias on the overall findings of the review? and b) how did each search source contribute to the identification of all the research studies included in the review? Methods The contribution of 25 search sources in locating 28 studies included within a systematic review on UK children’s views of body size, shape and weight was analysed retrospectively. The impact of utilising seven search sources chosen to identify UK-based literature on the review’s findings was assessed. Results Over a sixth (5 out of 28) of the studies were located only through supplementary searches of three sources. These five studies were of a disproportionally high quality compared with the other studies in the review. The retrieval of these studies added direction, detail and strength to the overall findings of the review. All studies in the review were located within 21 search sources. Precision for 21 sources ranged from 0.21% to 1.64%. Conclusions For reducing geographical bias and increasing the coverage and context-specificity of systematic reviews of people’s perspectives and experiences, searching that is sensitive and aimed at reducing geographical bias in database sources is recommended