A Method for Modeling Low-Probability, High- Consequence Risk Events: Vessel Traffic on the Lower Mississippi River

[Excerpt] A variety of commodities, from chlorine to corn and petroleum to passengers, are transported on the lower Mississippi River regularly. Corn, wheat and coal are the most commonly carried commodities. From a human health and safety perspective, these are relatively benign products in that a vessel accident and spill of these are not directly hazardous to people, whatever other ecological disturbances may ensue. However, over eighty million tons of petroleum products are transported on the river annually. Over a million tons of liquid natural gas traverse the river through the center of New Orleans. Additionally, over 400,000 tons of ammonium nitrate2 pass through the center of Baton Rouge annually. The potential for a technological disaster is certainly present […] The vast majority of the literature relevant to the question of vessel accident risk concerns the question of on-board causes of vessel accidents. It is assumed that the predictors of which vessel will have an accident are on-board the vessel (i.e., vessel and crew characteristics). The most commonly cited on-board hazards include: the size of the vessel; the age of the vessel; the length of the vessel; whether the vessel is single or double hulled; the maintenance of the vessel; the classification society under which the vessel is registered; the type of ownership; the history of ownership; where the vessel is flagged (i.e., flag of convenience or traditional maritime nation); license qualifications of mates and engineers; the vessel’s casualty history; the vessel’s history of violations; whether the vessel has system (e.g., steering) redundancy; and personnel history (including manning levels and the comparison of the present levels of manning with that of the vessel in the past and with similar type vessels)

Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD

Duchenne muscular dystrophy (DMD) is a genetic disease affecting about one in every 3,500 boys. This X-linked pathology is due to the absence of dystrophin in muscle fibers. This lack of dystrophin leads to the progressive muscle degeneration that is often responsible for the death of the DMD patients during the third decade of their life. There are currently no curative treatments for this disease but different therapeutic approaches are being studied. Gene therapy consists of introducing a transgene coding for full-length or a truncated version of dystrophin complementary DNA (cDNA) in muscles, whereas pharmaceutical therapy includes the use of chemical/biochemical substances to restore dystrophin expression or alleviate the DMD phenotype. Over the past years, many potential drugs were explored. This led to several clinical trials for gentamicin and ataluren (PTC124) allowing stop codon read-through. An alternative approach is to induce the expression of an internally deleted, partially functional dystrophin protein through exon skipping. The vectors and the methods used in gene therapy have been continually improving in order to obtain greater encapsidation capacity and better transduction efficiency. The most promising experimental approaches using pharmaceutical and gene therapies are reviewed in this article

Hazards to Navigation on the Lower Mississippi River and at -Risk Human Populations.

This dissertation tests whether known hazards to navigation determine the location of vessel accidents along the lower Mississippi River and describes the human populations most at risk according to predictions. The data are comprised of the relative risk index of river hazards (Forsyth et al. 1996, Gramling et al. 1998), the demographic characteristics of nearby residents, (U.S. Census 1990), and actual U.S. Coast Guard accident reports. Usable predictors of vessel accidents and a knowledge of population characteristics will enable better planning of emergency response, better placement of emergency response equipment, and more effective efforts to prevent vessel. accidents along the lower Mississippi River which is the busiest commercial waterway in the world. In the models computed here, vessel accidents are generally well predicted by the location of known hazards. Results of these models indicate that the human populations at-risk vary widely along the river. At some accident prone points, population density is very high, and many persons are at risk. At other hazardous locations, population density is quite low. Socioeconomic characteristics of the at-risk populations vary from one dangerous location to another. Some at-risk populations are relatively affluent and others are impoverished. The racial and ethnic composition also varies such that some hazardous locations are inhabited primarily by racial and ethnic minorities, while others are settled by majority racial and ethnic groups. This population heterogeneity should be taken into account in planning, preparation and response to river vessel accidents

A Preliminary Review of Undergraduate Student Interest and Perceptions about Taking Online, Web-based Sociology Courses

Abstract This preliminary assessment sought to examine 1) student perception about the benefits and drawbacks of online, web-based courses in general, and 2) interest in web-based Sociology courses in particular. Online, web-based instruction is a part of mainstream education and currently universities nation-wide are beginning to turn towards online, web-based instruction as a way to reach more students. Yet, there is limited research about student perception in general and about web-based Sociology courses in particular. The results of this study indicate that student interest is highly motivated by attendance -not needing to attend a physical class, and students perceive not having regular contact with the instructor as the most relevant drawback. Results also show that overall students are interested in taking sociology online, web-based courses

Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD

Duchenne muscular dystrophy (DMD) is a genetic disease affecting about one in every 3,500 boys. This X-linked pathology is due to the absence of dystrophin in muscle fibers. This lack of dystrophin leads to the progressive muscle degeneration that is often responsible for the death of the DMD patients during the third decade of their life. There are currently no curative treatments for this disease but different therapeutic approaches are being studied. Gene therapy consists of introducing a transgene coding for full-length or a truncated version of dystrophin complementary DNA (cDNA) in muscles, whereas pharmaceutical therapy includes the use of chemical/biochemical substances to restore dystrophin expression or alleviate the DMD phenotype. Over the past years, many potential drugs were explored. This led to several clinical trials for gentamicin and ataluren (PTC124) allowing stop codon read-through. An alternative approach is to induce the expression of an internally deleted, partially functional dystrophin protein through exon skipping. The vectors and the methods used in gene therapy have been continually improving in order to obtain greater encapsidation capacity and better transduction efficiency. The most promising experimental approaches using pharmaceutical and gene therapies are reviewed in this article