139 research outputs found
Clinical Evaluation of Rapid Diagnostic Test Kit Using the Polysaccharide as a Genus-Specific Diagnostic Antigen for Leptospirosis in Korea, Bulgaria, and Argentina
- Author
- Publication venue
- 'Korean Academy of Medical Sciences'
- Publication date
- 26/01/2016
- Field of study
Leptospirosis, a zoonotic disease that is caused by many serovars which are more than 200 in the world, is an emerging worldwide disease. Accurate and rapid diagnostic tests for leptospirosis are a critical step to diagnose the disease. There are some commercial kits available for diagnosis of leptospirosis, but the obscurity of a species- or genus-specific antigen of pathogenic Leptospira interrogans causes the reduced sensitivity and specificity. In this study, the polysaccharide derived from lipopolysaccharide (LPS) of nonpathogenic Leptospira biflexa serovar patoc was prepared, and the antigenicity was confirmed by immunoblot and enzyme linked immunosorbent assay (ELISA). The performance of the rapid diagnostic test (RDT) kit using the polysaccharide as a diagnostic antigen was evaluated in Korea, Bulgaria and Argentina. The sensitivity was 93.9%, 100%, and 81.0% and the specificity was 97.9%, 100%, and 95.4% in Korea (which is a rare region occurring with 2 serovars mostly), Bulgaria (epidemic region with 3 serovars chiefly) and Argentina (endemic region with 19 serovars mainly) respectively. These results indicate that this RDT is applicable for global diagnosis of leptospirosis. This rapid and effective diagnosis will be helpful for diagnosis and manage of leptospirosis to use and the polysaccharide of Leptospira may be called as genus specific antigen for diagnosis
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
- Gejman Pablo V.
- Geus Eco J C
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gjesing Anette P.
- Glass Daniel
- Glazer Nicole L.
- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Åsa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Kerr-Conte Julie
- Ketkar Shamika
- Kettunen Johannes
- Khaw Kay Tee
- Kiemeney Lambertus A.
- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
- Lango Allen Hana
- Lantieri Olivier
- Lanzani Chiara
- Launer Lenore J.
- Lauritzen Torsten
- Lawlor Debbie A.
- Lawrence Robert W.
- Leander Karin
- Lecoeur Cecile
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
- Lian Liming
- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
- Loos Ruth J F
- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
- Merlini Pier Angelica
- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
- Nilesh J Samani
- Nilsson Peter
- Nisbet James
- North Kari E.
- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
- Osmond Clive
- Ostenson Claes-Göran
- Ouwehand Willem H.
- Owen Katharine R.
- Palmer Colin N A
- Palmer Lyle J.
- Pankow James S.
- Par Ju Hyun
- Parish Sarah
- Park Ju-Hyun
- Parker Alex N.
- Parts Leopold
- Paré Guillaume
- Pascoe Laura
- Patel Riyaz S.
- Patterson Chris C.
- Pattou François
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Pellikka Niina
- Peltonen Leena
- Penninx Brenda W.
- Perola Markus
- Perry John R B
- Peter M Visscher
- Peters Annette
- Peters Marjolein J.
- Petersen Ann Kristin
- Peto Richard
- Petrie John R.
- Peyvandi Flora
- Pichler Irene
- Pietiläinen Kirsi H.
- Platou Carl
- Platou Carl G P
- Polasek Ozren
- Potter Simon
- Pouta Anneli
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Purcell Shaun
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rafelt Suzanne
- Raitakari Olli
- Rallidis Loukianos S.
- Randal Joshua C.
- Randall Joshua C
- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
- Rayner Nigel W.
- Reilly Muredach P.
- Reinehr Thomas
- Rice Catherine
- Ridderstråel Martin
- Ridderstråle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
- Sayer Avan A.
- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
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- Schäfer Arne
- Scott James
- Scott Laura J.
- Seedorf Udo
- Segrè Ayellet V.
- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
- Uitterlinden André
- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
- Author
- A'Court C.
- Aaroe H.
- Abd El-Aziz A.
- Abdalla Saad J.
- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
- Abe M. (Masahiko)
- Abe M. (Masatake)
- Abe M. (Mitsunori)
- Abe S.
- Abe Y.
- Abhayaratna W.
- Abou Seif S. K.
- Abraham S.
- Abu-Mahfouz M.
- Abushal S.
- Accetta Gabriele
- Accogli M.
- Adachi S.
- Adachi S. (Sen)
- Adachi S. (Susumu)
- Adachi T.
- Adak D.
- Adriaansen H.
- Agakhanyan A.
- Agata J.
- Ageta M.
- Aggarwala A.
- Agliardi P.
- Agnelli G.
- Agnelli Giancarlo
- Agrawal A.
- Aguilar J.
- Ahbeck E.
- Ahlmark H.
- Ahmad K.
- Ahmad N.
- Ahmad S.
- Ahmed F.
- Ahmed W.
- Ahn J. J.
- Ahuad Guerrero R. A.
- Ainsworth P.
- Airaksinen J.
- Akahane K.
- Akiyama M.
- Aktas O.
- Akutsu M.
- Al Mahmeed W.
- Al Mahmeed Wael
- Al Mulla A.
- Al Naeemi A.
- Al Omairi M.
- Al-Khalili F.
- Alaguibe E. D.
- Alban F.
- Alberts M.
- Alborough E.
- Aldegather J.
- Aleksandrova E.
- Alfaro T. A. A.
- Alfieri A.
- Ali A.
- Alkan D. Uzun
- Allasia B.
- Almeida Fernandez C. A.
- Alonso C. (Carmela)
- Alonso C. (Concepcion)
- Alpay D.
- Altamirano Bellorin S.
- Altun A.
- Alunni M.
- Alvarez D'Amelio A.
- Alvarez Garcia P.
- Alvarez Lopez H.
- Alvarez D.
- Alvarez M.
- Alves da Costa F. A.
- Alves de Oliveira Gomes J.
- Alzand B.
- Amano T.
- Amarenco P.
- Amaro M.
- Ambicka M.
- Ambrosino P.
- Ambrosio Giuseppe
- Amstutz D.
- An H. J.
- Andere N.
- Andersson A.
- Andersson L. (Lars)
- Andersson L. (Lisbeth)
- Ando H.
- Ando S.
- Andrzejewski D.
- Angaran P.
- Angchaisuksiri P.
- Angchaisuksiri Pantep
- Angel G.
- Ann W.
- Antonova P.
- Antonsen H.
- Aoki K.
- Aoyama T.
- Arabetti C.
- Aracil Villar J.
- Arai H.
- Araminowicz J.
- Aranha Rosito G. B.
- Aras D.
- Aras F.
- Arasaki O.
- Araujo G. R.
- Araujo V
- Arcocha Torres M. F.
- Argena A.
- Arias L.
- Arima S.
- Arino T.
- Armaganijan D.
- Armitano Ochoa R.
- Aro L.
- Arola O.
- Arriaga Nava R.
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- Arruda Nakazone M.
- Arstall M.
- Asafu-Adjaye N.
- Asano H.
- Asano T.
- Ascoop A-K
- Ashida K.
- Assouline S.
- Astridge P.
- Astudillo C.
- Atar D.
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- Ausen K.
- Austria A.
- Avanzino G.
- Avena R.
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- Axthelm C.
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- Aydinlar A.
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- Baba T.
- Babjakova Z.
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Pan-cancer analysis of whole genomes
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- Sieverling
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- Simons J. V. w
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
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- Thomas
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- Thompson
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- Thorne
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- Tirabosco
- tj Sweep
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- Urban L. f
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- us Trümper
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- V. ag
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- van Deurzen
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- Van Loo
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- Vazquez
- vb Simon
- vd Biswas
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- Vicentini
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- vo Taniguchi
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- vq Yamamoto
- vx Ong
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- W. bk
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- W. mn
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- Waddell
- Waddell
- Wadi L. k
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- wi Futreal
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- Wong
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- Wright
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- ws Ang
- Wu
- Wu
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- wv abg
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- x Eils
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- xb Danilova
- xb Felau
- xc Lovat
- xh Curley
- xh Fulton
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- Xia
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- xo Abeshouse
- xp Benz
- xp Edwards
- xr Ghori
- xs Gundem
- Xue
- xv Luxton
- xw McDermott
- xy Visakorpi
- xz Whitaker
- Y. -E. ot
- Y. -J. k
- Y. -J. xn
- Y. abp
- Y. ae
- Y. ae
- Y. ae
- Y. ae
- Y. ai
- Y. aj
- Y. al
- Y. bk
- Y. dg
- Y. dy
- Y. ef
- Y. ep
- Y. ez
- Y. ff
- Y. fr
- Y. fv
- Y. fv
- Y. gl
- Y. hl
- Y. hq
- Y. hq
- Y. ia
- Y. kq
- Y. lw
- Y. nh
- Y. nk
- Y. nz
- Y. rg
- Y. rj
- Y. rm
- Y. S. jf
- Y. uz
- Y. vr
- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yaspo
- Yates
- Yau
- yb Ally
- yd Cherniack
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- ye Auman
- ye Umbricht
- Yellapantula
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- yh Bathe
- yj Baylin
- Yoon
- Yu
- Yu
- Yu
- Yuan
- Yugawa
- z ah
- Z. ej
- Z. ep
- Z. fr
- Z. hv
- Z. hy
- Z. jq
- Z. kt
- Z. oe
- Zaikova
- Zapatka
- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
- Author
- Ababneh Hazim S
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd Al Magied Abdallah H A
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelkader Atef
- Abdelmasseh Michael
- Abdi Parsa
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abebe Mesfin
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas Guimarães
- Absalan Abdorrahim
- Abualruz Hasan
- Abubakar Bilyaminu
- Abukhadijah Hana Jihad Jihad
- Addolorato Giovanni
- Adekanmbi Victor
- Adetunji Charles Oluwaseun
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adha Rishan
- Adhikary Ripon Kumar
- Adnani Qorinah Estiningtyas Sakilah
- Adzigbli Leticia Akua
- Afrashteh Fatemeh
- Afzal Muhammad Sohail
- Afzal Saira
- Agbozo Faith
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahlstrom Austin J
- Ahmad Aqeel
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Sajjad
- Ahmad Shahzaib
- Ahmed Anisuddin
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Safoora
- Ahmed Syed Anees
- Akinosoglou Karolina
- Akkaif Mohammed Ahmed
- Akrami Ashley E
- Akter Ema
- Al Awaidy Salah
- Al Hasan Syed Mahfuz
- Al Mosa Amjad S
- Al Ta'ani Omar
- Al Zaabi Omar Ali Mohammed
- Al-Ajlouni Yazan
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Ibraheem Akram
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tammemi Ala'a B.
- Al-Tawfiq Jaffar A
- Al-Wardat Mohammad Sami
- Al-Worafi Yaser Mohammed
- Al-Zyoud Walid
- Alahdab Fares
- Alajlani Muaaz M
- Alalalmeh Samer O
- Alam Khurshid
- Alam Noore
- Alam Tahiya
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albakri Almaza
- Aldhaleei Wafa A
- Aldridge Robert W
- Alemohammad Seyedeh Yasaman
- Alemu Yihun Mulugeta
- Ali Abid
- Ali Amjad
- Ali Iman
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Victor Ekoche
- Ali Waad
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aljunid Syed Mohamed
- Alla François
- Almazan Joseph Uy
- Alqutaibi Ahmed Yaseen
- Alrawashdeh Ahmad
- Alrousan Sahel Majed
- Alsabri Mohammed A
- Altaany Zaid
- Altirkawi Khalid A
- Aluh Deborah Oyine
- Alvis-Guzman Nelson
- Aly Hany
- Alyahya Mohammad Sharif
- Alzoubi Karem H
- Amani Reza
- Ameyaw Edward Kwabena
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amugsi Dickson A
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Andrews Erick Adrian
- Anil Abhishek
- Anil Sneha
- Anoushiravani Amir
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Boluwatife Stephen
- Anvari Saeid
- Anyasodor Anayochukwu Edward
- Appiah Francis
- Aquilano Michele
- Arab Juan Pablo
- Arabloo Jalal
- Arafa Elshaimaa A
- Arafat Mosab
- Aravkin Aleksandr Y
- Ardekani Ali
- Areda Demelash
- Aregawi Brhane Berhe
- Aremu Abdulfatai
- Ariffin Hany
- Arkew Mesay
- Armani Keivan
- Artamonov Anton A
- Arumugam Ashokan
- Asghari-Jafarabadi Mohammad
- Ashbaugh Charlie
- Astell-Burt Thomas
- Athari Seyyed Shamsadin
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Aujayeb Avinash
- Ausloos Marcel
- Awad Hamzeh
- Awotidebe Adedapo Wasiu
- Ayatollahi Haleh
- Ayuso-Mateos Jose L
- Azadnajafabad Sina
- Azeez Fahad Khan
- Azevedo Rui M S
- Badar Muhammad
- Baghdadi Soroush
- Bagheri Mahboube
- Bagheri Nasser
- Bai Ruhai
- Baker Jennifer L
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Balcha Wondu Feyisa
- Baltatu Ovidiu Constantin
- Barchitta Martina
- Bardideh Erfan
- Barker-Collo Suzanne Lyn
- Barqawi Hiba Jawdat
- Barteit Sandra
- Basiru Afisu
- Basso João Diogo
- Bastan Mohammad-Mahdi
- Basu Sanjay
- Bauckneht Matteo
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- Bärnighausen Till Winfried
- Behnoush Amir Hossein
- Behzadi Payam
- Beiranvand Maryam
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bemanalizadeh Maryam
- Bensenor Isabela M
- Benzian Habib
- Beran Azizullah
- Berezvai Zombor
- Bernstein Robert S
- Bettencourt Paulo J G
- Beyene Kebede A
- Beyene Melak Gedamu
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhandari Dinesh
- Bharadwaj Ravi
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhattacharjee Natalia V
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhuiyan Mohiuddin Ahmed
- Bisignano Catherine
- Biswas Bijit
- Bjørge Tone
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bonakdar Hashemi Milad
- Bora Basara Berrak
- Borhany Hamed
- Bosoka Samuel Adolf
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boufous Soufiane
- Boxe Christopher
- Boyko Edward J
- Brady Oliver J
- Braithwaite Dejana
- Brauer Michael
- Brazo-Sayavera Javier
- Brenner Hermann
- Brown Colin Stewart
- Browne Annie J
- Brugha Traolach
- Bryazka Dana
- Bulamu Norma B
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Busse Reinhard
- Bustanji Yasser
- Butt Zahid A
- Caetano dos Santos Florentino Luciano
- Calina Daniela
- Campos Luciana Aparecida
- Cao Shujin
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- Carreras Giulia
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- Castaldelli-Maia Joao Mauricio
- Castelpietra Giulio
- Cattaruzza Maria Sofia
- Caye Arthur
- Cárdenas Rosario
- Cegolon Luca
- Cembranel Francieli
- Cenko Edina
- Cerin Ester
- Chadban Steven J
- Chadwick Joshua
- Chakraborty Chiranjib
- Chakraborty Sandip
- Chalek Julian
- Chan Jeffrey Shi Kai
- Chandika Rama Mohan
- Chandy Sara
- Charan Jaykaran
- Chaudhary Anis Ahmad
- Chaurasia Akhilanand
- Chen An-Tian
- Chen Haowei
- Chen Meng Xuan
- Chen Simiao
- Cherbuin Nicolas
- Chi Gerald
- Chichagi Fatemeh
- Chimed-Ochir Odgerel
- Chimoriya Ritesh
- Ching Patrick R
- Chirinos-Caceres Jesus Lorenzo
- Chitheer Abdulaal
- Cho Daniel Youngwhan
- Cho William C S
- Choi Dong-Woo
- Chong Bryan
- Chong Chean Lin
- Chopra Hitesh
- Chu Dinh-Toi
- Chung Eric
- Chutiyami Muhammad
- Clayton Justin T
- Cogen Rebecca M
- Cohen Aaron J
- Columbus Alyssa
- Comfort Haley
- Conde Joao
- Connolly Jon T
- Cooper Ezra E K
- Cortese Samuele
- Cruz-Martins Natália
- Çakmak Barsbay Mehtap
- D'Oria Mario
- da Silva Alanna Gomes
- Dadras Omid
- Dai Xiaochen
- Dai Zhaoli
- Dalton Bronte E
- Damiani Giovanni
- Dandona Lalit
- Dandona Rakhi
- Das Jai K
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- Davletov Kairat
- De la Hoz Fernando Pio
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- Desai Hardik Dineshbhai
- Devanbu Vinoth Gnana Chellaiyan
- Dewan Syed Masudur Rahman
- Dhama Kuldeep
- Dhane Amol S
- Dhingra Sameer
- Dias da Silva Diana
- Diaz Daniel
- Diaz Luis Antonio
- Diaz Michael J
- Dima Adriana
- Ding Delaney D
- do Prado Camila Bruneli
- Do Thao Huynh Phuong
- Dodangeh Masoud
- Dodangeh Milad
- Doegah Phidelia Theresa
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- Dong Wanyue
- Doshi Rajkumar
- Dowou Robert Kokou
- Dsouza Haneil Larson
- Dsouza Viola
- Dube John
- Dumith Samuel C
- Duncan Bruce B
- Duraes Andre Rodrigues
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
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- Dziedzic Arkadiusz Marian
- Eboreime Ejemai
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- Efendi Ferry
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- Eini Ebrahim
- Ekundayo Temitope Cyrus
- El Arab Rabie Adel
- El Sayed Iman
- Elamin Osman
- Elemam Noha Mousaad
- ElGohary Ghada Metwally Tawfik
- Elhadi Muhammed
- Elmeligy Omar Abdelsadek Abdou
- Elmoselhi Adel B
- Elshaer Mohammed
- Elsohaby Ibrahim
- Eltahir Mohd. Elmagzoub
- Emeto Theophilus I
- Eshrati Babak
- Eslami Majid
- Esmaeili Zahra
- Fabin Natalia
- Fagbamigbe Adeniyi Francis
- Fagbule Omotayo Francis
- Falzone Luca
- Fareed Mohammad
- Farinha Carla Sofia e Sá
- Faris MoezAlIslam Ezzat Mahmoud
- Faro Andre
- Fasihi Kiana
- Fatehizadeh Ali
- Fauk Nelsensius Klau
- Fazylov Timur
- Feigin Valery L
- Fekadu Ginenus
- Feng Xiaoqi
- Fereshtehnejad Seyed-Mohammad
- Ferrara Pietro
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- Firew Belete Sewasew
- Fischer Florian
- Fitriana Ida
- Flavel Joanne
- Flor Luisa S
- Folayan Morenike Oluwatoyin
- Foley Kristen Marie
- Fonzo Marco
- Force Lisa M
- Foschi Matteo
- Freitas Alberto
- Fridayani Ni Kadek Yuni
- Fukutaki Kai Glenn
- Furtado João M
- Fux Blima
- Gaal Peter Andras
- Gadanya Muktar A
- Gallus Silvano
- Ganesan Balasankar
- Ganiyani Mohammad Arfat
- Gautam Rupesh K
- Gebi Tilaye Gebru
- Gebregergis Miglas W
- Gebrehiwot Mesfin
- Getacher Lemma
- Getahun Genanew K A
- Gething Peter W
- Ghadimi Delaram J
- Ghadirian Fataneh
- Ghafarian Sadegh
- Ghailan Khalid Yaser
- Ghasemi MohammadReza
- Ghasempour Dabaghi Ghazal
- Ghazy Ramy Mohamed
- Ghoba Sama
- Gholami Ehsan
- Gholamrezanezhad Ali
- Gholizadeh Nasim
- Ghorbani Vajargah Pooyan
- Ghorbani Mahsa
- Ghotbi Elena
- Gil Artyom Urievich
- Gill Tiffany K
- Girmay Alem
- Glasbey James C
- Glushkova Ekaterina Vladimirovna
- Gnedovskaya Elena V
- Goldust Mohamad
- Goleij Pouya
- Golinelli Davide
- Gopalani Sameer Vali
- Goulart Alessandra C
- Gouravani Mahdi
- Goyal Anmol
- Göbölös Laszlo
- Grivna Michal
- Grosso Giuseppe
- Guarducci Giovanni
- Gubari Mohammed Ibrahim Mohialdeen
- Guicciardi Stefano
- Guimarães Rafael Alves
- Gulati Snigdha
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- Gupta Rahul
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- Gupta Vijai Kumar
- Haakenstad Annie
- Hadi Najah R
- Haep Nils
- Hafiz Abdul
- Haghmorad Dariush
- Haile Demewoz
- Haj-Mirzaian Arvin
- Hajj Ali Adel
- Hajj Ali Ali
- Halboub Esam S
- Haller Sebastian
- Halwani Rabih
- Hamagharib Abdullah Kanaan
- Hamdy Nadia M
- Hamoudi Rifat
- Hanifi Nasrin
- Hankey Graeme J
- Haq Zaim Anan
- Haque Md Rabiul
- Harapan Harapan
- Hargono Arief
- Haro Josep Maria
- Hasaballah Ahmed I
- Hasan S. M. Mahmudul
- Hasanian Mohammad
- Hasnain Md Saquib
- Hassan Amr
- Haubold Johannes
- Hay Simon I
- Hebert Jeffrey J
- Hegazi Omar E
- Heidari Mohammad
- Hemmati Mehdi
- Henson Claire A
- Herrera-Serna Brenda Yuliana
- Herteliu Claudiu
- Heydari Majid
- Hezam Kamal
- Hidayana Irma
- Hiraike Yuta
- Hoan Nguyen Quoc
- Holla Ramesh
- Hoogar Praveen
- Horita Nobuyuki
- Hossain Md Mahbub
- Hosseinzadeh Hassan
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Hu Chengxi
- Huang Junjie
- Hultström Michael
- Hundie Tsegaye Gebreyes
- Hunt Aliza J
- Hushmandi Kiavash
- Hussain Javid
- Hussain M. Azhar
- Hussein Nawfal R
- Huynh Hong-Han
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Iftikhar Pulwasha Maria
- Ikiroma Adalia I
- Ikwegbue Paul Chukwudi
- Ilic Irena M
- Ilic Milena D
- Immurana Mustapha
- Isa Mustafa Alhaji
- Islam Md. Rabiul
- Islam Sheikh Mohammed Shariful
- Ismail Faisal
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- Iyamu Ihoghosa Osamuyi
- Jacob Louis
- Jacobsen Kathryn H
- Jafarinia Morteza
- Jahankhani Kasra
- Jahanmehr Nader
- Jain Nityanand
- Jairoun Ammar Abdulrahman
- Jakhmola Mani Dr Ruchi
- Jamil Safayet
- Jamora Roland Dominic G
- Jatau Abubakar Ibrahim
- Javadov Sabzali
- Javaheri Tahereh
- Jayaram Shubha
- Jee Sun Ha
- Jeganathan Jayakumar
- Jiang Heng
- Jokar Mohammad
- Jonas Jost B
- Joseph Nitin
- Joshua Charity Ehimwenma
- Jürisson Mikk
- K Vaishali
- Kabir Ali
- Kabir Zubair
- Kadashetti Vidya
- Kalankesh Laleh R
- Kalra Sanjay
- Kamath Ashwin
- Kamath Rajesh
- Kamireddy Arun
- Kanaan Mona
- Kanchan Tanuj
- Kanmiki Edmund Wedam
- Kanmodi Kehinde Kazeem
- Kansal Sushil Kumar
- Karim Asima
- Karkhah Samad
- Kashoo Faizan Zaffar
- Kasraei Hengameh
- Kassel Molly B
- Katikireddi Srinivasa Vittal
- Kauppila Joonas H
- Kaur Harkiran
- Kayode Gbenga A
- Kazemi Foad
- Kazemian Sina
- Kebede Fassikaw
- Kendal Evie Shoshannah
- Kesse-Guyot Emmanuelle
- Khademvatan Shahram
- Khajuria Himanshu
- Khalaji Amirmohammad
- Khalid Asaad
- Khalid Nauman
- Khalilian Alireza
- Khamesipour Faham
- Khan Fayaz
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- Khan Moien AB
- Khanmohammadi Shaghayegh
- Khatab Khaled
- Khatatbeh Haitham
- Khatatbeh Moawiah Mohammad
- Khatib Mahalaqua Nazli
- Khayat Kashani Hamid Reza
- Kheirallah Khalid A
- Khokhar Manoj
- Khormali Moein
- Khorrami Zahra
- Khosla Atulya Aman
- Khosravi Majid
- Khosrowjerdi Mahmood
- Khubchandani Jagdish
- Kifle Zemene Demelash
- Kim Grace
- Kim Julie Sojin
- Kim Min Seo
- Kim Yun Jin
- Kimokoti Ruth W
- Kisa Adnan
- Kisa Sezer
- Knibbs Luke D
- Knudsen Ann Kristin Skrindo
- Kochhar Sonali
- Kolahi Ali-Asghar
- Kompani Farzad
- Koren Gerbrand
- Korzh Oleksii
- Krishan Kewal
- Krishna Varun
- Krishnamoorthy Vijay
- Kucuk Bicer Burcu
- Kuddus Md Abdul
- Kuddus Mohammed
- Kuitunen Ilari
- Kujan Omar
- Kulimbet Mukhtar
- Kulkarni Vishnutheertha
- Kumar G Anil
- Kumar Harish
- Kumar Nithin
- Kumar Rakesh
- Kumar Vijay
- Kundu Amartya
- Kusuma Dian
- Kyei-Arthur Frank
- Kytö Ville
- Kyu Hmwe Hmwe
- La Vecchia Carlo
- Lacey Ben
- Ladan Muhammad Awwal
- Laflamme Lucie
- Lahariya Chandrakant
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- Lan Qing
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- Landires Iván
- Lanfranchi Francesco
- Langguth Berthold
- Lansingh Van Charles
- Laplante-Lévesque Ariane
- Larijani Bagher
- Larsson Anders O
- Lasrado Savita
- Lauriola Paolo
- Lawlor Hilary R
- Lám Judit
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- Le Trang Diep Thanh
- Leasher Janet L
- Lee Doo Woong
- Lee Munjae
- Lee Paul H
- Lee Sang-woong
- Lee Seung Won
- Lee Shaun Wen Huey
- Lee Yo Han
- Leigh James
- Leong Elvynna
- Li Ming-Chieh
- Libra Massimo
- Ligade Virendra S
- Lim Lee-Ling
- Lim Stephen S
- Limenh Liknaw Workie
- Lindholm Daniel
- Lindstedt Paulina A
- Listl Stefan
- Liu Gang
- Liu Shiwei
- Liu Shuke
- Liu Xiaofeng
- Liu Xuefeng
- Llanaj Erand
- Loreche Arianna Maever
- Lotufo Paulo A
- Lozano Rafael
- López-Bueno Rubén
- López-Gil José Francisco
- Lubinda Jailos
- Lucchetti Giancarlo
- Luo Lisha
- Lusk Jay B
- Lv Lei
- M Amin Hawraz Ibrahim
- Ma Zheng Feei
- Maass Kelsey Lynn
- Machairas Nikolaos
- Machoy Monika
- Madureira-Carvalho Áurea M
- Magdy Abd El Razek Hassan
- Maghazachi Azzam A
- Mahadeshwara Prasad D. R.
- Mahalleh Mehrdad
- Mahasha Phetole Walter
- Mahmoud Mansour Adam
- Mahmoudi Elham
- Mahmoudvand Golnaz
- Makama Maureen
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- Malta Deborah Carvalho
- Manla Yosef
- Mansour Ali
- Mansouri Mohammad Hadi
- Mansouri Pejman
- Mansouri Vahid
- Mansourian Marjan
- Mansournia Mohammad Ali
- Marasini Bishnu P
- Marateb Hamid Reza
- Maravilla Joemer C
- Mardi Parham
- Marjani Abdoljalal
- Markazi Moghadam Hamed
- Marrugo Arnedo Carlos Alberto
- Martinez Gabriel
- Martinez-Piedra Ramon
- Martins-Melo Francisco Rogerlândio
- Martorell Miquel
- Marx Wolfgang
- Marzo Roy Rillera
- Masoudi Sahar
- Mathangasinghe Yasith
- Mathioudakis Alexander G
- Mathur Medha
- Mathur Navgeet
- Mathur Neeta
- Matozinhos Fernanda Penido
- Mattumpuram Jishanth
- Maude Richard James
- Maugeri Andrea
- Mayeli Mahsa
- Mazidi Mohsen
- Mazzotti Antonio
- McGrath John J
- McKee Martin
- McKowen Anna Laura W
- McPhail Michael A
- McPhail Steven M
- Mehmood Asim
- Mehrabani-Zeinabad Kamran
- Mehravar Sepideh
- Mekene Meto Tesfahun
- Melese Endalkachew Belayneh
- Mendez-Lopez Max Alberto Mendez
- Mendoza Walter
- Menezes Ritesh G
- Mensah George A
- Mensah Laverne G
- Mentis Alexios-Fotios A
- Meo Sultan Ayoub
- Meretoja Atte
- Meretoja Tuomo J
- Mersha Abera M
- Mestrovic Tomislav
- Mettananda Kukulege Chamila Dinushi
- Mettananda Sachith
- Mhlanga Adquate
- Mhlanga Laurette
- Miazgowski Tomasz
- Michalek Irmina Maria
- Micheletti Gomide Nogueira de Sá Ana Carolina
- Miller Ted R
- Minh Le Huu Nhat
- Mirahmadi Alireza
- Mirijello Antonio
- Mirrakhimov Erkin M
- Mirzaei Roya
- Mitchell Philip B
- Mittal Chaitanya
- Moberg Madeline E
- Moghadam Fard Atousa
- Mohajelin Seyedehfatemeh
- Mohamadkhani Ashraf
- Mohamed Ahmed Ismail
- Mohamed Jama
- Mohamed Mouhand F H
- Mohamed Nouh Saad
- Mohammad Ameen Mosa
- Mohammadi Soheil
- Mohammed Hussen
- Mohammed Mustapha
- Mohammed Shafiu
- Mokdad Ali H
- Molokhia Mariam
- Momani Shaher Mohammad
- Momtazmanesh Sara
- Monasta Lorenzo
- Mondello Stefania
- Moni Mohammad Ali
- Montazeri Fateme
- Moodi Ghalibaf AmirAli
- Moradi Maryam
- Moradi Yousef
- Moraga Paula
- Morawska Lidia
- Moreira Rafael Silveira
- Morovatdar Negar
- Morrison Shane Douglas
- Mosapour Abbas
- Mosser Jonathan F
- Mossialos Elias
- Motappa Rohith
- Mougin Vincent
- Mousavi Parsa
- Mrejen Matías
- Mubarik Sumaira
- Mueller Ulrich Otto
- Mulita Francesk
- Munjal Kavita
- Murillo-Zamora Efrén
- Murray Christopher J L
- Musallam Khaled M
- Musina Ana-Maria
- Mustafa Ghulam
- Myung Woojae
- Nafei Ayoub
- Nagarajan Ahamarshan Jayaraman
- Naghavi Pirouz
- Naik Ganesh R
- Naik Gurudatta
- Nainu Firzan
- Najdaghi Soroush
- Nakhostin Ansari Noureddin
- Nangia Vinay
- Narasimha Swamy Sreenivas
- Nargus Shumaila
- Narimani Davani Delaram
- Nascimento Bruno Ramos
- Nascimento Gustavo G
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- Wojewodzic Marcin W
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- Wolfe Charles D A
- Wu Chenkai
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- Wulf Hanson Sarah
- Xiao Hong
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- Yezli Saber
- Yigzaw Zeamanuel Anteneh
- Yiğit Arzu
- Yiğit Vahit
- Yin Dehui
- Yip Paul
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Yu Elaine A
- Yu Yong
- Yuan Chun-Wei
- Yusuf Hadiza
- Zafar Uzma
- Zafari Nima
- Zahid Mondal Hasan
- Zakham Fathiah
- Zaki Nazar
- Zerfu Taddese Alemu
- Zhang Haijun
- Zhang Jingya
- Zhang Liqun
- Zhang Yunquan
- Zhang Zhiqiang
- Zhao Xiu-Ju George
- Zhao Yang
- Zhao Zhongyi
- Zhong Chenwen
- Zhou Bolun
- Zhou Juexiao
- Zhou Shangcheng
- Zhu Bin
- Zhumagaliuly Abzal
- Zielińska Magdalena
- Zoghi Ghazal
- Zumla Alimuddin
- Zyoud Sa'ed H
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050. Methods: Using forecasts of major drivers of health such as the Socio-demographic Index (SDI; a composite measure of lag-distributed income per capita, mean years of education, and total fertility under 25 years of age) and the full set of risk factor exposures captured by GBD, we provide cause-specific forecasts of mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) by age and sex from 2022 to 2050 for 204 countries and territories, 21 GBD regions, seven super-regions, and the world. All analyses were done at the cause-specific level so that only risk factors deemed causal by the GBD comparative risk assessment influenced future trajectories of mortality for each disease. Cause-specific mortality was modelled using mixed-effects models with SDI and time as the main covariates, and the combined impact of causal risk factors as an offset in the model. At the all-cause mortality level, we captured unexplained variation by modelling residuals with an autoregressive integrated moving average model with drift attenuation. These all-cause forecasts constrained the cause-specific forecasts at successively deeper levels of the GBD cause hierarchy using cascading mortality models, thus ensuring a robust estimate of cause-specific mortality. For non-fatal measures (eg, low back pain), incidence and prevalence were forecasted from mixed-effects models with SDI as the main covariate, and YLDs were computed from the resulting prevalence forecasts and average disability weights from GBD. Alternative future scenarios were constructed by replacing appropriate reference trajectories for risk factors with hypothetical trajectories of gradual elimination of risk factor exposure from current levels to 2050. The scenarios were constructed from various sets of risk factors: environmental risks (Safer Environment scenario), risks associated with communicable, maternal, neonatal, and nutritional diseases (CMNNs; Improved Childhood Nutrition and Vaccination scenario), risks associated with major non-communicable diseases (NCDs; Improved Behavioural and Metabolic Risks scenario), and the combined effects of these three scenarios. Using the Shared Socioeconomic Pathways climate scenarios SSP2-4.5 as reference and SSP1-1.9 as an optimistic alternative in the Safer Environment scenario, we accounted for climate change impact on health by using the most recent Intergovernmental Panel on Climate Change temperature forecasts and published trajectories of ambient air pollution for the same two scenarios. Life expectancy and healthy life expectancy were computed using standard methods. The forecasting framework includes computing the age-sex-specific future population for each location and separately for each scenario. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. Findings: In the reference scenario forecast, global and super-regional life expectancy increased from 2022 to 2050, but improvement was at a slower pace than in the three decades preceding the COVID-19 pandemic (beginning in 2020). Gains in future life expectancy were forecasted to be greatest in super-regions with comparatively low life expectancies (such as sub-Saharan Africa) compared with super-regions with higher life expectancies (such as the high-income super-region), leading to a trend towards convergence in life expectancy across locations between now and 2050. At the super-region level, forecasted healthy life expectancy patterns were similar to those of life expectancies. Forecasts for the reference scenario found that health will improve in the coming decades, with all-cause age-standardised DALY rates decreasing in every GBD super-region. The total DALY burden measured in counts, however, will increase in every super-region, largely a function of population ageing and growth. We also forecasted that both DALY counts and age-standardised DALY rates will continue to shift from CMNNs to NCDs, with the most pronounced shifts occurring in sub-Saharan Africa (60·1% [95% UI 56·8–63·1] of DALYs were from CMNNs in 2022 compared with 35·8% [31·0–45·0] in 2050) and south Asia (31·7% [29·2–34·1] to 15·5% [13·7–17·5]). This shift is reflected in the leading global causes of DALYs, with the top four causes in 2050 being ischaemic heart disease, stroke, diabetes, and chronic obstructive pulmonary disease, compared with 2022, with ischaemic heart disease, neonatal disorders, stroke, and lower respiratory infections at the top. The global proportion of DALYs due to YLDs likewise increased from 33·8% (27·4–40·3) to 41·1% (33·9–48·1) from 2022 to 2050, demonstrating an important shift in overall disease burden towards morbidity and away from premature death. The largest shift of this kind was forecasted for sub-Saharan Africa, from 20·1% (15·6–25·3) of DALYs due to YLDs in 2022 to 35·6% (26·5–43·0) in 2050. In the assessment of alternative future scenarios, the combined effects of the scenarios (Safer Environment, Improved Childhood Nutrition and Vaccination, and Improved Behavioural and Metabolic Risks scenarios) demonstrated an important decrease in the global burden of DALYs in 2050 of 15·4% (13·5–17·5) compared with the reference scenario, with decreases across super-regions ranging from 10·4% (9·7–11·3) in the high-income super-region to 23·9% (20·7–27·3) in north Africa and the Middle East. The Safer Environment scenario had its largest decrease in sub-Saharan Africa (5·2% [3·5–6·8]), the Improved Behavioural and Metabolic Risks scenario in north Africa and the Middle East (23·2% [20·2–26·5]), and the Improved Nutrition and Vaccination scenario in sub-Saharan Africa (2·0% [–0·6 to 3·6]). Interpretation: Globally, life expectancy and age-standardised disease burden were forecasted to improve between 2022 and 2050, with the majority of the burden continuing to shift from CMNNs to NCDs. That said, continued progress on reducing the CMNN disease burden will be dependent on maintaining investment in and policy emphasis on CMNN disease prevention and treatment. Mostly due to growth and ageing of populations, the number of deaths and DALYs due to all causes combined will generally increase. By constructing alternative future scenarios wherein certain risk exposures are eliminated by 2050, we have shown that opportunities exist to substantially improve health outcomes in the future through concerted efforts to prevent exposure to well established risk factors and to expand access to key health interventions
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
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- null null
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- Yildirim Yasemin
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- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
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- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
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- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. Hallaråker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
- A. Jaremczuk-Kaczmarczyk
- A. Jarzebowski
- A. Jefferies
- A. Jekthammer
- A. Jerzewski
- A. John Camm
- A. John Camm
- A. John Camm
- A. Jones
- A. Kaczmarzyk-Radka
- A. Karczmarczyk
- A. Katta
- A. Kemmel
- A. Khan
- A. Khokhlov
- A. Koch
- A. Kolesnikova
- A. Kolodzinska
- A. Komlo
- A. Konopka
- A. Kopf
- A. Krueger
- A. Krzesiak-Lodyga
- A. Lavoie
- A. Lawande
- A. Lee
- A. Lettenström
- A. Leyva Rendón
- A. Lindberg
- A. Lindh
- A. Lindourkova
- A. Lischka-Lindner
- A. Lo Buglio
- A. Lopes
- A. Lopez
- A. Lucassen
- A. Ludkova
- A. Lysek-Jozefowicz
- A. Mannermyr
- A. Manzanal Rey
- A. Mariani
- A. Markiewicz
- A. Marquand
- A. Martin Vila
- A. Martinelli
- A. Maselli
- A. Matoltsy
- A. Mauric
- A. Meirino
- A. Menezes Lorga Filho
- A. Merliss
- A. Metzgier-Gumiela
- A. Mielot
- A. Mirtl
- A. Miyashita
- A. Mizuno
- A. Mowafy
- A. Murray
- A. Naguib
- A. Nagy
- A. Nakagomi
- A. Nakata
- A. Navarro
- A. Negrete Palma
- A. Negri
- A. Niemirycz-Makurat
- A. Nowak
- A. Nygaard
- A. Ohanissian
- A. Ohlsson
- A. Olofsson
- A. Ortiz
- A. Osberg
- A. Ota
- A. Oto
- A. Ovsannikova
- A. Page
- A. Papp
- A. Parkhomenko
- A. Pawelska-Buczen
- A. Pedersen
- A. Phrommintikul
- A. Pinter
- A. Pizzini
- A. Plauskat
- A. Podczeck-Schweighofer
- A. Postolache
- A. Pronk
- A. Pustelnik
- A. Quick
- A. Quietzsch
- A. Quisi
- A. Raczynska
- A. Raisaro
- A. Ramdass
- A. Reda
- A. Rodrigues
- A. Ross
- A. Sabir
- A. Sage
- A. Said
- A. Salinas
- A. Sapatyi
- A. Sasaki
- A. Scaccianoce
- A. Seoane Blanco
- A. Sidor
- A. Singal
- A. Skein
- A. Soliman
- A. Soma
- A. Sossich
- A. Spyropoulos
- A. Srinivas
- A. Sriwichian
- A. Stallinga-de Vos
- A. Steffens
- A. Suissa
- A. Sulc
- A. Svilaas
- A. Sword
- A. Szczepanska
- A. Szilagyi
- A. Szulowska
- A. Taguchi
- A. Talkenberger
- A. Tangsirira
- A. Tetlak
- A. Thatcher
- A. Therkelsen
- A. Thomson
- A. Tomasello
- A. Ushakov
- A. Vandorpe
- A. Vertes
- A. Vishnevsky
- A. Vonbank
- A. Wakeman
- A. Waldman
- A. Warke
- A. Wassef
- A. Wierzbicka
- A. Williams
- A. Wilson
- A. Wirdby
- A. Wutthimanop
- A. Yagensky
- A. Yoshimura
- A. Zateyshchikova
- A. Østrem
- A.-B. Ekstrand
- A.-K. Ascoop
- A.-M. Barbuto
- A.-M. Ohlin
- A.A. Damonte
- A.A. Fernandez
- A.B. Lensebraaten
- A.C. Billiaux
- A.C. Ingaramo
- A.C. Rothwell
- A.C. Tovar Castaneda
- A.C.P. Barretto
- A.D. Hrabar
- A.G. Ravi Shankar
- A.J. Kleiban
- A.J. McLeod
- A.L. Baek
- A.L. Cappi
- A.L. Tufare
- A.M. Jackson
- A.P. Drummond Wainstein
- A.P. Macagnan
- A.R. Kelsall
- A.R. Park
- A.S. Pandey
- Ajay K. Kakkar
- Ajay K. Kakkar
- Alex Parkhomenko
- Alex Spyropoulos
- Alexander G.G. Turpie
- Ali Oto
- Antonio Carlos Pereira Barretto
- B. Allasia
- B. Alzand
- B. Ayres
- B. Chatlaong
- B. Clarke
- B. Conway
- B. Coutu
- B. Crousillat
- B. Curyllo
- B. Deshpande
- B. Dolecka
- B. Doucet
- B. Dubois
- B. Dudzik-Richter
- B. Eriksson
- B. Fox
- B. Gaszner
- B. Ghezai
- B. Gosciniecka
- B. Hawkins
- B. Herrero Maeso
- B. Hoffmann
- B. Ikitimur
- B. Jacobson
- B. Jacobson
- B. Jansson
- B. Jimeno Besa
- B. Kurylo
- B. Kurylo
- B. Li
- B. Liu
- B. Lokesh
- B. Martinsson
- B. Mautner
- B. Merkely
- B. Mooso
- B. Naratreekoon
- B. Okopien
- B. Opielowska-Nowak
- B. Ostrowska-Pomian
- B. Racz
- B. Raghuraman
- B. Ramjattan
- B. Rzyczkowska
- B. Sarai
- B. Schaefer
- B. Schneeweiß
- B. Schweitzer
- B. Sievers
- B. Silaruks
- B. Singh
- B. Sinha
- B. Stephanie
- B. Strohmer
- B. Subbaraman
- B. Unterkircher
- B. Uppelschoten
- B. Vandrus
- B. Vanhauwaert
- B. Vishwanathan
- B. Vogel
- B. Voigts
- B. Ward
- B. Wollaert
- B. Wozakowska-Kaplon
- B. Zhou
- B.-T. Kellner
- B.A.J. Stockins Fernandez
- B.C. Jung
- B.E. Groenemeijer
- B.R. Park
- B.Y. Sayin
- Barry Jacobson
- Bernard J. Gersh
- C. A'Court
- C. Arabetti
- C. Astudillo
- C. Axthelm
- C. Batta
- C. Beltra
- C. Bergeron
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- Hiroshi Oda
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- Samuel Z. Goldhaber
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- Sang Hee Kim
- Sang Hyun Kim
- Sanjay Kakkar
- Seil Oh
- Sen Adachi
- Shinya Goto
- Sho Nagai
- Shu Suzuki
- Shunichi Nagai
- Shunji Suzuki
- Stuart J. Connolly
- Susumu Adachi
- Susumu Suzuki
- Sylvia Haas
- Sylvia Haas
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- Tadashi Nakamura
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- W.L. Liu
- W.M. Kutayli
- W.N. Guo
- W.S. Son
- W.T. Lim
- W.Y. Lee
- W.Y. Zheng
- Wael Al Mahmeed
- Werner Hacke
- X. Chen
- X. Giry
- X. Li
- X. Robiro Robiro
- X. Sheng
- X. Vandamme
- X. Viñolas
- X.A. He
- X.F. Huang
- X.J. Gao
- X.J. Shi
- X.L. Luo
- X.S. Cheng
- X.S. Hu
- X.W. Yan
- X.Y. Zhu
- Xavier Viñolas
- Y. Abe
- Y. Atsuchi
- Y. Balthazar
- Y. Belenkova
- Y. Campisto
- Y. Emura
- Y. Fujii
- Y. Fujisawa
- Y. Go
- Y. Gomez Perez
- Y. Gottwalles
- Y. Guo
- Y. Haraguchi
- Y. Hata
- Y. Hatori
- Y. Hayashi
- Y. Ivanova
- Y. Jiao
- Y. Kamogawa
- Y. Kato
- Y. Katsube
- Y. Katsuda
- Y. Kawada
- Y. Kelfkens
- Y. Kitami
- Y. Koretsune
- Y. Koshibu
- Y. Kumai
- Y. Maruyama
- Y. Matsuura
- Y. Mizuno
- Y. Moiseeva
- Y. Mostovoy
- Y. Niijima
- Y. Nishida
- Y. Nishihata
- Y. Oba
- Y. Onuki Pearce
- Y. Orlov
- Y. Osmolovskaya
- Y. Park
- Y. Saito
- Y. Sakamoto
- Y. Samejima
- Y. Santanakorn
- Y. Sasagawa
- Y. Sekine
- Y. Seta
- Y. Shapovalova
- Y. Shiina
- Y. Shimoyama
- Y. Shozawa
- Y. Stipp
- Y. Suzuki
- Y. Svyshchenko
- Y. Takagi
- Y. Tsuchiya
- Y. Ueyama
- Y. Vandekerckhove
- Y. Vorasettakarnkij
- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma
- Author
- A Morales
- A Schroeder
- A Subramanian
- Ami Yu
- B Efron
- B Zhang
- BM Bolstad
- Bu-Yeo Kim
- BY Kim
- BY Kim
- C Boccaccio
- CF Lee
- Chul Ju Han
- Dong Wook Choi
- E Bair
- E Cariani
- Eun-Ran Park
- H Yasrebi
- HG Woo
- Imhoi Koo
- J Liu
- J Wu
- Ja June Jang
- Jae Won Lee
- Je-Geun Lee
- JK Choi
- JM Llovet
- JS Lee
- K Murata
- Kee-Ho Lee
- Kyung-Suk Suh
- L Kuźbicki
- L Matthews
- M Kanehisa
- M Marí
- M Murohashi
- M Tsuchiya
- MB Eisen
- Myung-Haing Cho
- N Fehrenbacher
- PJ Heagerty
- QH Ye
- R Colombari
- S Jain
- S Roessler
- S Wang
- Sang Bum Kim
- Seon Rang Woo
- SM Kim
- Su-Hyeon Kim
- Suk-Jin Yang
- Sun-Hoo Park
- SY Lee
- SY Yoon
- T Sakaguchi
- TT Lah
- Won Kyung Jeon
- X Xu
- Y Hoshida
- Y Kurokawa
- YF Xu
- YH Yang
- YL Jia
- Young Il Yeom
- Young Nyun Park
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cracks, microcracks and fracture in polymer structures: Formation, detection, autonomic repair
- Author
- Abdullah
- Adams
- Aditya
- Akdemir
- Akhtar
- Albdiry
- Alicia
- Anderson
- Andrews
- Anton Nikiforov
- Aramaki
- Argon
- Argon
- Argon
- Aronhime
- Awaja
- Awaja
- Awaja
- Awaja
- Awaja
- Awaja
- Awaja
- Awaja
- Awaja
- Awaja
- Ayewah
- Azimi
- Azimi
- Aïssa
- Babot
- Badia
- Bafekrpour
- Bafekrpour
- Bao
- Bayraktar
- Beattie
- Bechel
- Becu
- Beier
- Belarbi
- Ben Daly
- Ben Daly
- Berfield
- Bergman
- Blaiszik
- Blaiszik
- Bleay
- Boesl
- Boonyapookana
- Bowles
- Boyd
- Brady
- Breen
- Brighenti
- Brown
- Brown
- Brown
- Brown
- Brown
- Brown
- Buckley
- Bucknall
- Bull
- Bull
- Bárány
- Cantwell
- Caridis
- Carpinteri
- Chandrasekaran
- Chang
- Chang
- Charca
- Charca
- Chasiotis
- Chen
- Chen
- Chen
- Chen
- Cheng
- Cho
- Cho
- Choi
- Choi
- Chu
- Chudnovsky
- Chughtai
- Ciobanu
- Cohen
- Colin
- Colin
- Colin
- Colin
- Collette
- Courtney
- Crick
- Dag
- Dai
- Davies
- Davies
- Davis
- Daǧli
- Decelle
- Dewapriya
- Dharan
- Dry
- Dry
- Duncan
- Dunkers
- El-Shekeil
- Elber
- Ellison
- Endo
- Eslami
- Faltinsen
- Feldman
- Fellers
- Fidan
- Firas Awaja
- Friedrich
- Gac
- Galvin
- Gammon
- Gao
- Gao
- Gardner
- Garnier
- Ghassemieh
- Gheorghiu
- Ghosh
- Giesa
- Gigliotti
- Griffith
- Gross
- Gu
- Guerjouma
- Halford
- Han
- Hancox
- Hargou
- Harris
- Harris
- Hayes
- Hayes
- Hayes
- Hayes
- Henkee
- Henneke
- Henry
- Hiemstra
- Higaki
- Hill
- Ho
- Hogg
- Hsieh
- Huang
- Huang
- Huguet
- Hui
- Hui
- Iskanderova
- Jana
- Jiang
- Johnsen
- Johnson
- Jones
- Jones
- Jordan
- Joseph
- Ju
- Jung
- Junyan
- Kalista
- Kalista
- kambour
- Kanchanomai
- Kaouache
- Kapadia
- Karger-Kocsis
- Kausch
- Kawagoe
- Kawaguchi
- Kessler
- Kessler
- Kessler
- Kim
- Kim
- Kim
- Kinloch
- Kinra
- Koyanagi
- Kramer
- Krishnan
- Kumar
- Kumosa
- Kumosa
- Kumosa
- Kumosa
- Kumosa
- Kurtz
- Kurtz
- Lach
- Lafarie-Frenot
- Lafarie-Frenot
- Lafarie-Frenot
- Lansinger
- Launey
- Lauterwasser
- Lawson
- Lee
- Lee
- Leman
- Lestari
- Li
- Lim
- Lin
- Liotier
- Liu
- Liu
- Liu
- Luo
- Luo
- Luo
- Ma
- Mackerle
- Madhukar
- Maiti
- Manjunatha
- Manoj Tripathi
- Manson
- Manson
- Maslov
- Mauzac
- McGeorge
- McMurray
- Megel
- Meure
- Mian
- Miceli
- Michler
- Michler
- Miller
- Mills
- Miwa
- Morgan
- Mouritz
- Mouritz
- Mouzakis
- Nagy
- Nairn
- Narin
- Nathani
- Nicola Pugno
- Niemann
- Nikishkov
- Nizamuddin
- Noble
- Novozhilov
- Olivier
- Olivier
- Outwater
- Owen
- O’Brien
- Pang
- Pang
- Pant
- Papanicolaou
- Parnasov
- Pegoretti
- Phua
- Pingkarawat
- Plaisted
- Plumbridge
- Plumbridge
- Plumridge
- Pochiraju
- Polk
- Poowadin
- Pugno
- Pugno
- Pugno
- Pugno
- Purslow
- Rabinowitz
- Radon
- Ratcliffe
- Ray
- Ray
- Regel
- Reis
- Reis
- Rice
- Rice
- Rice
- Rink
- Rizzo
- Robert
- Rouquie
- Rovere
- Roy
- Roylance
- Rule
- Sabu
- Saint-Michel
- Salazar
- Samuel
- Sato
- Sauer
- Sauer
- Sautereau
- Sawpan
- Schapery
- Schilling
- Schmidt
- Schmidt
- Scholey
- Schultz
- Seale
- Seltzer
- Serabian
- Sha
- Sha
- Shang
- Shang
- Shang
- Sharma
- Shengnan Zhang
- Shimokawa
- Shtein
- Sket
- Sket
- Slater
- Song
- Soundararajah
- Stifter
- Stifter
- Stock
- Subramaniyan
- Sue
- Summerscales
- Summerscales
- Sun
- Sun
- Sutherland
- Syrett
- Takeda
- Takeda
- Takeno
- Takeno
- Talbott
- Talreja
- Tan
- Tandon
- Tark Han
- Taylor
- Tim
- Timmerman
- Timmerman
- Timmerman
- Trask
- Trask
- Tsotsis
- Tzou
- Usamentiaga
- van Melick
- Varley
- Varley
- Varley
- Varna
- Vikrant
- Visco
- Vu
- Vu
- Wang
- Wang
- Wang
- Wetzel
- White
- Wiesauer
- Williams
- Wisnom
- Woo
- Woo
- Wöhler
- Xiang
- Ye
- Yi
- Yuan
- Yuan
- Zako
- Zhang
- Zhang
- Zhu
- Zhu
- Ziadeh
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
The first author would like to acknowledge the financial support from the European Union under the FP7 COFUND Marie Curie Action. N.M.P. is supported by the European Research Council (ERC StG Ideas 2011 n. 279985 BIHSNAM, ERC PoC 2015 n. 693670 SILKENE), and by the EU under the FET Graphene Flagship (WP 14 “Polymer nano-composites” n. 696656)
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
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- Anne-Lise Børresen-Dale
- Annegien Broeks
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- Antonio Pea
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- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
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- Qinying Xu
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- Sandrine Boyault
- Sandro Morganella
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- Sanja Mijalkovic
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- Sara Sadeghi
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- Satoru Miyano
- Satoshi Hirano
- Savitri Krishnamurthy
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- Vincenzo Corbo
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- W Kimryn Rathmell
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- Wan Choi
- Wanding Zhou
- Wang Liang-Bo
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- Wei Jiao
- Wendl Michael C
- Wenyi Wang
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- Wheeler David A
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- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
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