4 research outputs found
Cultural orientation of self-bias in perceptual matching
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 28/06/2019
- Field of study
This work was supported by grants from the Economic and Social Research Council (ES/K013424/1), the National Natural Science Foundation of China (31371017), and the Research Grants Council of Hong Kong (HKU758412H)Peer reviewedPublisher PD
Vorapaxar in the secondary prevention of atherothrombotic events
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- T. Abell
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- T. Zinger
- T.A. Carlson
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- U. Baldini
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- V. Sardin
- V. Schaefer
- V. Schotte
- V. Silva
- V. Singh
- V. Stan
- V. Stedham
- V. Thijs
- V. Toyota
- V.H. Hansen
- V.L. Laet
- V.L. Nicely
- V.V. Bonarjee
- V.V. Nilsen
- W. Arnold
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- W. Ferrada
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- W. He
- W. Holt
- W. Horne
- W. Johnson
- W. Leimbach
- W. Palasik
- W. Penny
- W. Pluta
- W. Rogers
- W. Sobiczewski
- W. Staszkiewicz
- W. Stueflotten
- W. Sturm
- W. Szybka
- W. Van Landegem
- W. Zwinnen
- W.B. Campbell
- W.D. Doty
- W.G. Carlini
- W.P. Klinke
- W.P. McGuinn
- W.R. Ardito
- W.R. Cashion
- W.W. Wilson
- X. Garcia-Moll
- X. Liu
- Y. Aladro Benito
- Y. Chandrashekhar
- Y. Cottin
- Y. Feldman
- Y. Hirano
- Y. Hiraoka
- Y. Honda
- Y. Lampl
- Y. Manabe
- Y. Niinuma
- Y. Okada
- Y. Oono
- Y. Pesant
- Y. Rozenman
- Y. Samson
- Y. Shinohara
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- Y.K. Chan
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- Z. Bednarkiewicz
- Z. Chmielak
- Z. Gasior
- Z. Kalita
- Z. Klimsa
- Z. Kornacewicz-Jach
- Z. Lorenc
- Z. Mohamed
- Z. Monhart
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2012
- Field of study
Item does not contain fulltextBACKGROUND: Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1. METHODS: We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive vorapaxar (2.5 mg daily) or matching placebo and followed them for a median of 30 months. The primary efficacy end point was the composite of death from cardiovascular causes, myocardial infarction, or stroke. After 2 years, the data and safety monitoring board recommended discontinuation of the study treatment in patients with a history of stroke owing to the risk of intracranial hemorrhage. RESULTS: At 3 years, the primary end point had occurred in 1028 patients (9.3%) in the vorapaxar group and in 1176 patients (10.5%) in the placebo group (hazard ratio for the vorapaxar group, 0.87; 95% confidence interval [CI], 0.80 to 0.94; P<0.001). Cardiovascular death, myocardial infarction, stroke, or recurrent ischemia leading to revascularization occurred in 1259 patients (11.2%) in the vorapaxar group and 1417 patients (12.4%) in the placebo group (hazard ratio, 0.88; 95% CI, 0.82 to 0.95; P=0.001). Moderate or severe bleeding occurred in 4.2% of patients who received vorapaxar and 2.5% of those who received placebo (hazard ratio, 1.66; 95% CI, 1.43 to 1.93; P<0.001). There was an increase in the rate of intracranial hemorrhage in the vorapaxar group (1.0%, vs. 0.5% in the placebo group; P<0.001). CONCLUSIONS: Inhibition of PAR-1 with vorapaxar reduced the risk of cardiovascular death or ischemic events in patients with stable atherosclerosis who were receiving standard therapy. However, it increased the risk of moderate or severe bleeding, including intracranial hemorrhage. (Funded by Merck; TRA 2P-TIMI 50 ClinicalTrials.gov number, NCT00526474.)
Chemical Composition of Icy Satellite Surfaces
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- Stack John F
- Stanley J.C.
- State of the County Los Angeles 1987. Los Angeles
- Stavig G.R.
- Stein M.L.
- Steinberg Laurence
- Steiner Dale R
- Steingasser Jean
- Stephens Michael
- Stern Bernard W
- Stewart Frank
- Stolarik M.
- Stone John
- Stoneburner Bryan C
- Street Richard Steven
- Strom Robert
- Sue David
- Sue David
- Suh Hyuk-Kyo
- Suinn Richard M
- Surovell Hariette
- Sutherland Debbie Ann
- Suzuki Peter T
- Swartout Robert R
- Swenson I.
- Taitte W. Lawson
- Takaki Ronald
- Tan Thomas
- Tanaka Ronald
- Taylor
- Taylor Charles A
- TheMaster Plan Renewed
- Thom Wah Chan
- Thompson M.
- Thompson R.
- Thompson Vivian L
- Tien-Hyatt J.L.
- Tienda Marta
- Tokeshi Jimmy
- Tomasi Lydio F
- Tonai Rosalyn
- Torres-Gil Fernando
- Trachtenberg J.A.
- Tran Thanh Van
- Tran Thanh Van
- Trask Haunani-Kay
- Trotter Edgar P
- Trotter Rhonda
- Trotter Rhonda
- Tsuchida Nobuya
- Tsukamoto Mary
- Tsushima W.T.
- Tuck Donald
- Tune Suelyn Ching
- Ty-Casper Linda
- U.S. Census Bureau
- U.S. Equal Employment Opportunity Commission
- US. Commission on Civil Rights.
- Uyematsu Amy
- Valeri Valerio
- Vallangca Caridad Concepcion
- Van Tran Thanh
- Vasquez Jesse M
- Vellela
- Villapando Venny
- Viray Manuel A
- Viviano Frank
- Vost Lynn A
- Wada Yori
- Waianae Coast Culture and Arts Society
- Waldinger Roger D
- Walls Thomas K
- Wang Wayne
- Warren William H
- Washington
- Washington Michael
- Wax Rosalie H
- Weeks Charles J. Jr.
- Weisbender
- Weiss Julian M
- Wendt Albert
- Werner Emmy E
- Westermeyer Joseph
- Whang Minsun Sung
- White C.
- White Virginia
- Whitehead John S
- Wiley Richard
- Wilkinson Doris
- Williams C.L.
- Williams R.A. Jr.
- Wilson William H
- Wolf Charlotte
- Wolf Susan
- Wolfram Walt
- Woll Allen L
- Won-Doornink Myong Jin
- Wong H.K.
- Wong Jerry
- Wong Marshall J
- Wong Shawn
- Wong Shelley Diane
- Wong-Chu Jim
- WongHo Leung
- Worthley
- Wright Doris J
- Wright Ian
- Yamane Tokio
- Yao E.L.
- Yao E.L.
- Yao Esther Lee
- Yee Barbara W
- Yeung Alexander
- Yoneda Karl Goso
- Yoo Suisun
- Young Rosalie F
- Yu Diane C
- Yu Eui-Young
- Yu Eui-Young
- Yuan D.Y.
- Yuen Shirley Mark
- Zanger Virginia Vogel
- Zbaracki Jacqueline Ulmen
- Zeng Zifan
- Zinsmeister Karl
- Zinsmeister Karl
- Zulfacar Diane
- Publication venue
- 'UCLA American Indian Studies Center'
- Publication date
- Field of study