Near-infrared probe as a quality control tool for milk powder blending processes

This study aims to evaluate the suitability and reliability of Process Analytical Tools (PAT) in monitoring milk powder blending processes. The uniformity end point was predicted using a Near-Infrared (NIR) probe, and subsequently validated using offline Fourier Transform Infrared Spectroscopy (FTIR). A standard milk formulation (SMF) made up of 50% lactose, 40% skim milk powder, and 10% whey protein concentrate was used. Additionally, the detection limit of the NIR probe was investigated using vitamin C powder. The average predicted uniformity end point using the inline NIR fixed reference (63.89 ± 2.06 min), and dynamic reference conformity test (63.00 ± 5.25 min) were comparable with the offline FTIR measurement (56.6 ± 0.71 min). A three-component Partial Least Square Regression (PLSR) model was constructed and validated for vitamin C. The detection limit is 0.11%, which is higher than the vitamin C level commonly found in most infant milk formula (0.035%)

Persistent hiccup in a continuous ambulatory peritoneal dialysis patient following ingestion of star fruit

AbstractAnimal studies have suggested that ingestion of star fruit, which belongs to the Oxalidaceae family, may cause neurotoxicity. Outbreaks of intractable hiccups have been reported following ingestion of star fruit in patients on regular hemodialysis. Other complaints have included insomnia, agitation and mental confusion. We report a patient on continuous ambulatory peritoneal dialysis (CAPD) who presented with acute confusion and persistent hiccup following ingestion of star fruit. Symptoms resolved spontaneously. Other reported cases and management strategies are discussed

Modelling and analysis of asymmetrical latency in packet-based networks for current differential protection application

Current differential protection typically requires symmetrical communications channels—with equal latency in each direction—for correct operation. Conventionally, this has been delivered using protocols such as IEEE C37.94 over a Time-Division Multiplexing (TDM) wide-area network (WAN). Modern packet-based WANs offer improvements in efficiency, flexibility, and cost-effectiveness for utility applications. However, jitter is unavoidable in packet-based networks and, in extreme cases, jitter inevitably results in substantial asymmetrical latency in communications paths. This paper clearly defines how a new source of asymmetry arises due to the use of "de-jitter" buffers, which can jeopardize critical protection services. This is demonstrated using an analytical modelling approach, which precisely quantifies the degree of risk, and through real-time demonstration with actual devices, involving current differential protection over an IP/MPLS WAN. Using a novel method of real-time manipulation of Ethernet traffic to emulate large WANs, the modelling approach has been validated. It is shown how the sensitivity of relays to asymmetry depends on the protection settings and the magnitude of the measured load current. To address the risk of protection maloperation, a new approach for compensating for asymmetrical latency has been comprehensively validated. These developments will be of immediate interest to utilities operating, or migrating to, a packet-based infrastructure

The analysis of alphaâ 1â antitrypsin glycosylation with direct LCâ MS/MS

A liquid chromatographyâ tandem mass spectrometry (LCâ MS/MS)â based methodology has been developed to differentiate coreâ and antennaryâ fucosylated glycosylation of glycopeptides. Both the glycosylation sites (heterogeneity) and multiple possible glycan occupancy at each site (microheterogeneity) can be resolved via intact glycopeptide analysis. The serum glycoprotein alphaâ 1â antitrypsin (A1AT) which contains both coreâ and antennaryâ fucosylated glycosites was used in this study. Sialidase was used to remove the sialic acids in order to simplify the glycosylation microheterogeneity and to enhance the MS signal of glycopeptides with similar glycan structures. β1â 3,4 galactosidase was used to differentiate coreâ and antennaryâ fucosylation. Inâ source dissociation was found to severely affect the identification and quantification of glycopeptides with low abundance glycan modification. The settings of the mass spectrometer were therefore optimized to minimize the inâ source dissociation. A threeâ step mass spectrometry fragmentation strategy was used for glycopeptide identification, facilitated by pGlyco software annotation and manual checking. The collision energy used for initial glycopeptide fragmentation was found to be crucial for improved detection of oxonium ions and better selection of Y1 ion (peptide+GlcNAc). Structural assignments revealed that all three glycosylation sites of A1AT glycopeptides contain complex Nâ glycan structures: site Asn70 contains biantennary glycans without fucosylation; site Asn107 contains biâ , triâ and tetraâ antennary glycans with both coreâ and antennaryâ fucosylation; site Asn271 contains biâ and triâ antennary glycans with both coreâ and antennaryâ fucosylation. The relative intensity of coreâ and antennaryâ fucosylation on Asn107 was similar to that of the A1AT protein indicating that the glycosylation level of Asn107 is much larger than the other two sites.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146302/1/elps6432_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146302/2/elps6432.pd

Cross-disciplinary collaboration through WuZhiQiao Project to foster cultural exchange and community engagement

In 2013, students of the Technological and Higher Education Institute of Hong Kong (THEi), with the support of WuZhiQiao (WZQ) Charitable Foundation, formed a core team of 11 students to organize and participate in social service projects to help the underprivileged in the Chinese mainland. WuZhiQiao (WZQ) projects, the first cross-region social service engagement by THEi students, bring together students from Hong Kong and the Mainland. WZQ Charitable Foundation aims to help the Chinese traditional village in building Pedestrian Bridge and organizing community projects. Since there are Chinese villages facing flooding during rainy seasons, the local villagers will be trapped inside the village without the chance to go outside or wade outside the village. There are hundreds of such villages and they highly need our help. Each project mainly involves two or three institutes from Hong Kong and the Mainland, and they organize the whole volunteer project including planning, investigation, design, promotion and operation. Through involvement in different states or provinces, WZQ projects provide good chance of communication and interaction between Hong Kong teams and the Mainland teams and advocate intercultural social services. The projects can foster the cultural exchange between Hong Kong and the Mainland. Moreover, the majority of WZQ project members are coming from the fields of engineering, architecture and health care. We can practice our learning from lectures through the project implementation. Different parties are involved in the engineering projects including clients, consultants, contractors, surveyors, engineers and workers. Engineering students can gain good understanding of the holistic picture of a real-life engineering project. We visited the location village for investigation to learn more about the local culture, geometry and the people’s needs and discussed with the Mainland Team through online chatting tools in order to propose the optimal pedestrian building design and other community projects. Having spent over six months in planning and preparation, THEi students will implement a bridge-building and community project in Chongqing in January 2015. Through engagement in this service-learning project, not only the undergraduates of THEi can benefit through personal development but the life quality of the disadvantaged can also be improved

Do Low Preoperative Vitamin D Levels Reduce the Accuracy of Quick Parathyroid Hormone in Predicting Postthyroidectomy Hypocalcemia?

BACKGROUND: Although some studies have suggested that low preoperative 25-hydroxyvitamin D (25-OHD) levels may increase the risk of hypocalcemia and decrease the accuracy of single quick parathyroid hormone in predicting hypocalcemia after total thyroidectomy, the literature remains scarce and inconsistent. Our study aimed to address these issues. METHODS: Of the 281 consecutive patients who underwent a total/completion total thyroidectomy, 244 (86.8 %) did not require any oral calcium and/or calcitriol supplements (group 1), while 37 (13.2 %) did (group 2) at hospital discharge. 25-OHD level was checked 1 day before surgery, and postoperative quick parathyroid hormone (PTH) was checked at skin closure (PTH-SC). Postoperative serum calcium was checked regularly. Hypocalcemia was defined by the presence of symptoms or adjusted calcium of <1.90 mmol/L. Significant factors for hypocalcemia were determined by univariate and multivariate analyses. The accuracy of PTH-SC in predicting hypocalcemia was measured by area under a receiver operating characteristic curve (AUC), and the AUC of PTH-SC was compared between patients with preoperative 25-OHD <15 and ≥15 ng/mL via bootstrapping. RESULTS: Preoperative 25-OHD level was not significantly different between groups 1 and 2 (13.1 vs. 12.5 ng/mL, p = 0.175). After adjusting for other significant factors, PTH-SC (odds ratio 2.49, 95 % confidence interval 1.52–4.07, p < 0.001) and parathyroid autotransplantation (odds ratio 3.23, 95 % confidence interval 1.22–8.60, p = 0.019) were the two independent factors for hypocalcemia. The AUC of PTH-SC was similar between those with 25-OHD <15 and ≥15 ng/mL (0.880 vs. 0.850, p = 0.61) CONCLUSIONS: Low 25-OHD was not a significant factor for hypocalcemia and did not lower the accuracy of quick PTH in predicting postthyroidectomy hypocalcemia

Optimization and clinical validation of a pathogen detection microarray

New design and optimization of pathogen detection microarrays is shown to allow robust and accurate detection of a range of pathogens. The customized microarray platform includes a method for reducing PCR bias during DNA amplification

PLASER: Pronunciation Learning via Automatic Speech Recognition

PLASER is a multimedia tool with instant feedback designed to teach English pronunciation for high-school students of Hong Kong whose mother tongue is Cantonese Chinese. The objective is to teach correct pronunciation and not to assess a student&apos;s overall pronunciation quality. Major challenges related to speech recognition technology include: allowance for non-native accent, reliable and corrective feedbacks, and visualization of errors

An empirical investigation on Google Classroom: use behaviour of Malaysian school teachers

Google Classroom (GC) has become a prominent online learning platform in Malaysia since the government’s official announcement and later sees its boost in usage again during the COVID-19 pandemic due to the implementation of emergency remote teaching. The literature has unveiled that the mean score pertaining to technological knowledge in the context of GC usage was the lowest. Therefore, this study aims to investigate the level of GC use and the significant influence of facilitating conditions, habit, and behavioural intention on GC use behaviour among Malaysian teachers. A total of 37 secondary school teachers participated in an online quantitative survey consisting of 22 five-point Likert scale items. Descriptive statistics and standard regression analysis were used to analyse the data. Findings found that the extent of agreement and utilisation of GC during the pandemic were only moderate, requiring increased focus as a precautionary measure for potential future scenarios, such as another pandemic, where remote learning becomes the sole viable option. Results also suggested habit (β = 1.128, p < .0005) as the most significant factor that influences Malaysian teachers’ GC use behaviour. Thus, future initiatives in boosting the intentions of using GC among Malaysian teachers need to be considered

Projecting the 10-year costs of care and mortality burden of depression until 2032: a Markov modelling study developed from real-world data

Background Based on real-world data, we developed a 10-year prediction model to estimate the burden among patients with depression from the public healthcare system payer's perspective to inform early resource planning in Hong Kong. Methods We developed a Markov cohort model with yearly cycles specifically capturing the pathway of treatment-resistant depression (TRD) and comorbidity development along the disease course. Projected from 2023 to 2032, primary outcomes included costs of all-cause and psychiatric care, and secondary outcomes were all-cause deaths, years of life lived, and quality-adjusted life-years. Using the territory-wide electronic medical records, we identified 25,190 patients aged ≥10 years with newly diagnosed depression from 2014 to 2016 with follow-up until 2020 to observe the real-world time-to-event pattern, based on which costs and time-varying transition inputs were derived using negative binomial modelling and parametric survival analysis. We applied the model as both closed cohort, which studied a fixed cohort of incident patients in 2023, and open cohort, which introduced incident patients by year from 2014 to 2032. Utilities and annual new patients were from published sources. Findings With 9217 new patients in 2023, our closed cohort model projected the 10-year cumulative costs of all-cause and psychiatric care to reach US$309.0 million and US$58.3 million, respectively, with 899 deaths (case fatality rate: 9.8%) by 2032. In our open cohort model, 55,849–57,896 active prevalent cases would cost more than US$322.3 million and US$60.7 million, respectively, with more than 943 deaths annually from 2023 to 2032. Fewer than 20% of cases would live with TRD or comorbidities but contribute 31–54% of the costs. The greatest collective burden would occur in women aged above 40, but men aged above 65 and below 25 with medical history would have the highest costs per patient-year. The key cost drivers were relevant to the early disease stages. Interpretation A limited proportion of patients would develop TRD and comorbidities but contribute to a high proportion of costs, which necessitates appropriate attention and resource allocation. Our projection also demonstrates the application of real-world data to model long-term costs and mortality, which aid policymakers anticipate foreseeable burden and undertake budget planning to prepare for the care need in alternative scenarios