Instrumentation for a Mars Entry Experiment

This paper is based on a preliminary design of an entry science package for a Voyager Mars entry and landing capsule. The introduction outlines the various conditions under which the instruments must operate and the range of anticipated measurement parameters. The following sections describe the technology survey, alternative measurement concepts considered, and the instruments selected for the entry science package. The last section is devoted to the complete subsystem operation, sequence of events, data handling, and the system of backup measurements

Long-term strategies for flood risk management: scenario definition and strategic alternative design

This report reviews some mainstream existing methods of scenario development and use, as well as experiences with the design and assessment of strategic alternatives for flood risk management. Next, a procedure and methods are proposed and discussed. Thirdly, the procedure and methods are tried on the Schelde Estuary and the Thames Estuary and, finally, conclusions are draw

Beneficial Inner-City Quay Walls?

Inner-city quay walls in public urban areas: expense or added value? These civil structures approach, reach or exceed the end of their life span. This threatens the quality of the public urban area. Many municipalities are still willing to invest in the management of inner-city quay walls, despite the costs. Apparently, the quay walls generate more benefits than that are initially expected based on their original functions. Until now, municipalities have failed to determine the added value of inner-city quay walls. Theoretical and practical research suggests that adequate asset management is indispensable. Nevertheless, no research focuses on valuable management of inner-city quays, in terms of performance, costs, benefits and risks. How to decide on a management strategy that adds the most value to the public area? A new framework should identify and incorporate the value of inner-city quay walls in the management process

Effecten van uiterwaardverlaging op landbouw en natuur langs de Maas

De overkoepelde studie Integrale Verkenning Maas (IVM) is een verkennend onderzoek naar de mogelijkheden om een verhoogde afvoer van de Maas van 4.600 m3/s door het beheersgebied van de Directie Limburg te voeren. Randvoorwaarden daarbij is, dat de waterstanden behorende bij de huidige veiligheidsnorm (zoals vastgelegd in de rivierenwet) op de bedijkte Maas en de daaraan gerelateerde standen op de onbedijkte Maas niet worden overschreden. Daarnaast dienen de te nemen maatregelen bij te dragen aan een verbetering van de ruimtelijke kwaliteit langs de Maas. IVM leidt tot een advies dat is opgebouwd uit een samenhangende benadering vanuit de invalshoeken Rivierkunde, Natuur, Economie&Maatschappij en ruimte&Landschap. Deze IVM-deelstudie inzichtelijk wat de effecten zijn van rivierverruimende maatregelen op de natuur- en landbouwfunctie langs de verschillende Maastrajecten. De inzichten die onderliggende studie heeft opgeleverd zijn in het IVM Achtergronddocument Natuur (IVM-N-03, Lieveld et al. (2003)) gebruikt om: -Sturing te kunnen geven aan het samenstellen van de maatregelenpakketten in de strategieën (welk niveau van uiterwaardverlaging kies je in welk traject); -De beoordeling van de maatregelenpakketten voor natuur te kunnen kwantificeren (welke (oppervlaktes van) ecotopen ontstaan bij een bepaald niveau van uiterwaardverlaging in een bepaald traject)

Paving the Way for a Real-Time Context-Aware Predictive Architecture

Internet of Things society generates and needs to consume huge amounts of data in a demanding context-aware scenario. Such exponentially growing data sources require the use of novel processing methodologies, technologies and tools to facilitate data processing in order to detect and prevent situations of interest for the users in their particular context. To solve this issue, we propose an architecture which making use of emerging technologies and cloud platforms can process huge amounts of heterogeneous data and promptly alert users of relevant situations for a particular domain according to their context. Last, but not least, we will provide a graphical tool for domain experts to easily model, automatically generate code and deploy the situations to be detected and the actions to be taken in consequence. The proposal will be evaluated through a real case study related to air quality monitoring and lung diseases in collaboration with a doctor specialist on lung diseases of a public hospital

Intraoperative radiotherapy during awake craniotomies: preliminary results of a single-center case series

Awake craniotomies are performed to avoid postoperative neurological deficits when resecting lesions in the eloquent cortex, especially the speech area. Intraoperative radiotherapy (IORT) has recently focused on optimizing the oncological treatment of primary malignant brain tumors and metastases. Herein, for the first time, we present preliminary results of IORT in the setting of awake craniotomies. From 2021 to 2022, all patients undergoing awake craniotomies for tumor resection combined with IORT were analyzed retrospectively. Demographical and clinical data, operative procedure, and treatment-related complications were evaluated. Five patients were identified (age (mean ± standard deviation (SD): 65 ± 13.5 years (y)). A solid left frontal metastasis was detected in the first patient (female, 49 y). The second patient (male, 72 y) presented with a solid metastasis on the left parietal lobe. The third patient (male, 52 y) was diagnosed with a left temporoparietal metastasis. Patient four (male, 74 y) was diagnosed with a high-grade glioma on the left frontal lobe. A metastasis on the left temporooccipital lobe was detected in the fifth patient (male, 78 y). After awake craniotomy and macroscopic complete tumor resection, intraoperative tumor bed irradiation was carried out with 50 kV x-rays and a total of 20 Gy for 16.7 ± 2.5 min. During a mean follow-up of 6.3 ± 2.6 months, none of the patients developed any surgery- or IORT-related complications or disabling permanent neurological deficits. Intraoperative radiotherapy in combination with awake craniotomy seems to be feasible and safe

The Ursinus Weekly, December 2, 1976

Ursinus news in brief: Field hockey places second; Take \u27em to court?; McCarthy addresses Pre-Legal group; Forum Committee finalizes program • Alumni Directory published • Board plans tuition increase; Welcomes two new members • Career night planned • RPR addresses faculty • CR\u27s make a difference • Letters to the editor: More on Fritz ; A backside view of Wismer cafeteria • Comment: A tale of two students • Musical notes • Forum reviews: Tapestry, Mostovoys • Two gentlemen at Ursinus • Movie review: Network • Union board meets • Philly Co. • Bears 0-9 ... but the future looks brighter • Ursinus Equestrian Club news • Swim season opens • Phils not shoppinghttps://digitalcommons.ursinus.edu/weekly/1063/thumbnail.jp

Small poly-L-lysines improve cationic lipid-mediated gene transfer in vascular cells in vitro and in vivo

The potential of two small poly-L-lysines ( sPLLs), low molecular weight sPLL ( LMW-L) containing 7 - 30 lysine residues and L18 with 18 lysine repeats, to enhance the efficiency of liposome-mediated gene transfer ( GT) with cationic lipid DOCSPER {[}1,3- dioleoyloxy- 2-( N-5-carbamoyl-spermine)-propane] in vascular smooth muscle cells ( SMCs) was investigated. Dynamic light scattering was used for determination of particle size. Confocal microscopy was applied for colocalization studies of sPLLs and plasmid DNA inside cells. GT was performed in proliferating and quiescent primary porcine SMCs in vitro and in vivo in porcine femoral arteries. At low ionic strength, sPLLs formed small complexes with DNA ( 50 100 nm). At high ionic strength, large complexes ( 11 mu m) were observed without any significant differences in particle size between lipoplexes ( DOCSPER/ DNA) and lipopolyplexes ( DOCSPER/ sPLL/ DNA). Both sPLLs were colocalized with DNA inside cells 24 h after transfection, protecting DNA against degradation. DOCSPER/ sPLL/ DNA formulations enhanced GT in vitro up to 5- fold, in a porcine model using local periadventitial application up to 1.5- fold. Both sPLLs significantly increased liposome- mediated GT. Poly-L-lysine L18 was superior to LMW-L since it enabled maximal GT at a 10-fold lower concentration. Thus, sPLLs may serve as enhancers for GT applications in SMCs in vitro and in vivo using local delivery. Copyright (c) 2007 S. Karger AG, Basel

Information and Communication Technologies— Opportunities to Mobilize Agricultural Science for Development

Knowledge, information, and data—and the social and physical infrastructures that carry them—are widely recognized as key building blocks for more sustainable agriculture, effective agricultural science, and productive partnerships among the global research community. Through investments in e-Science infrastructure and collaboration on one hand, and rapid developments in digital devices and connectivity in rural areas, the ways that scientists, academics, and development workers create, share, and apply agricultural knowledge is being transformed through the use of information and communication technologies (ICTs). This paper examines some trends and opportunities associated with the use of these ICTs in agriculturalscience for development